Ischemic Cardiac Conditions Flashcards
(40 cards)
What are the three layers of an arterial wall, starting from outer layer in?
adventitia, media, and intima
Describe how fluid dynamics rules impact myocardial perfusion?
all fluids flow from areas of high pressure to low pressure, and all fluids follow the path of least resistance so if there is an obstruction, they will take the least resistive path around it-> causes blood flow to decrease more distally
What are the 4 major determinants of myocardial blood flow?
- diastolic blood pressure is the primary driving force moving blood into myocardial tissue
- vasomotor tone plays a role in determining volume of blood passed along to tissue
- resistance to flow is commonly caused by atherosclerosis
- LVEDP- the pressure in the L ventricle at the end of diastole, can put an occlusive force on the capillary beds
Which term describes the presence of obstruction but does NOT inhibit heart muscle function?
coronary artery disease
Which term describes obstruction that causes permanent damage to muscle downstream, inhibiting muscle function?
coronary heart disease
What are the modifiable risk factors for heart disease?
smoking, high blood pressure, proper diet, diabetes, high blood cholesterol, physical inactivity, obesity
What are the non-modifiable risk factors for heart disease?
heredity, male sex (earlier age MI risk), increased age (greater than 65 years old)
What can occur in about half the patients with CHD within one hour of symptoms?
sudden cardiac death
Fill in the blank: chronic stable angina is associated with ______
atherosclerosis
Which condition is described as tightness/pressure/ indigestion above the waist that develops with exertional activity and diminishes with rest or nitroglycerin?
chronic stable angina
What is angina?
imbalance in supply and demand of myocardial oxygen
What are the three types of acute coronary syndrome?
unstable angina, acute MI- STEMI AND NON-STEMI
What are clinical clues or signs that would indicate unstable angina?
angina at rest, pts typical angina now occurring at a lower level of activity, deterioration of a previously stable pattern
What is the difference between a STEMI and a Non-STEMI?
stemi is totally occluded due to thrombus or plaque and can be seen as a ST segment elevation on the EKG, a non-stemi is not completely blocked
How long does it take for necrosis to develop in a MI?
15-20 minutes
What are the common sx of MI?
pressure, chest pain that can spread up towards neck, back, jaw, or shoulders, dizzyness, sweating, pallor, SOB, not relieved by nitroglycerin or rest
What condition occurs at rest and is due to a spasm in the coronary arteries due to exposure to the cold weather, stress or smoking?
prinzmetal angina
What condition has pain at rest that worsens with activity, is NOT relieved with nitroglycerin or rest, and responds to anti-inflammatory medications?
pericarditis
How can you differentiate between MI chest pain versus MSK chest pain?
MSK can be palpated, MI cannot
What condition is due to an increased thickness of the connective tissue and decreased compliance of collagen and elastic connective tissue in the vessels?
arteriosclerosis
What condition is an increased in blood flow that increases BP due to a buildup of plaques?
atherosclerosis
What is the gold standard to diagnosis an MI and what is the normal range?
troponin, 0-3.0 is normal
How can you diagnose an MI?
EKG, troponin and creatine kinase levels
Which creatine kinase isoenzyme is the most conclusive of all the CK isoenzymes and what is the abnormal range?
CKMB, abnormal if it is greater than 3%