Ion Channels In Pain Pathway Flashcards
1
Q
Where are Nav 1.8 expressed?
A
DRG and trigeminal ganglia
2
Q
How does carbamazepine, phenytoin and lidocaine work?
A
Carba - stabilised inactivation state of the channel
Phenytoin- stabilised inactivated state
Lido- inhibits open/ inactivated channel
3
Q
How does gabapentin and pregabalin work?
A
Binds to alpha 2 delta
4
Q
Where are Nav 1.7 expressed and what does it do?
A
In DRG and sympathetic ganglion Neurons
Amplifies generator potentials in Neurons expressing it
