Ischaemic Heart Disease Flashcards
(45 cards)
What’s the difference between stable and unstable angina?
Stable angina - physical exertion or emotional stress, relieved within minutes of rest or GTN
Unstable- new onset angina or abrupt deterioration of stable angina, occurring at rest. Requires hospital admission
What is some lifestyle advice given to patients to manage stable angina?
Smoking cessation
Cardioprotective diet
Achieve and maintain healthy weight
Increase physical activity
Limit alcohol consumption
What drugs are used to treat angina?
Sublingual glyceryl trinitrate - rapid symptom relief
Beta blocker or CCB
2nd line - long acting nitrate (isosorbide mononitrate), Ivabradine, Nicorandil, Ranolazine
What drugs can be given to angina patients for secondary prevention of cardiovascular events?
Antiplatelet treatment - 75mg aspirin
ACEi for people with: coexisting hypertension, heart failure, asymptomatic left ventricular dysfunction, chronic kidney disease, or previous myocardial infarction
HTN and hyperlipidemia treatment if required
When should an angina patient be admitted to hospital?
Pain at rest (which may occur at night).
Pain on minimal exertion.
Angina that seems to be progressing rapidly despite increasing medical treatment
What are some risk factors of angina?
stress
smoking
diabetes
obesity
high cholesterol
high blood pressure
family history of heart disease
older age (45+ for men and 55+ for women).
How is angina diagnosed?
ECG - Pathological Q waves (in particular).
Left bundle branch block (LBBB).
ST-segment and T-wave abnormalities
Exercise stress test
Coronary angiography
Whats the “typical” angina presentation?
-all three of the following features:
Precipitated by physical exertion.
Constricting discomfort in the front of the chest, in the neck, shoulders, jaw, or arms.
Relieved by rest or glyceryl trinitrate (GTN) within about 5 minutes.
How does “Atypical” angina present
-two of the following features:
Precipitated by physical exertion.
Constricting discomfort in the front of the chest, in the neck, shoulders, jaw, or arms.
Relieved by rest or glyceryl trinitrate (GTN) within about 5 minutes.
AND atypical symptoms include gastrointestinal discomfort, and/or breathlessness, and/or nausea
What are factors that would make a stable angina diagnosis less likely?
Pain that is continuous or prolonged.
Pain that is unrelated to activity.
Pain that is brought on by breathing.
Pain that is associated with dizziness, palpitations, tingling, or difficulty swallowing
What is Acute coronary syndromes (ACS)?
a spectrum of conditions which include myocardial infarction with or without ST-segment-elevation (STEMI or NSTEMI respectively), and unstable angina
Result from the formation of a thrombus on an atheromatous plaque in a coronary artery
How is a definitive diagnosis of ACS made?
Clinical presentation
ECG changes
Measurement of biochemical cardiac markers
What is a STEMI?
generally caused by a complete and persistent blockage of the artery resulting in myocardial necrosis with ST-segment elevation seen on the ECG
What non-drug treatments are available for ACS?
PCI or coronary artery bypass graft (CABG) alongside drug treatments
Decision depends on: type of ACS, time since symptom onset, the patient’s clinical condition, comorbidities, and their formally-assessed risk of future cardiovascular events
What’s the initial management for a patient presenting with ACS?
Pain relief - GTN or IV opioids
Loading dose aspirin 300mg
Oxygen if required
Monitor for hyperglycaemias - if higher than 11mmol/L - receive insulin
What is the management of a stemi?
restore adequate coronary blood flow as quickly as possible:
-Coronary reperfusion therapy (either primary PCI or fibrinolysis)
-Aspirin 300mg and 2nd antiplatelet agent (prasugrel, ticagrelor, or clopidogrel)
-For patients undergoing primary PCI with radial access, heparin (unfractionated) should also be given
-For patients undergoing fibrinolysis, an antithrombin agent should be given at the same time
What occurs in NSTEMI and unstable angina?
partial or intermittent blockage of the artery occurs, which usually results in myocardial necrosis in NSTEMI but not in unstable angina
What may ECG show in NSTEMI and unstable angina?
ST-segment depression, T-wave inversion, or may be normal
How can you differentiate between NSTEMI and unstable angina?
High-sensitivity blood tests for serum troponin
Higher in NSTEMI
How is unstable angina and NSTEMI managed?
Reperfusion therapy or medical management
Aspirin 300mg plus second antiplatelet agent (prasugrel, ticagrelor, or clopidogrel)
Antithrombin therapy with fondaparinux sodium UNLESS undergoing immediate coronary angiography
Heparin (unfractionated) may be used as an alternative in patients with significant renal impairment
Patients undergoing PCI should be offered heparin (unfractionated) in the cardiac catheter laboratory
What should all patients be offered following an ACS?
cardiac rehabilitation programme:
-advice for lifestyle changes, stress management and health education
-include healthy eating, reducing alcohol consumption, regular physical exercise, smoking cessation and weight management
Secondary prevention treatment:
-angiotensin-converting enzyme (ACE) inhibitor, a beta-blocker, dual antiplatelet therapy and statin
What are symptoms on an ACS?
Chest pain or discomfort. This is often described as aching, pressure, tightness or burning. Chest pain also is called angina.
Pain that starts in the chest and spreads to other parts of the body. These areas include the shoulders, arms, upper belly area, back, neck or jaw.
Nausea or vomiting.
Indigestion.
Shortness of breath, also called dyspnea.
Sudden, heavy sweating.
Racing heartbeat.
Feeling lightheaded or dizzy.
Fainting.
Unusual fatigue.
What are some risk factors for an ACS?
Smoking
High blood pressure
High blood cholesterol
Diabetes
Physical inactivity
Being overweight or obese
A family history of chest pain, heart disease or stroke