Iszard-Pharm of CNS Stimulants

Question 1

• Amphetamine (d,l)
• Dextroamphetamine (Methamphetamine)
• Lisdexamfetamine (pro-drug
• Methylphenidate (d,l) & Dexmethylphenidate

Are what type of ADHD meds?

Answer 1

Stimulants- amphetamine derivatives

Question 2

Atomoxetine, Guanfacine, and Clonidine are what type of ADHD meds?

Answer 2

Non-stimulants

Question 3

What drugs

1. Block presynaptic reuptake of neurotransmitters
2. interference with vesicular monoamine transporter (VMAT)
3. increase in neurotransmitter release (NE, then DA, then 5-HT each at increasing doses)

Answer 3

Stimulants - enhance neurotransmitter transmission by serving as direct and indirect non-catecholamine sympathomimetics

Question 4

Do D-isomers or L- isomers of AMP/MPH have more CNS activity ?

Answer 4

D-isomers of AMP/MPH more CNS activity than mixed or L- isomers,

Question 5

What is the main activity of methylphenidate?

Answer 5

1. inhibition of DA reuptake
2. inhibition of neurotransmitter pre-synaptic uptake
   - does not stimulate the release of neurotransmitters

Question 6

Immediate release Dextroamphetamine /AMP/Adderall is in what form?

Answer 6

Tablet- 4-6 hr duration

-Is an amphetamine based stimulant

Question 7

Immediate release Dextroamphetamine Sulfate/ ProCentra is in what form?

Answer 7

*liquid ** 0 4-6 hr duration

-Is an amphetamine based stimulant

Question 8

Immediate release Amphetamine Sulfate/Eveokeo is in what form?

Answer 8

Capsule- 4-6 hours

-Is an amphetamine based stimulant

Question 9

Immediate release Dextroamphetamine/Zenzidi is in what form?

Answer 9

tablet- 4-5 hr duration

-Is an amphetamine based stimulant

Immediate release dextros are tables, just amphetamine is capsule

Question 10

Extended release Detroamphetamine/adderall XR is in what form?

Answer 10

Capsule - 8-12 hr duration

-Is an amphetamine based stimulant

** all extended release amphetamine based stimulants are capsule EXCEPT Amphetamine Dyanavel XR liquid

Question 11

Extended release dextroamphetamine/Dexedrine is in what form?

Answer 11

capsule- 8-10 hr duration

-Is an amphetamine based stimulant

all extended release amphetamine based stimulants are capsule EXCEPT Amphetamine Dyanavel XR liquid

Question 12

Extended release Amphetamine/ Dyanavel is in what form?

Answer 12

Liquid- 13 hours

-Is an amphetamine based stimulant

Question 13

Extended release Lisdexamfetamine/Vyavanse is in what form?

Answer 13

Capsule 10-12 hr duration
Extended release
-Is an amphetamine based stimulant

Question 14

Extended release Amphetamine (mixed salts)/Mydayis is in what form?

Answer 14

Capsule- 16 hours

Is an amphetamine based stimulant

Question 15

Immediate release Dexmethylphenidate (Focalin) is in what form? What type of drug is this?

Answer 15

Tablet - 4-6 hr

methlyphenidate based stimulant

Question 16

Immediate release methylphenidate/Methylin is in what form? What type of drug is this?

Answer 16

Liquid- 3-4 hrs

methlyphenidate based stimulant

Question 17

Immediate release Methylphenidate/ritalin is in what form? What type of drug is this?

Answer 17

Tablet - 3-4 hours

-methlyphenidate based stimulant

IR are all tab except Methylin which is oral

Question 18

Sustained release methylphenidate/ritalin-SR is in what form? What type of drug is this?

Answer 18

tablet- 4-8 hrs

-methlyphenidate based stimulant

Question 19

Sustained release Methamphetamine/Desoxyn is in what form? What type of drug is this?

Answer 19

Tablet- 4-8 hours

• amphetamine based stimulant

Question 20

Methylphenidate/Aptensio XR® is an extended release drug in what form? Type?

Answer 20

• capsule- 12 hr duration

- methylphenidate based substance

Question 21

Methylphenidate HCl/Concerta® is an extended release drug in what form? Type?

Answer 21

tablet- 10-12 hr duration

– methylphenidate based stimulant

Question 22

Methylphenidate ER/ Comtempla® XR- ODT is an extended release drug in what form? Type?

Answer 22

Tablet- 12 hr duration

– methylphenidate based stimulant

Question 23

Methylphenidate Transdermal/ Daytrana®is an extended release drug in what form? Type?

Answer 23

Transdermal patch; 10-12 hr duration

• – methylphenidate based stimulant

Question 24

Dexmethylphenidate HCl/ Focalin XR® is an extended release drug in what form? Type?

Answer 24

Capsule; 6-10 hr

-methylphenidate based stimulant

Question 25

Methylphenidate HCl/ Metadate CD® is an extended release drug in what form? Type?

Answer 25

capsule- 8-10 hr release --methylphenidate based stimulant

Question 26

Methylphenidate HCL ER/ Ritalin LA® is an extended release drug in what form? Type?

Answer 26

- Capsule - 8-10 hr release | - --methylphenidate based stimulant

Question 27

Methylphenidate HCl/ QuilliChew® is an extended release drug in what form? Type?

Answer 27

- Chewable tablet - 8 hr duration - methylphenidate based stimulant

Question 28

-Methylphenidate/ Quillivant XR®

Answer 28

Liquid -methylphenidate based stimulant

Question 29

What is the main effect of non- stimulant ADHD meds?

Answer 29

Enhances neurotransmitter transmission through: 1. Inhibition of pre-synaptic uptake (atomoxetine) 2. Agonist of CNS alpha 2A adrenergic receptors (guanfacine/clonidine)

Question 30

How do non-stimulant ADHD meds act as agonists of the CNS alpha 2A receptors (ie. guanfacine and clonidine)?

Answer 30

- modulates noradrenergic tone in Prefrontal cortex enhanced by noradrenergic input from the locus coertuleus - direct postsynaptic stimulation of alpha 2A receptors located on the dendritic spines of cortical pyramidal cells--> directly promote functional connectivity of prefrontal cortex

Question 31

What is atomoxetine/Strattera?

Answer 31

An extended release non stimulant ADHD medication in capsule form - metabloliesd by CYP2d6 - can cause ocular irritation id capsule are opened

Question 32

How is Clonidine/Kapvay used in ADHD tx?

Answer 32

- antihypertensive a2 agonist - tablet form - 12-24 hr duration

Question 33

How is Guanfacine/Intuniv used in ADHD Tx?

Answer 33

antihypertensive a2 agonist - tablet form - 12-24 hr duration

Question 34

- Do not crush, chew, or break tablets - Approved for ages 6 years and older - Downward dose titration over 1+ weeks (depending on dose) recommended upon discontinuation to reduce risk of rebound HTN Are warnings for what drugs?

Answer 34

Non stimulants Guanfacine and Clonidine