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Flashcards in Iron in Health Deck (10)
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1
Q

Where does the Fe2+ ion sit?

A

in the porphyrin ring

2
Q

Where would a biopsy be taken if needed in:

  • iron deficiency
  • iron overload
A

bone marrow for deficient

liver for overload

3
Q

What is the major negative regulator of iron uptake?

A

Hepcidin

4
Q

How do mucosal factors regulate iron uptake?

A

DMT-1 (divalent metal transporter) at mucosal surface

Ferroportin at serosal surface

5
Q

What Down-regulates ferroportin?

A

hepcidin

6
Q

What Facilitates iron export from the enterocyte?

A

ferroportin

7
Q

What Transports iron into the duodenal enterocyte?

A

DMT-1

8
Q
The following are features of what:
Arthritits
Cirrhosis
Diabetes
Cardiomyopathy
Weakness/fatigue
Joint pains
Impotence?
A

hereditary haemochromotosis

9
Q

Treatment of hereditary haemochromatosis?

A

Weekly phlebotomy

10
Q

Why is family screening so important in haemochromotosis?

A

Haemochromatosis may be asymptomatic until irreversible organ damage has occurred