ISBB - Diseases Associated with other BGS

Question 1

ISBT 002: MNS

Anti-N

Answer 1

renal patient

Question 2

ISBT 002: MNS

En(a-) phenotype: M-N-

Answer 2

Plasmodium falciparum merozoite

Question 3

ISBT 003: P1PK

P antigen has been identified in ___, ___, and ___

Answer 3

hydatid cyst fluid (E. granulosus)
Lumbricoides terrestris (common earth worm)
Ascaris suum

Question 4

ISBT 003: P1PK

Pk antigen is a marker of apoptosis in ___, ___, and ___

Answer 4

germinal center B cells
Burkitt lymphoma
lymphoblastic leukemia

Question 5

ISBT 003: P1PK

Pk antigen is a receptor for Shiga toxins which cause ___ and ___

Answer 5

Shigella dysentery
E. coli-associated hemolytic uremic syndrome (HUS)

Question 6

ISBT 003: P1PK

Pk antigen provides protection against ___ of peripheral blood mononuclear cells

Answer 6

HIV infection

Question 7

ISBT 003: P1PK

Autoanti-P

Answer 7

PCH (paroxysmal cold hemoglobinuria)

Question 8

ISBT 003: P1PK

Anti-P1 is observed in individuals infected with ___; have also been found in patients with ___ (bovine liver fluke disease) and in bird handlers

Answer 8

Echinoccocus granulosus
fascioliasis

Question 9

ISBT 003: P1PK

Anti-PP1Pk is originally called as anti-
(“T” = tumor) was first described in the serum of Mrs. Jay, a p individual with ___ of the stomach

Answer 9

adenocarcinoma

Question 10

ISBT 003: P1PK

Anti-PP1Pk is also associated with ___ in early pregnancy

Answer 10

spontaneous abortions

Question 11

ISBT 003: P1PK

Anti-Pk is associated with ___ and a___

Answer 11

biliary cirrhosis
autoimmune hemolytic anemia

Question 12

ISBT 003: P1PK

P system antigens also serve as receptors for ___ – a cause of UTI

Answer 12

P-fimbriated uropathogenic E. coli

Question 13

ISBT 003: P1PK

P is the receptor of ___

Answer 13

human parvovirus B19

Question 14

ISBT 005: LUTHERAN

Named from the donor Lutheran when an anti-Lu(a) was discovered in serum of a patient with ___ following transfusion

Answer 14

SLE / systemic lupus erythematosus

Question 15

ISBT 005: LUTHERAN

Anti-Lub is implicated with shortened survival of transfused cells and posttransfusion ___

Answer 15

jaundice

Question 16

ISBT 006: KELL

McLeod Syndrome:
~ absence of Xk results
~ associated with ___

Answer 16

chronic granulomatous disease (CGD)

Question 17

ISBT 006: KELL

Patients with ___, in which the autoantibody is directed against a Kell antigen, may have depressed expression of that antigen

Answer 17

autoimmune hemolytic anemia

Question 18

ISBT 006: KELL

Anti-K is associated with ___

Answer 18

severe HDN

Question 19

ISBT 007: LEWIS

Lack of expression of Lewis antigens has been demonstrated on the RBCs of patients with ___, ___, and ___

Answer 19

cancer
alcoholic cirrhosis
viral and parasitic infections

Question 20

ISBT 007: LEWIS

It also causes mild ___

Answer 20

HTR

Question 21

ISBT 008: DUFFY

Fy6 is important for invasion of ___ and ___

Answer 21

Plasmodium vivax
Plasmodium knowlesi

Question 22

ISBT 008: DUFFY

Anti-Fya and anti-Fyb have been associated with ___ & ___

Answer 22

acute HTRs
delayed HTRs

Question 23

ISBT 008: DUFFY

Fy(a-b-)
~ Resist infection in vitro by the monkey malaria organism Plasmodium knowlesi and Plasmodium vivax
~ Has been linked to lower neutrophil counts, susceptibility to ___, ___, and reduced ___ following renal transplantation

Answer 23

infection
renal disease
graft survival

Question 24

ISBT 009: KIDD

Found on Mrs. Kidd whose infant has ___

Answer 24

HDN

Question 25

ISBT 009: KIDD Most common cause of ___

Answer 25

delayed hemolytic transfusion reaction (DHTR)

Question 26

ISBT 010: DIEGO Associated with ___, ___, and southeast Asian ___

Answer 26

hereditary spherocytosis acanthocytosis ovalocytosis

Question 27

ISBT 010: DIEGO Anti-Dia Anti-Dia & Anti-Dib Anti-Wra Autoanti-Wrb Anti-ELO

Answer 27

HDFN (Venezuelan baby) HTRs and HDFN severe HTRs Warm Autoimmune Hemolytic Anemia severe HDFN

Question 28

ISBT 011: CARTWRIGHT ~ Do not cause HDFN ~ Absent from RBCs of people with ___

Answer 28

PNH III

Question 29

ISBT 012: XG ___ is not implicated in HDFN or as a cause of HTRs

Answer 29

Anti-Xga

Question 30

ISBT 013: SCIANNA ~ Not cause of severe ___ ~ Mild ___ (except for one severe case for antiRd for w/c the baby required exchange transfusion)

Answer 30

HTR HDFN

Question 31

ISBT 014: DOMBROCK Anti-Doa and Anti-Dib is not associated with ___, but reported to cause ___

Answer 31

HDN delayed transfusion reactions / delayed HTRs

Question 32

ISBT 015: Colton Anti-Coa Anti-Cob Anti-Co3

Answer 32

HTRs, HDFN HTRs, mild HDFN mild HTR, severe HDFN

Question 33

ISBT 016: Landsteiner-wiener Autoanti-LW is common in serum from patients with ___

Answer 33

warm autoimmune hemolytic anemia

Question 34

ISBT 017: CHIDO/RODGERS

Answer 34

Clinically insignificant for transfusion

Question 35

ISBT 020: GERBICH * Leach Phenotype: ___ * Rh Null Syndrome: ___ * McLeod Phenotype: ___

Answer 35

+ elliptocytes + stomatocytes + acanthocytes

Question 36

ISBT 020: GERBICH Ge Null Phenotype: ___

Answer 36

elliptocytic (mild anemia)

Question 37

ISBT 020: GERBICH Anti-Ge3: ~ ___ ~ ___ (late onset) associated w/ inhibition of erythroid cell growth and early onset of hemolysis

Answer 37

serious HDFN severe anemia

Question 38

ISBT 021: CROMER ~ Do not cause ___ ~ Anti-Cra and Anti-Tca causes ___

Answer 38

HDFN HTRs

Question 39

ISBT 022: KNOPS Clinically insignificant for ___and ___

Answer 39

transfusion HDFN

Question 40

ISBT 023: INDIAN In(a-b-): ___ Anti-Ina and Anti-Inb: ___  Anti-Ina: decreased survival  Anti-Inb: ___

Answer 40

Congenital dyserythropoietic anemia + DAT but no clinical HDFN immediate HTR

Question 41

ISBT 024: OK ___ is a receptor essential for invasion by Plasmodium falciparum

Answer 41

Basigin

Question 42

ISBT 024: OK ~ Causes reduced survival of ___ RBCs injected into original antibody maker, suggesting clinical significance w/c is predicted by in vitro monocyte-monolayer assay ~ No reports of HDFN

Answer 42

Cr-labeled Ok(a+)

Question 43

ISBT 025: RAPH Clinical significance in:

Answer 43

Transfusion

Question 44

ISBT 026: JOHN HAMILTON HAGEN Clinically significant or Clinically insignificant

Answer 44

Clinically insignificant

Question 45

ISBT 027: I Anti-I is a common antibody that can be benign or pathologic Pathologic Anti-I or Autoanti-I: ~ Patients with ___ often develop strong cold agglutinin with I specificity as a cross-reactive response to Mycoplasma antigen

Answer 45

Mycoplasma pneumoniae

Question 46

ISBT 027: I Pathologic Anti-I or Autoanti-I: Listeria monocytogenes organism from a patient with ___ has been reported to absorb anti-I and stimulate its production in rabbits

Answer 46

cold autoimmune hemolytic anemia

Question 47

ISBT 027: I Is associated with much greater i activity

Answer 47

Chronic dyserythropoiesis anemia type II OR Hereditary erythroblastic multinuclearity with a positive acidified serum test (HEMPAS)

Question 48

ISBT 027: I Anti-I is a common antibody that can be benign or pathologic ___: ~ found in the serum of normal healthy adults ~ not associated with an in vivo red cell destruction

Answer 48

Benign Anti-I

Question 49

ISBT 027: I In Asians, the i adult phenotype has been associated with ___

Answer 49

congenital cataracts

Question 50

ISBT 027: I Pathologic Anti-I or Autoanti-I: Associated with ___ disease

Answer 50

cold agglutinin

Question 51

ISBT 027: I Anti-i is associated with ___, alcoholic cirrhosis, ___, and ___

Answer 51

infectious mononucleosis myeloid leukemia reticuloses

Question 52

ISBT 027: I Anti-I^T ~ Have been found in patients with ___, with special association with ___

Answer 52

warm autoimmune hemolytic anemia (WAIHA) Hodgkin’s lymphoma

Question 53

ISBT 029: GILL ~ No clinical ___ ~ Causes ___

Answer 53

HDFN HTR

Question 54

ISBT 030: RHAG Anti-RHAG4: ___

Answer 54

severe HDFN

Question 55

ISBT 031: FORS Human cells that express the FORS1 may have an increased susceptibility to ___ infection

Answer 55

E. coli

Question 56

ISBT 032: JR ~ Severe ___ ~ ___

Answer 56

HDFN HTR

Question 57

ISBT 033: LAN ~ Immediate ___ ~ Not known to cause severe ___

Answer 57

HTR HDFN

Question 58

ISBT 034: VEL ~ Severe immediate ___ ~ Severe ___

Answer 58

HTRs HDFN

Question 59

ISBT 035: CD59 ___: is an acquired hemolytic anemia caused by a mutation in the GPI-linker gene

Answer 59

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Question 60

ISBT 035: CD59 Other causes besides PNH:

Answer 60

Hemolysis Strokes Neuropathy

Question 61

ISBT 036: AUGUSTINE ~ Mild ___ ~ Severe ___

Answer 61

HDFN HTRs

Question 62

LUKE (LKE) ANTIGEN Associated with ___ and metastasis in ___

Answer 62

Hodgkin’s lymphoma renal carcinoma

Question 63

LUKE (LKE) ANTIGEN Decreased expression of the LKE is seen in individuals with the Se gene with secretors having a 3- to 4-fold decreased risk of ___ infections

Answer 63

E. coli