isomerism and cisplatin Flashcards
how doe stereoisomerism exist
either as optical isomer or ez isomer
what is the definition of stereoisomer
structura formula but atoms arranged differently in space
what is optical isomerism
in non superimposable mirror images
how to form cistrans octahedral complex
you must have two of one ligand and 4 of another ligands so all together 6 onodentate ligands
how are the cis and trans arranged
is cis the identical ligands are 90 to each other
and in trans the identical ligands are 180 opposite each other
cis trans in square planar
the two ligands are identical, and another 2 ligands are identical only occur in ni and plantinum
how to form optical isomerism
three bidentate or one multidentate with no line of symmetry
describe the structure of cisplatin drug
it is a square planar with the formula pt nh32cl2
how is it an anticancer drug
it prevents dna replication by ligand substitution
what is the risk of cisplatin drug
it can also affect dna replication of healthy cells , supressed immune systems hair loss
how do we minimise the risk
by using small doses or localised usage
