Iron

Question 1

Function of IRON (Fe)

Answer 1

It is used to transport and store oxygen in blood and store oxygen in
muscles.
It is used in the electrons transport chain which is the principle source
of energy in cells.
It is needed for synthesis of DNA and also required for enzyme involved
is synthesis of collagen, neurotransmitters and hormones.

Question 2

Iron Body content is

Answer 2

4-6gram

Question 3

Body requirement & iron conservation

Answer 3

10mg adult

Pregnant 18 mg

Question 4

Iron excretion is about

Answer 4

0.9 adult

Female 1.3 الدوره

Question 5

Absorption of iron?

Answer 5

1.3 mg/day is absorbed from digested food however the absorption increases during growth and pregnancy.

Question 6

Why some people 4mg absorption of iron

Answer 6

iron deficiency the iron absorption from food increases to 4 mg/day.

Question 7

Iron is absorbed in………. form, which is measurable in blood as free iron.

Answer 7

Ferrous (Fe2+ ) form .

Question 8

What is Transferrin?

Answer 8

Protein bind to iron father re -abdorbtion to transport in the blood and than storage in liver , spleen hepatoparenchymal cells, reticuloendothelial cell and bone marrow. However every transferrin bind to two molecules.

Question 9

Serum iron + amount of iron bound to transferrin =

Answer 9

Total iron in the circulation

Question 10

What is Ferritin

Answer 10

protein having 24 subunits of 500kDa
It binds 4000 iron molecules which accounts for a larger iron storage
Synthesized by cells that store iron and is later used to synthesize heme
Ferritin in serum is derived from the breakdown of macrophages of the
RES (liver, spleen and bone marrow).
Its measurement is used to assess iron stores in the body

Question 11

Low Ferritin levels indicate

Answer 11

indication of iron deficiency

Question 12

Increased Ferritin levels are observed in

Answer 12

Liver disease such as hepatitis, liver cirrhosis due to alcohol consumption and hepatic carcinoma also leukemia, Hodgkin’s
lymphoma and chronic inflammatory disease

Question 13

Ferritin is released from inflamed tissues or in

case of malignancies it’s released by

Answer 13

Tumor

Question 14

Ferritin can be measured by…

Answer 14

RIA, ELISA and Chemiluminescence

Question 15

Type of specimen required for iron

Answer 15

Timing of specimen collection is important
Fasting serum or plasma is used
serum or heparinised plasma tube is suitable
Avoid gross hemolysis