IPRATROPIUM BROMIDE (Atrovent®)

Question 1

Drug Classification

Answer 1

Anticholinergic / Parasympatholytic

Question 2

Mechanism of Action

Answer 2

Muscarinic ACh-R antagonist → inhibits parasympathetic stimulation in bronchial smooth muscle cells, submucosal glands, and goblet cells → dries respiratory tract secretions and allows for bronchodilation

Question 3

Pharmacokinetics

Answer 3

Onset of Action = Varies
Peak Effects = 1.5-2 hours
Duration of Effect = 4-6 hours
Half-Life = 1.5-2 hours

Question 4

Indications/Field use

Answer 4

Asthma/COPD/RAD

Question 5

Contraindications

Answer 5

None

Question 6

Dose

Answer 6

A: 500ug nebulized with oxygen 8LPM q 5 min up to 3 doses

P: same

Question 7

Precautions

Answer 7

Ipratropium bromide should be administered concurrently with albuterol x 3 doses

Question 8

Drug Interactions

Answer 8

None

Question 9

Side effects/Adverse reactions

Answer 9

Palpitations, dizziness, headache, anxiety, nervousness, rash, dry mouth, nausea & vomiting