Invasive Fungal Infections Flashcards
(26 cards)
Endemic Mycoses
Histoplasmosis
Blastomycosis
Coccidiodomycosis
Opportunistic Mycoses
Candidasis
Cryptococcosis
Aspergillosis
RF for Fungal Infections
Organ or bone marrow transplant
Cytotoxic chemotherapy
Indwelling catheter, burns, trauma
Broad Spectrum Abx
Candida is acquired from?
GI tract
Catheter
Immunosuppressed RF for invasive candidiasis
Neutropenia Lymphoreticular or Hematologic malignancies Uncontrolled Diabetes Corticosteroids Agents
Other RF for invasive candidiasis
CV catheter Total Parenteral nutrition (TPN) Extensive surgery Burns Renal failure, dialysis Abx Prior infection
Candida Lab Testing
Culture
Germ tube (within 1-2h)
PNA or FISH
Serologic
Echinocandin Drugs
Capsofungin
Micafungin
Anidala IV
Resistant bugs?
Krusei Glabrata (overcome with high dose)
Other bugs
Tropicalis
Parapsilosis
Fluconazole dose
6 mg for C. albicans, C. tropicalis, C. parapsilosis,
12 mg for C. glabrata
Itra and Vori have activity against?
C. glabrata and C. krusei
Echinocandins have activity against
C. glabrata and C. krusei
NOT parapsilosis
Amp B has activity againsts
Candida
Aspergillosis Pathogenic species
Fumigatus
Flavus
Niger
Aspergillosis infection via?
Inhalation + impaired host defenses
RF for aspergillosis?
Prolonged neutropenia
Steroids
Cytotoxic agents
Abx
RF for Cryptococcus
HIV infection
Lymphoproliferative disorders
Sarcoidosis
Steroids
Histoplasmosis Endemic to
Ohio and Mississippi River Valley
Blastomycosis endemic to?
Ohio and Mississippi River Valley
Great Lakes
Chronic Pulmonary Blastomycosis
Weight loss
Night sweats
Thought to have TB
Coccidiodomycosis endemic to?
California to Texas
RF for Severe, disseminated coccidiodomycosis
Filipino Prego Immunecompromised Male Neonate AB or B blood type
Chronic Persistent Pneumonia
Greater than 6 weeks of primary disease
Coughing up blood
Pulmonary scarring
