Investigation & management of the mature lame animal Flashcards

(130 cards)

1
Q

General considerations in approaching the mature lame small animal - signalment

A

Elbow dysplasia
- labs, rotties, Bernese mountain dogs, Newfies

HIF
- spaniels

Infraspinatus contracture
- spaniels

Lateral patella luxation
- flat coat retrievers

Medial patella luxation
- many small breeds including Frenchies & occasionally labs and English bull terrier

Lumbosacral dz
- GSD

Neoplasia
- large and giant breeds

Cellulitis
- outdoor, unneutered male cat

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2
Q

General considerations in approaching the mature lame small animal - History clues (acute lameness, chronic lameness, intermittent, acute on chronic)

A

Acute lameness
- sprains
- acute cruciate rupture
- fractures both pathological and traumatic
- cellulitis

Chronic lameness
- OA
- humeral intracondylar fissure
- nerve root tumour

Intermittent
- patella luxation
- dislocation of the tendon of origin of the long digital extensor
- superficial digital flexor instability

Acute on chronic
- cruciate rupture
- pathological fracture
- condylar fissure subsequent to HIF

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3
Q

General considerations in approaching the mature lame small animal - clinical exam

A
  • reduced or increased ROM and swelling to joints
  • instability to joints or associated sesamoids e.g. patella
  • pain and crepitus on manipulation of joints
  • pain or crepitus on palpation of the long bones and joints or soft tissues
  • muscle atrophy
  • neuro deficits
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4
Q

General considerations in approaching the mature lame small animal - further investigations

A

Radiography
- mainstay of investigations of the lame small animal

CT
- esp of the elbow and shoulder

MRI
- spine, nerve roots, stifles and shoulder

Joint taps
- detection of septic arthritis and polyarthritides

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5
Q

Cruciate disease - prevalence & signalment

A
  • extremely common dz
  • not exaggerated to say any dog with hindlimb lameness has cruciate dz until proven otherwise
  • is occasionally seen in the overweight cat or as part of a more severe stifle disruption
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6
Q

Patella subluxation - prevalence & signalment

A
  • common condition
  • less frequently seen in the cat (traumatic but also developmental in Abyssinian and Devon Rex)
  • often asymptomatic
  • common in small breeds e.g. Yorkies, poodles, frenchies, CKCS
  • also seen in English bulldogs and labs
  • lateral patella subluxation reported in the flat coated retriever (much less common than medial patella subluxation)
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7
Q

Shoulder soft tissue conditions - what happens and why?

A

The shoulder is innately unstable and relies on soft tissues for stability
- muscles: supra-, infra and subscapularis and teres minor
- tendons: biceps tendon of origin
- ligaments: medial and lateral glenohumeral

As a result of this it is prone to sprains, particularly the medial glenohumeral ligament and other soft tissue injuries.

The biceps tendon can become inflamed or rupture -> bicipital tendonitis.

A specific condition seen in working dogs is infraspinatus contracture.

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8
Q

Shoulder soft tissue conditions - diagnosis

A

Shoulder palpation
- any pain elicited?

Biceps tendon test
- apply pressure to the bicipital groove whilst retracting the shoulder and extending the elbow
- is there any pain elicited by this?
- is it possible to extend the elbow greater on 1 side?
– this is indicative of either biceps tendon rupture of avulsion (tearing of the tendon from its bony origin)

Manipulation under GA
- some debate as to how useful this test is
- the degree of abduction and adduction can be measured but is a little subjective
- greater adduction -> potential lateral glenohumeral ligament issue
- greater abduction -> potential medial glenohumeral ligament issue

Radiography
- mineralisation of the infra and supraspinatus tendons
- rely on CE for the significance of these findings

US
- particularly useful to examine the biceps tendon
- high frequency linear or hockey stick transducer is the appropriate probe

CT & MRI
- both can be useful
- CT requires contrast enhancement cf the elbow

Arthroscopy
- gold standard
- allows management as well as diagnosis

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9
Q

Shoulder soft tissue conditions - tx

A
  • rest and NSAIDs are often beneficial but the time taken for any sprain to the collateral ligaments can be long
  • the medial collateral is often the sprained ligament and it can be imbricated with sutures or lightly cauterised to induce scarring and stability, but neither tx appears effective
  • tenosynovitis of the bicipital tendon can be treated with intra-articular corticosteroids or sectioning of the tendon which appears to make little difference in the dogs ability to walk
    – this can be left or the tendon attached to the proximal humerus with a spiked washer and screw (tenodesis)
  • removal of mineralised parts of the tendons of insertion of the supra and infraspinatus muscles can occasionally improve any lameness but these are often incidental findings and therefor the significance of changes can be difficult to assess
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10
Q

Infraspinatus contracture - signalment & signs

A
  • relatively rare condition
  • seen primarily in working breeds e.g. springer spaniel
  • a progressive condition
  • characteristic limb position
    – limb abducted, limp wrist posture
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11
Q

Infraspinatus contracture - tx & prognosis

A
  • sectioning the tendon close to its insertion on the humerus
  • can recur but generally prognosis is good
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12
Q

Humeral intracondylar fissure (FIC) - old name

A
  • incomplete ossification of the humeral condyle (IOHC)
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13
Q

Humeral intracondylar fissure (FIC) - signalment

A
  • spaniels including the Brittany, springer and CKCS
  • common in the Frenchie but a recent study shows that when this condition is seen in the young dog they will go on to fuse when an adult
  • young to middle aged dogs with no sex predilection
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14
Q

Humeral intracondylar fissure (FIC) - CS

A
  • chronic forelimb lameness or acute if associated with lateral, medial or bicondylar fracture
  • muscle atrophy and elbow swelling
  • pain on manipulation of elbow and when pressure applied across condyle
  • acute lameness associated with condylar fracture more often seen in the young puppy
    – very common in Frenchie with minimal trauma e.g. jumping from sofa or O’s arms
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15
Q

Humeral intracondylar fissure (FIC) - diagnosis

A

Radiography
- multiple views required to be at right angles to the fissure in order to demonstrate the lesion
- sclerosis and thickening of the lateral supracondylar crest may also be seen

CT
- modality of choice
- may be a fissure or initially an area of sclerosis within the condyle
- contrary to initial assessment of these cases, this condition may not be a failure of the capitulum and trochlea of the condyle to fuse but 1 which can develop in the mature animal
- some recent studies suggest that it may be another manifestation of elbow incongruity resulting in the anconeus engaging on the caudal intercondylar region resulting in a stress fracture

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16
Q

Humeral intracondylar fissure (FIC) - tx

A

Conservative management
- rest and NSAIDS
- always a risk of condylar fracture which significant morbidity

Surgical management
1. placement of large transcondylar screw (4.5mm in most spaniels and labs)
- prone to significant number of complications
- breakage of the screw as the fissure rarely heals
- inadvertent penetration of the joint
- these can be minimised by placing the screw from medial to lateral (more difficult) and placing the screw as a lagged implant rather than positional (but the compression of the fracture site can lead to joint incongruence)
- CT produced templates can be used to aid screw placement
2. due to the suggestion that this condition can result from elbow incongruity a proximal ulna osteotomy has been used to bring about the healing of the HIF
- this technique has proven successful although it is not without its own complications although they’re less than those associated with a trans condylar screw

These fissures probably never heal hence the need for the strongest implant i.e. screw with the greatest core diameter

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17
Q

Carpal injuries - general considerations

A
  • variable presentations but usually associated with varying degrees of lameness, instability and soft tissue swelling
  • pain is not a consistent finding particularly in the chronic cases
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18
Q

Carpal injuries: hyperextension injuries - most common injury, signs, other causes

A
  • most common carpal injury is that of hyperextension
  • dog or cat jumps over a wall with a large drop the other side
  • palmar ligaments and palmar cartilage are damaged irrevocably
  • carpus is swollen with varying degrees of palmagrade stance (i.e. flat on their feet)
  • can also occur as a result of destructive arthritis
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19
Q

Carpal injuries - diagnosis

A

Radiographs determine the level of the injury (stressed views helpful)
- antebrachiocarpal
- intercarpal
- carpometacarpal
This may not matter as generally a pan carpal arthrodesis is used to tx this condition

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20
Q

Carpal injuries - tx

A
  • partial or pancarpal arthrodesis i.e. joint fusion as the ligaments will neither heal nor be capable of repair
  • partial arthrodesis is rarely performed as it results in strain on adjacent joints
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21
Q

Carpal conditions: incomplete ossification of the radiocarpal bone - signalment & tx

A
  • boxers and springer spaniels
  • attempts to heal often fail as this is a similar pathology to HIF
  • treat with pancarpal arthrodesis as healing of the bone very unlikely
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22
Q

Carpal conditions: stenosing tenosynovitis of the abductor polices longus - signalment & signs

A
  • chronic lameness seen in exuberant dogs
  • pain on carpal flexion
  • soft tissue swelling medial carpus
  • boney exostoses seen over the medial aspect of the radius in chronic cases
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23
Q

Carpal conditions: stenosing tenosynovitis of the abductor polices longus - diagnosis & tx

A
  • US will demonstrate changes to tendon and increased fluid in the tendon sheath
  • tx with steroid injection into the sheath, freeing the tendon or sectioning tendon (tenotomy) although the latter has been associated with marked degeneration of the carpus and is not recommended
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24
Q

Tarsal conditions: plantar ligament degeneration - signalment & signs

A
  • collies, particularly Shetland sheepdogs
  • insidious onset
  • proximal inter tarsal subluxation with bilateral changes
  • denigration progresses to rupture and plantigrade stance
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25
Tarsal conditions: plantar ligament degeneration - diagnosis & tx
- clinical and radiographic diagnosis with proximal intertarsal subluxation - treat with laterally applied plate and arthrodesis of the calcaneoquartal joint - no further immobilisation required other than a support bandage for a week
26
Tarsal injuries in the racing greyhound
- rarely race again - predominantly a right limb injury as in the UK these dogs race anti-clockwise and most force is generated by the RH - combination of subluxations and fractures - medial aspect of the joint collapses with fracture to central bone (several types with its own classification system) - fractures and subluxations occur of the calcaneus and calcaneoquartal joint - specialist injury requiring referrals
27
Tarsal conditions: gastrocnemius tendinopathy - signalment & signs
- older labs and Dobermans - chronic hindlimb lameness - often bilateral - relatively common - painful swelling to achilles tendon and mineralization on radiographs - characteristic clawing of foot due to lengthening of gastroc but not the SDFT tendon
28
Tarsal conditions: gastrocnemius tendinopathy - tx
- resect tendon and place calcaneal tibial screw or transarticular external fixator to support the repair or a pantarsal arthrodesis
29
Open traumatic carpal and tarsal injuries - how do they occur and what to do?
- arise from trauma particularly and RTAs - accompanied by varying degrees of soft tissue damage and contamination - manage the soft tissue injuries 1st - temporary external fixator may help in the initial stabilisation of the joint - many of these injuries will require arthrodesis to manage - other than the talocrural and antebrachiocarpal joints all others are low motion joints - loss of low motion joints results in minimal loss of function
30
Hindlimb conditions: gracilis contracture - signalment, signs & tx
- mature GSD - characteristic gait: short stride with a rapid, elastic medial rotation of the paw, internal rotation of the hock, and external rotation of the calcaneus - progressive with no effective tx although some success reported with adipose tissue stem cells and laser tx
31
Hindlimb conditions: iliopsoas myopathy - signs, diagnosis & tx
- progressive hindlimb lameness - variable severity but can be severe - pain on extension and rotation of hip - diagnosis with MRI or US - rest and NSAIDs or section the muscle at its insertion on the lesser trochanter
32
Hindlimb conditions: long digital extensor avulsion - signalment, signs & tx
- young large breed dogs with minimal trauma - joint effusion with small bone fragment - chronic cases show mineralisation of the torn tendon and a deficit in the femur - tx is by reattaching the fragment or tendonesis to the proximal tibia
33
Hindlimb conditions: long digital extensor tendon luxation - cause & tx
- associated with TPLO surgery - tx by tendonesis or securing the ligamentar attachments of the tendon
34
Hindlimb conditions: avulsion of the gastrocnemius - signs & tx
- either the medial or lateral gastrocnemius - low grade trauma resulting in weight bearing lameness and slightly plantigrade stance - fabellae are displaced - tx is by reattaching the gastrocnemius by direct suturing, screw and spiked washer or suture the gastroc bodies to femur through bone tunnels or suture anchors
35
Hindlimb conditions: superficial flexor luxation - signalment, signs, tx
- usually lateral - an uncommon condition - most commonly seen in the Shetland sheepdog - intermittent lameness with an audible popping sound and sensation - swelling over the tip of the calcaneus Tx - either suturing the torn retinaculum but recurrence is not uncommon - screwing the SDF to the calcaneus
36
Neoplasia - types, where they are found, signalment
- can be primary (i.e. originating from the bone) or secondary (i.e. originating from a tumour elsewhere which has mets to bone) - the most common primary tumour is the osteosarcoma accounting for up to 80% of bone tumours - the osteosarcoma has predilection sites: proximal humerus and distal radius and proximal tibia and distal femur -- these tumours fail to cross the joint -- they will have mets to the lungs by time of diagnosis - other tumours types include fibrosarcoma, chondrosarcoma, histolytic tumour and the synovial cell tumour - giant and large breeds with av age of 5-8y are predisposed - the cat suffers from similar tumour types but these are generally less aggressive and less malignant - histolytic sarcoma: arises from the joint
37
Neoplasia - CS
- slow onset of lameness - disuse muscle atrophy - insidious and poorly responsive to analgesia - moderate to marked pain on palpation of the tumour site - may be accompanied by marked muscle atrophy - moderate to marked soft tissue swelling - there may be an acute deterioration when the weakened bone fracture -> pathological fracture - the pathological fracture often occurs with minimal trauma - always consider this when an older dog has fractured a limb with no or little history of trauma
38
Neoplasia - diagnosis
- CS & hx highly suggestive - radiography: may show both a proliferative and destructive pattern, 'sunburst' appearance - remember the joint is usually spared with an osteosarcoma cf arthritis or a synovial cell tumour or histiocytic sarcoma which is centred on the joint - the initial changes of the osteosarcoma occur on the endosteal surface - always do chest rads (3 views are advised - L & R laterals and DV) - CT is more sensitive way to look for chest mets
39
Neoplasia - histological diagnosis
- often diagnosis can be made on CS and radiographic signs alone - if the diagnosis is unclear or we need to determine whether a lesion is a primary or secondary neoplasm or the O is considered surgical or medical management then it is important to know the precise nature of the tumour - this is achieved with core biopsies obtained with a Jamshidi needle - radiography confirms correct placement of the needle - biopsies should be taken from the centre of the lesion (the periphery may contain reactive bone only) - if considering management recommend CT of chest Jamshidi needles - also designed for bone marrow aspiration - the stylet is removed when entering the bone to harvest a core - vigorous twisting and rocking breaks the core from the bone - the stylet is used to push the core from the free end of the needle and the core is placed in formal saline - several biopsies are taken to increase the diagnostic yield
40
Neoplasia - tx
- it's important that the O is aware that it's unlikely, in the case of most bone tumours, that the tx will be curative - limb amputation offers immediate pain relief - amputation is better tolerated in the hindlimb and in smaller dogs - limb sparing procedures are available with placement of an auto or allograft having excised the tumour - limb amputation can also be followed by the placement of an endoprosthesis - all surgical tx can be followed up by chemo e.g. carboplatin - some O will opt for medical management which is primarily analgesia - bisphosphates are esp useful in this situation (osteoclast inhibitors) - pts also good option
41
Neoplasia - prognosis
- prognosis for appendicular osteosarcoma in the dog is generally poor with lung mets being the usual outcome and cause of death - average survival times without tx would be less than 1 month - with limb amputation alone the median survival time is 4-5m - with amputation or limb sparing techniques followed by neoadjuvant chemo survival times of 9-10m have been reported - the same tumour in the cat carries a more favourable prognosis. if there is no evidence of mets then no follow up chemo is advised and median survival times range from 24-44m - the prognosis for other tumour types is variable
42
Neoplasia - nerve root tumours - where do they come from? where can they occur?
- nerve root tumours arise from the connective tissue around the nerve, a neurofibroma or sarcoma or the Schwann cells, a schwannoma - they can occur in the brachial and lumbosacral plexuses - on occasions the tumour can extend directly into the spinal cord or mets there
43
Neoplasia - nerve root tumours - prevalence & signalment
- they're rare tumours of the older dog ~8y/o - rarer in the cat
44
Neoplasia - nerve root tumours - signs
- chronic and insidious in their nature - painful - marked muscle atrophy usually in 1 limb (a monoparesis) as there is neurogenic as well as disuse atrophy - lameness generally unresponsive to analgesia
45
Neoplasia - nerve root tumours - diagnosis
- careful palpation of the axilla and rectal exam may detect their presence - MRI is the imaging modality of choice but rads with contrast (myelography) and CT can also be used
46
Neoplasia - nerve root tumours - tx
- surgical resection but this can be difficult and limb amp is often employed to remove the tumour -- additionally, limb function post-removal is poor - significant neurological deficits can result from the surgery if the limb is spared - the tumour may extend into the spinal canal making full excision, even with a laminectomy, difficult - recurrence is common following incomplete surgical excision - adjuvant chemo can be employed or radiotherapy - prognosis is guarded and recurrence within 1y is likely - is a local dz and rarely spread to other sites
47
Cruciate rupture in the cat - signalment, clinical findings, tx
- usually obese - minimal trauma - mineralisation of intra-articular findings may be insignficiant - extra-articular stabilisation but generally improve with rest only -> fibrosis of the joint allows stabilisation and usually function will return in a few months - TTA and TPLO have been performed
48
Patella fracture and dental anomaly syndrome (PADS) - what is it? signalment? signs
- patella fractures in cats - associated with retained deciduous teeth and a variety of other typical fractures - familial tendency occurring in young cats often with little or no hx of trauma - they're unable to fix the stifle (looks like a femoral neuropathy) - associated with fractures in other bones e.g. humerus, tibia and ischium. these occur later in the cats life (~8y) -> warn O that young cat with this is likely to have other fractures in the future - beware of bilateral dz
49
Patella fracture and dental anomaly syndrome (PADS) - tx options
These rarely heal Limited distraction - conservative management Marked distraction 1. circumferential wire 2. tension band without pin 3. pin and tension band 4. circumferential wire and pin and tension band Augmented with circumpatellar suture of wire or monofilament nylon to the tibial crest Often repair of the soft tissue structures is all you need to do to remain function. Most of these fractures result in functional outcome irrespective of the tx
50
Capital physis separation in the cat - what is it? signalment?
Fracture/separation of the femoral head physis: Salter Harris type I - usually animals are 6-7m/o - epiphysis remains in acetabulum attached by the trees ligament - often minimally displaced - so always take a 'frog-leg' view on rads - Burmese & British Blues
51
Capital physis separation in the cat - tx
- stabilisation with 2-3 K-wires or a lag screw, care to avoid penetration of the articular cartilage - 'apple-coring' (irregular loss of the bone of the femoral neck) common 3-6w post-op due to revascularisation of the femoral neck and subsequent bone remodelling, not usually a clinical problem - premature physeal closure and development of OA is common - poor healing reported in the Burmese which might result in a salvage procedure e.g. FHNE or total hip replacement
52
Joint dz in the dog and cat - Hx
- chronic lameness - worse in the morning or after rising particularly if been exercising - possible association with colder weather? - swelling to joints - reluctant to mount stairs/jump into cars - previous tick exposure or foreign travel? The cat shows less obvious signs but these include - reluctance to jump onto work surfaces - failure to groom - stiffness on rising - reduced activity levels
53
Joint dz in the dog and cat - CS
- walking stiffly - lameness in 1 or several limbs - joints swollen either as a result of effusion or periarticular fibrosis - pain on manipulation - reduced RoM - muscle atrophy - any systemic signs e.g. pyrexia, general malaise (could indicate polyarthritis)
54
Joint dz in the dog and cat - diagnosis
- CE - manipulation under GA - radiography/CT - joint taps/arthrocentesis - arthroscopy/arthrotomy - US of periarticular structures - CT - MRI Always compare to opposite limb
55
Joint dz in the dog and cat - diagnosis with arthrocentesis
- underused - aseptic prep of site - can be examined in house - if suspect sepsis send for culture in blood culture medium - always interpret in light of clinical findings
56
Joint dz in the dog and cat - diagnosis with arthroscopy
- morbidity low - magnification allows for identification of subtle pathologies - allows therapeutic intervention as well as diagnostic - steep learning curve - increased expense to O but in may joint dz it is considered gold standard e.g. elbow dysplasia
57
Joint dz in the dog and cat - diagnosis with arthrotomy
- more invasive and hence increased morbidity but allows direct visualisation - readily available and with limited approaches, e.g. medial arthrotomy to examine menisci, the damage to the synovial structures can be minimised - some procedures are difficult to do athroscopically e.g. meniscus removal - can obtain a synovial biopsy - when 1st performing arthroscopy always be prepped to convert to an open athrotomy
58
Osteoarthritis - pathophysiology
Primary arthritis - rare - hereditary predisposition and no underlying cause is identified Secondary arthritis - very common - developmental conditions e.g. elbow & hip dysplasia, osteochondrosis, patella luxation - degenerative conditions e.g. cruciate dz - inflammatory arthropathies e.g. rheumatoid arthritis, systemic lupus etc - trauma - sepsis - crystal induced (gout), very uncommon in dog and cat Pathophysiology - weight bearing areas of the joint undergo fibrillation (fraying) of the articular cartilage - this results in exposure of the subchondral bone to synovial fluid which then scleroses and produces osteophytes and resulting joint remodelling - all these processes are mediated by an array of synovial, chondrocytic and osteocytic messengers - the resulting synovitis and exposure of subchondral bone results in pain and reduced movement in the joint - the inflammatory process also produces a thickening of the joint capsule which reduces the RoM seen in the joint - investigations for OA are as for all other arthritides, the important feature is determining an underlying cause in secondary arthritis
59
Osteoarthritis - tx & management options
Analgesia - NSAIDs - opiates - NDMA antagonist - paracetamol - monoclonal antibodes Corticosteroids Disease modifying osteoarthritic drugs (DMOAD) - pentosan polysulphate (Catrophen) - platelet rich plasma - IRAP (Orthokine) - stem cell therapy - hyaluronic acid and polyacrylamide gel Nutraceuticals Environmental modifications Exercise & weight loss Photobiomodulation- laser therapy Extracorporeal shockwave tx TENS Therapeutic US Electromagnetic field therapy Acupuncture Hydro & physiotherapy
60
Osteoarthritis - tx & management with NSAIDs - how they work
- excellent anti-inflammatories and analgesics but are prone to causing GI ulceration and are usually given with food - act on 2 receptors: COX1 & COX2 - COX2 mediate inflammation - COX1 regulate blood flow to the kidneys and gastric mucosa - those which preferentially block COX2 are the latest additions to the group and are less likely to cause GI ulcerations (there is no evidence that antacids protect the stomach from this action) - these drugs should be used with caution in animals under GA: the regulation of renal blood flow is deleteriously affected, particularly in the hypotensive animal, resulting in renal damage and acute failure. only COX2 preferential drugs are licensed for preoperative use
61
Osteoarthritis - tx & management with NSAIDs - examples
Carprofen - many commercial preparations - selective COX2 inhibitor - licensed for long term use in the dog only Meloxicam - many commercial preparations - tablet and liquid forms - licensed for long term use in the dog and cat and some small animals Cimicoxib - (Cimalgex) - selective COX2 - licensed for long term use in the dog - not licensed in the cat Firocoxib - (Previcox) - selective COX2 - licensed for long term use in the dog - not licensed in the cat Grapipant - (Galliprant) - a piprant, an EP4 receptor antagonist blocking PGE2 (not a COX inhibitor) - licensed for long term use in the dog - not licensed in the cat Ketoprofen - (Ketofen) - not COX2 selective - is licensed for 30d use in the dog - licensed for 5d use in the cat Mavacoxib - (Trocoxil) - selective COX2 inhibitor - licensed for long term use in the dog - not licensed in the cat - is given once, then a single dose 2w later, then monthly Phenylbutazone - non selective compound - licensed for use in the cat but can be used long term in the dog although generally has been superseded by other NSAIDs Robenacoxib - (Onsior) - selective COX2 inhibitor - licensed for long term use in dogs and cats Tolfenamic acid - (Tolfedine) - unknown whether COX2 selective - can be used long term in the dog only if given for 4d with 3d rest Prednisolon and cinchophen - (Prednoleucotropin PLT) - combination of a steroid and non-steriodal - for use in the dog only but is not longer licensed in the UK
62
Osteoarthritis - tx & management with opiates
- can be used for severe acute flare ups of arthritis - controlled nature means use is limited Tramadol - oral opiate - efficacy and appropriate dosage of this compound has not been determined Buprenorphine - can be administered sublingually and systemic levels have been shown to be similar cf IM injections in the cat
63
Osteoarthritis - tx & management with NDMA antagonist
Amantadine - similar in action to ketamine - used primarily in the dog when NSAIDs are failing to provide adequate analgesia - modifies the spinal cord so it becomes less sensitive to the neurones acting on it / firing to it
64
Osteoarthritis - tx & management with paracetamol
- useful adjunct to NSAIDs - used only in the dogs - severe and often fatal toxic reaction in cats
65
Osteoarthritis - tx & management with monoclonal antibodies
- most recent addition to analgesic used to manage OA - nerve growth factor plays a role in the inflammatory process and also increases the sensitivity of the nociceptive neurons Librela - Bednivetmab - dogs - monoclonal antibody directed against nerve growth factor - injection given once monthly - effective and easier for client to manage - each injection is expensive but not necessarily when comparing with long term NSAIDs - few side effects as the antibody is degraded like other proteins by natural processes Solensia - Frunevetmab - cats - monoclonal antibody directed against nerve growth factor - injection given once monthly - effective and easier for client to manage - each injection is expensive but not necessarily when comparing with long term NSAIDs - few side effects as the antibody is degraded like other proteins by natural processes
66
Osteoarthritis - tx & management with corticosteroids
Examples - prednisolone - methylprednisolone - triamcinolone - dexamethasone - betamethasone Potent anti-inflammatories with resulting analgesia blocking the inflammatory pathway by action on the cell nucleus and reduced synthesis of COX2 among many other actions Can be given systemically, intra-articularly or extra-durably (lumbosarcal dz) Used in the shoulder particularly but should not be given on multiple occasions as this predisposes to cartilage degeneration and soft tissue mineralisation Systemic side effects result from both system and articular use
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Osteoarthritis - tx & management with Pentosan polysulphate
= Cartophen - a polysulphonates polysaccharide - single injection given weekly over a 4w period - should not be combined with NSAIDs - has potent anti-inflammatory activity but is not analgesic - stimulates mesenchymal stem cells to repair cartilage damage - reduces the inflammatory changes that damage the articular cartilage - improves blood flow to the affected joints - improves the quality and quantity of the synovial fluid - but evidence for its use is not great
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Osteoarthritis - tx & management with PRP & IRAP
- can be prepared in the lab or using kits in the practice - injected intra-articularly - contains many growth factors which are thought to stimulate mesenchymal stem cells and have anti-inflammatory activity - can be used for other soft tissue injuries such as ligament strains as well as in the management of OA - because it is autologous there are few side effects - true efficacy is still in some doubt - said to improve synovial thickness and reduce cartilage fibrillation IRAP (Orthokine) - an autologous conditioned plasma containing increased amounts of cytokines including interleukin 1 receptor antagonist
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Osteoarthritis - tx & management with stem cell therapy
- most common cell used is adipose tissue derived stem cell - the adipose tissue is harvested (usually from the inguinal region) and stem cells extracted and numbers increased at an external lab, this can take up to 3w - stem cells are then injected into the affected joints - this process may be combined with the use of PRP - it is thought that the mesenchymal stem cells can differentiate into chondrocytes and bring about healing in damaged cartilage - side effects are few due to the autologous nature of the material
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Hyaluronic acid and polyacrylamide gel
Hyaluronic acid - makes up a large component of the synovial fluid - it is strongly hydrophilic and produces a gel like material with water - can be injected into the joint and also given orally Polyacrylamide polygel - non-absorbable material that adheres to the synovial membrane joint capsule - causes the synovial membrane to thicken and become more cellular which offers a protective function to the joint - the synovial fluid increases in volume - beneficial effects are thought to last up to a year
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Osteoarthritis - tx & management with nutraceuticals
E.g. glucosamine, chondroitin, green lipped mussel, omega 3 fatty acids, turmeric (curcuminoids), collagen, avocado/soybean unsaponifiables, Elk velvet antler, SAMe, vitamin E - market leader is YuMove - there are also diets with increased levels of these compounds such as Hills jd (Mobility) - some evidence for the efficacy of omega 3 fatty acids - evidence of the beneficial effects of other compounds is scant although green lipped mussel and elk velvet antler have shown some promise
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Osteoarthritis - tx & management with exercise & environmental modifications
- introduce standard and consistent exercise on level surfaces, cheap and can be highly effective - environmental modifications such as ramps and non-slip surfaces in the house, and limit use of stairs - larger baskets for dogs and cats to sleep in - manage underlying pathologies - weight reduction in the overweight pt is possibly the single most important management process with an evidence base - the use of weight reducing diets is usually essential
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Osteoarthritis - tx & management with Photobiomodulation-laser therapy-cold infra-red light (K laser)
- type IV is the most recent type using several different light frequencies - evidence for effectiveness is scant but thought to have an anti-inflammatory action and mild analgesic effects and many O report an improvement
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Osteoarthritis - tx & management with extracorporeal shockwave tx
- high pressure non-linear high velocity sound waves - shown to have a beneficial effects
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Osteoarthritis - tx & management with TENS
= transcutaneous electrical nerve stimulation - no clinical trials have been conducted to look into its efficacy
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Osteoarthritis - tx & management with therapeutic US
- low and high frequency US - some trials have shown an improvement but these were very limited
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Osteoarthritis - tx & management with Electromagnetic field therapy
- application of either low, high or pulsed magnetic field - some evidence to suggest this is helpful
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Osteoarthritis - tx & management with acupuncture
- dry needle and electro-acupuncture and implantation where gold wire or beads are placed in the meridians - it is difficult to conduct studies which demonstrate the effectiveness or otherwise of this tx modality
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Osteoarthritis - tx & management with hydro & physiotherapy
- enlist the help of an ACPAT (association of chartered physiotherapist in animal therapy) qualified physiotherapist - much of the benefits have been extrapolated from man - cats are not good candidates for this tx - the use of non-weight bearing therapies such as swimming and particularly the use of a water treadmill can be very useful - the latter improves muscle mass and the weight bearing can be titrated by the depth of the water in the treadmill - there are various exercises and aids which the physiotherapist uses to improve muscle mass and proprioception which helps the dog manage their disease
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Osteoarthritis - tx & management with failure of medical management
Salvage procedures may be required - joint resurfacing -> Arthrex CUE (canine unicompartmental elbow) system, OAT and SOR systems - arthrodesis - arthroplasty - joint replacements (total or partial) - euthanasia
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Common ligament injuries
Plantar and palmar to hock and carpus Collaterals - shoulder particular medial glenohumeral - stifle, associated with luxation - elbow, associated with luxation Cruciates - cranial - very occasionally caudal
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Ligament injuries - pathology
- ligaments can only tolerate 10% elongation before permanent damage - inflammation of a ligament = desmitis
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Ligament injuries - investigations & diagnosis
- palpation (under GA) - assessment of joint stability (eg. after relocating elbow) - US for some ligaments but more useful for tendons such as patella, biceps and gastrocnemius - CT less useful but can see dystrophic mineralisation to supra- and infraspinatus tendons - MRI shoulder and stifle - Arthroscopy: shoulder and stifle
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Ligament injury classification - 1st degree
- few collagen fibres broken - swelling - rest, NSAIDs and cold compresses although there is debate in humans whether ice is beneficial
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Ligament injury classification - 2nd degree
- marked damage to fibres - haematoma - loss of some function - support dressing, NSAIDs, cold compress in acute phase, imbrication? rest for 3-6m - slow to heal imbrication = tightening of the ligament either with cautery or suture, supposed to help stability
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Ligament injury classification - 3rd degree
- complete rupture or avulsion from insertion/origin - primary repair if possible - support repair: prosthesis or transarticular fixator - arthrodesis for carpal and tarsal hyperextension and resulting subluxation
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Joint luxations - incongruent definition
- joint surface are abnormal in shape and do not articular perfectly
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Joint luxations - dysplasia definition
- abnormal joint development
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Joint luxations - subluxation definition
- joint surfaces displaced but maintain some contact
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Joint luxations - luxation definition
- no contact maintained between joint surfaces, luxation described by the position of the distal articular joint surfaces
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Joint luxations - 3 different aetiologies & their prevalence
Traumatic - common Congenital - rare Acquired/development - frequent - e.g. hip dysplasia
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Congenital luxations - signalment & aetiology
- rare - toy breeds: shoulder - staffies: elbow - the constituents bones and articular surfaces are abnormal in shape - this results in abnormal tensions on the joint and articulation
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Congenital elbow luxation
- 2 types reported - many of these animals show surprisingly little lameness which may be more mechanical rather than originating from pain - prognosis is fair
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Congenital elbow luxation - management
Conservative - analgesia, weight restriction, physiotherapy Surgical management - difficult due to abnormally shaped articular surfaces - success improved by early intervention - salvage procedures such as arthrodesis, arthroplasty and amputation may be required
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Developmental subluxations/incongruencies
- elbow dysplasia - hip dysplasia - often bilateral - develop secondary arthritis
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Traumatic luxations - aetiologies and general considerations
- considerable force required e.g. RTA or being hung from fence - associated with 3rd degree sprains i.e. complete rupture of the restraining ligaments - a traumatic arthritis is an almost inevitable consequence of this injury - surgery is required to manage these luxations (either closed or open reduction) - reduction is the relocation of the joint - closed reduction when no surgery is performed - open when a surgical approach is made and the joint reduced directly
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Acquired traumatic luxations - locations and cause
Hip - most common - craniodorsal commonest direction Talocrural - associated with malleolar fractures or collateral ligament rupture - common in RTA shear injuries Elbow - rare - associated with major trauma Carpus - subluxation following a fall
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Acquired traumatic luxations - diagnosis
Palpation often requiring GA Radiography - orthogonal views essential - can miss luxations if a single view is taken, esp of the elbow - stressed views may be required to determine site and severity of subluxation - examine for any articular bone fragments which make reduction impossible or unstable
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Acquired traumatic luxations - coxo-femoral joint (hip) - cause
- usually traumatic - developmental
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Acquired traumatic luxations - coxo-femoral joint (hip) - what are the hip stabilisers?
- teres ligament - joint capsule - dorsal acetabular rim - surface tension of joint fluid
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Acquired traumatic luxations - coxo-femoral joint (hip) - treatment
Closed reduction - more successful in the dog that the cat - for craniodorsal luxations place towel or rope around limb into groin - pull the limb in a ventrocaudal direction - lift hip over the acetabulum - always take lateral post-op radiograph to confirm reduction - Ehmers sling post-op? Open reduction - rectus femoris or iliofemoral suture - suture placed through tunnel in base of greater trochanter and either origin of rectus femurs muscle, or hole made in ventral aspect of ileum - suture tightened with hip slightly internally rotated - may cause slight internal rotation of paw- resolves when suture fails several weeks later Open reduction - trans-articular pin - more suitable for cats and small dogs - pin size and position important - reasonable function but limited adduction when in place - if hip reduction is incongruent the articular surface can be damaged - 2nd procedure is required to remove the implant (3w) - muscle contraction and peri-articular fibrosis hopefully keep the hip in place post pin removal Open reduction - toggle pin - maintains correct alignment and movement - joint is immediately stable - infection risk due to use of braided material - can be difficult to place particularly in well muscled dogs - 10-15% recurrence rate reported - ideal method
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Acquired traumatic luxation - elbow - cause
- often occurs after suspension from fence
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Acquired traumatic luxation - elbow - characteristic posture
- elbow outwardly rotated and abducted - a medial luxation - can often palpate the lower part of the trochlear of the humerus on the elbow
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Acquired traumatic luxation - elbow - reduction
- GA - flex elbow and inwardly rotate to engage anconeus in the olecranon fossa/supratrochlear foramen - extend elbow - check collaterals after reduction (Campbell Test) -> collateral ligaments can be ruptured as a consequence of luxation so check them using this test - often damaged - reduction may not be complete - external support for 1w
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Stifle luxation/dislocation/derangement in the cat - cause
- devastating injury associated with RTA and falls from height and attempting to free limb when trapped
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Stifle luxation/dislocation/derangement in the cat - what gets damaged?
- multiple ligament injuries including collaterals and cruciates - associated damage to menisci and joint capsule
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Stifle luxation/dislocation/derangement in the cat - tx & prognosis
- requires reduction of the joint and stabilisation (transarticular ESF) - reconstruction of the ligaments or prosthesies with screws and washes - sometimes do surprisingly well - if function remains poor then arthrodesis can be employed
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Acquired traumatic luxation - talocrural/hock joint - cause
- often occurs as a result of an RTA - occurs with shear injuries to the medial malleolus where there may be considerable loss of skin and soft tissue - associated with fractures to the malleoli or rupture of the collateral ligaments
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Acquired traumatic luxation - talocrural/hock joint - tx
- GA - malleolar fractures are fixed or ligaments repaired - ligaments need support of it absent then prostheses can be used with nylon anchored too bone screws to mimic the action of the collaterals - if the repair remains unstable a trans-articular fixator can be used
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Salvage procedures - examples
Arthroplasty - excision or replacement of a joint Arthrodesis - surgical fusion of a joint Amputation - removal of limb with or without the placement of an endoprothesis These may result in a mechanical lameness but the pt is pain free The choice depends on many factors including joint affected, surgeons capability and O finances
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Arthroplasties - indications
- grossly dysplastic joints - severe and intractable pain from OA joints - un-reconstructable articular fractures - persistent luxation
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Excision arthroplasties - locations & their prevalence
Hip - common Shoulder - rare as arthrodesis is very successful in this joint TMJ - occasional
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Excision arthroplasties - femoral head and neck ostectomy
- example indication: Perthe's dz - remember anteversion of canine hip - remove all femoral neck - preserve the lesser trochanter - large dogs, esp if overweight -> unpredictable outcome - rehab important in both small and large pts - lots of pain relief and physio afterwards
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Total hip replacement - types & manufacturers
- cemented (polymethacrylate) - cement-less (pressfit) - these have a porous metallic surface which encourages new bone ingrowth - hybrid systems: cementless acetabular component (polyurethane), cemented stem (stainless steel or titanium) - micro- and nano- systems were cemented only but now have a press fit acetabular cup
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Total hip replacement - candidate
- 20-40kg for standard system but now small dogs and cats can be treated - not overweight - no previous sx? - unresponsive to medical management - compliant O and pt
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Total hip replacement - complications
5-10% - lower end for more experience surgeons Infection - surgical - haematogenous (that can occur at any time) Luxation - esp in first 8w Fracture - stress riser at end of femoral stem Aseptic loosening - implant/cement or bone/cement interface
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Elbow, knee and hock replacements
Total elbow - 2 systems currently available and success rates are increasing Total and partial knee - becoming more available and success rates are improving Patella groove replacement - for intractable patella pain associated with cartilage loss to groove and patella Hock replacement - in development, but not widely available atm
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What is arthrodesis?
- the surgical fusion of the joint resulting in pain free movement of the limb
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Principles of arthrodesis
- remove all articular cartilage - place cancellous bone graft or equivalent - rigid fixation preferably under compression - fix at a functional angle
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Which joints do well with arthrodesis?
- shoulders do well - elbows and stifles more difficult to determine correct limb length -> if too long need to circumduct leg, if too short fail to use
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Pancarpal/pan tarsal arthrodesis
Pan meals all In the carpus - antebrachiocarpal - intercarpal - carpometacarpal In the tarsus - talocrural - intertarsal - tarsometatarsal
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Amputation - indications
- comminuted fracture involving joint - neoplasia - extensive loss of soft tissues - paralysis e.g. brachial plexus avulsion - intractable joint pain when finances won't allow joint replacement
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Amputation - ideal candidate
- not overweight - no significant problem with contra-lateral limb - good temperament - committed O
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Amputation - surgical management
- fore or hind quarter amputation or hemipelvectomy -> these are not appropriate if a prosthesis is anticipated - local nerve blocks applied early in the sx - cut nerves with scalpel - reduce dead space - meticulous homeostasis
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Transcutaneous endoprosthesis - what is it? Use?
- prosthesis retained in bone - avoids pain in the stump tissue and proprioceptive problems that arise in people wearing standard prosthetic - difficult to get soft tissues to form seal around metalwork (reindeer antler model) - O more aware of the availability of these prosthesis and despite the problems that may arise they can offer a good QoL for many pets
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Digit amputation - indications
- trauma to digit - neoplasia (SCC or melanoma to nail bed)
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Digit amputation - which digits amputated do well?
- digits III and IV are the main weight bearing structures to the foot - do better with amputation of II and V - can amputate through the joint
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Weight bearing and amputation
- the normal animal carries 40% of weight on hindlimbs and 60% of forelimbs - this changes with amputation - weight is transferred to the other limbs after amputation - the remaining fore or hind limb is moved towards the midline to create a triangular arrangement of the legs - there may be no reason to leave a stump unless prosthesis is anticipate
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Limb sparing surgery - what is it used for? how is it done / options? prognosis?
= a means to manage a tumour, provide analgesia and maintain limb function - primarily an oncological sx - resect bone with appropriate margins - cortical allograft used to maintain limb length (or excised tumour bone pasteurise and replace) - arthrodesis if near joint e.g. distal radius - follow up (neoadjuvant) chemo - complications are frequent particularly infection - median survival times are similar between procedures (amputation vs limb sparing)
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Limb sparing surgery - summary
- improves QoL - a mechanical lameness remains - finances play a large part in the decisions taken by O - outcome depends on pt temperament and O commitment