ion pumps Flashcards
(24 cards)
what is the purpose of ion pumps
general maintenance of membrane potentials
that are needed later for cotransport, pH balance, signaling, etc
what are the four types of pumps
P,
V,
F,
ABC transporter
which ion pumps are structurally different
p and v
which ion pumps share functional similarity
p and v
which ion pumps are structurally similar
v and f
which ion pumps are functionally different
v and f
which ions pumsp are fucntionally and structurally different
p and f
p type pumps
structurally simple
-has phosphorylated intermediate where the pump is phosphorylated
-results in two confromational states E1 and E2
-used for many different ions- calcium, potassium, sodium, etc
what kind of pump is the na k pump
p type pump
what amino acid is phosphorylated in the na/k pump
asparated in the E1 state
how do v type pumps change and get their energy
by ATP no phosphorylation intermediate
where are v type pumps found
in lysosomes, golgi, secretory vesicles, plant vacoules, and cells that secrete H+
allows them to create an acidic enviroment
what do v type pumps pump
H ions/ protons against htier concentrations gradeint
f type pumps
also pumps h ions like v type pumps but pumps in reverse
generates ATP- ATP synthase
uses H moving down concentration gradient to make ATP
where are f type pumps found
in mitochondria and chloroplasts
ABC superfamilty of pumps
ATP binding cassette
not and ion pump
trasnports phospholipids, lipophilic drugs, cholesterol, and a few other small molecules
can detoxify certain tissues
ABC pumps
ABC pumps fcats
has four subunits, uses ATP energy
what do ABC proteins do
export a wide variety of drugs and toxins from cells
about 50 ABP mamallian proteins
where do ABC proteins localize in eukaryotes
to the plasma and intracellular organelle membranes
-in and out of cells and within cells
where are ABC proteins highly expressed
in liver
kidney
intestines
what do some ABC pumps act as
flipases- flip phospholipids
what ABC proteins contian additional regulatory domtains
cystic fibrosis transmembrane regulator
this is nto actually a pump but a chloride channel
chloride ABC channel where and what it does
the dephosphorylated state is closed facing the inside
phosphorulation removes the r domain gate thingy
ATP binds and it is open changing confromation and chloride can go through
