Ionizing radiation 1 Flashcards Preview

Introduction to Toxicology > Ionizing radiation 1 > Flashcards

Flashcards in Ionizing radiation 1 Deck (29):

how much of ionizng radiation is natural ?

>80% - of what we are exposed to daily


what are different sources of radiation exposure ?

cosmic rays


what is radon ?

causes most of the natural exposure
its a gas present in rocks, soil, water and air


how are we exposed to cosmic rays ?

produced in the galaxy and from the sun


when does your exposure to cosmic rays increase ?

at higher altitudes
- pilots are exposed to more of them
- pilots are thought to be exposed to about 20mSv per year


what is ionizing radiation ?

its a physical toxic agent


what is an example of a food containing lots of radioactive material ?

bananas because they contain lots of potassium


what does it mean by internal exposure to radiation ?

we are radioactive
- we contain carbon-14 and K-40
- sufficient amounts in the body to account for 10% of daily exposure


what is uranium-238 principally found in and what does it degrade into ?

principally in rock
converted to Ra-226 then to Ra-222 then to lead


when were x-rays discovered ?

1895 by roentgrn


what did becquerel observe ?

in 1896 he noticed that uranium salts emit radiation
- due to radioactive isotope


what did bergonie and tribondeau discover in 1906 ?

stem/immature cells are more sensitive than fully differentiated cells
younger tissues and organs are more radiosensitive than their adult equivalents
tissues and organs with the highest metabolic activity are the most radiosensitive
cells with the fastest rates of division are most sensitive- epithelial cells


what did workers with ionizing radiation discover ?

workers discovered that radioactive material could cause harm when handled
- they causes red sore skin and blisters and it also damaged their eyes


when are you most sensitive to ionizing radiation ?

most sensitive as a fetus, then your sensitivity decreases to adulthood and then sensitivity increases in the elderly


what did muller show ?

1927- showed that ionizing radiation is mutagenic in fruit flies


what was discovered in the 1940s?

discovery that ionizing radiation results in free radical generation via hydrolysis of water and that oxygen is a radiosensitizer
- proved the effects of ionizing radiation are caused indirectly


what happened in 1945?

atomic bombs - caused 100000 deaths


what happened in the 1950/60s?

atmosphere testing of nuclear weapons and windscale fire
- windscale fire was when the military reactor caught fire and released a lot of radiation


what happened in 1970/80s?

3 mile island and chernobyl
- chernobyl disaster was when the reactor exploded and release a lot of radiation, 50 people died

- russian authorities didnt provide antidote potassium iodide quickly enough


what can radium paint do ?

it glows in the dark so was used to paint the dials of watches
- used to produce luminous instruments in WW1
- it contains Ra-226 which gives off alpha particles which damage osteoblasts
- women using this paint in ww1 in the us used to use fine paint brushes which they licked to produce a fine tip and this caused them to suffer serious necrosis of jaw bone and many suffered cancer later in life
- radium concentrates in bone


what is 1 gray (Gy)?

1 joule of energy absorbed per kg of tissue


what varies with radiation type ?

biological effects
- same absorbed dose of x-rays and alpha particles produces different levels of damage


what tissue is more likely to absorb ionizing radiation ?

dense tissue such as bone


how much more damaging are alpha particles compared to x-rays ?

20x more damaging per unit of absorbed dose


what affects the biological damage ionizing particles can cause ?

size- the bigger it is the more likely it will interact with particles in cells
kinetics- slower it is the more likley it will interact with particles in cells

therefore alpha particles more readily interact with particles in cell - they are only dangerous to use internally because they cant penetrate the skin due to the dead cells (striatum corneum )


what does it mean by linear energy transfer?

probability that a collision will occur


what is 1 sievert (Sv)?

dose that produces the same biological effect as 1 Gy of x-rays


what distances do alpha particles travel before they cause damage ?

about 4 cm in the air before they collide with another particles and disperse energy
in the body it travels ony 40 micrometers before interactionn


what are the 2 components of ionizing radiation ?

electrical magnetic radiation-