ITKs toxicités

Question 1

Abemaciclib

Answer 1

Breast
CDK4/6
Diarrhea, fatigue, nausea/vomiting, decreased appetite, abdominal pain, cytopenias, coagulopathy, hepatotoxicity, constipation, arthralgia, stomatitis

Question 2

Afatinib

Answer 2

NSCLC
EGFR, HER2, HER4
**Acneiform rash, **diarrhea, stomatitis, conjunctivitis, hepatotoxicity, interstitial lung disease

Question 3

Alectinib

Answer 3

NSCLC
ALK
Fatigue, constipation, edema, nausea, rash, myalgia and CPK elevation, hepatotoxicity, interstitial lung disease, bradycardia, vision disorders, photosensitivity, hyperglycemia, electrolyte abnormalities, anemia

Question 4

Alpelisib

Answer 4

Breast
PI3K-α
Hyperglycemia, diarrhea, rash, lymphopenia, transaminitis, pneumonitis, increased creatinine

Question 5

Axitinib

Answer 5

RCC
VEGFR-1,2, 3
HTN, fatigue, hand-foot syndrome, hyperglycemia, electrolyte abnormalities, hypothyroidism, diarrhea, proteinuria, creatinine elevations, amylase/lipase elevations, dysphonia, hepatotoxicity

Question 6

Avapritinib

Answer 6

GIST
PDGFR-α
CNS toxicity (cognitive impairment, mood disorders, speech disorders, hallucinations), edema, rash, hair discoloration, electrolyte abnormalities, nausea, elevated LFTs, lacrimation

Question 7

Binimetinib

Answer 7

Melanoma
MEK
Arthralgia, rash, pruritus, photosensitivity, fatigue, nausea/vomiting, diarrhea, cardiotoxicity, ocular toxicity, hyperglycemia

Question 8

Brigatinib

Answer 8

NSCLC
ALK, ROS1
**Interstitial lung disease, HTN, bradycardia, visual disturbance, **SPK elevation, pancreatic enzyme elevation, **hyperglycemia

Question 9

Cabozantinib

Answer 9

Medullary Thyroid, RCC, HCC
VEGFR-1,2,3, MET, RET
HTN, fatigue, hand-foot syndrome, hair color changes, rash, diarrhea, mucositis, decreased appetite, nausea/vomiting, electrolyte abnormalities, cytopenias, hepatotoxicity, creatinine increases,
BB : hemorrhage, GI perforation

Question 10

Capmatinib

Answer 10

NSCLC
MET
Hepatotoxicity, interstitial lung disease, edema, increased creatinine, decreased albumin, increased amylase/lipase, photosensitivity

Question 11

Ceritinib

Answer 11

NSCLC
ALK, ROS1
Hepatotoxicity, diarrhea, nausea/vomiting, fatigue, elevated lipase, hypophosphatemia, hyperglycemia, neuropathy, decreased hemoglobin, creatinine elevations, visual disturbance, **QTc prolongation

Question 12

Cobimetinib

Answer 12

Melanoma
MEK
Nausea/vomiting, diarrhea, pyrexia/chills, photosensitivity, rash, HTN, hemorrhage, vision
impairment, hepatotoxicity, cardiomyopathy (decreased LVEF), hypophosphatemia, cytopenias, retinal vein occlusion, rhabdomyolysis, cutaneous squamous cell carcinoma, creatinine elevations, fever

Question 13

Crizotinib

Answer 13

NSCLC
ALK, ROS1
Nausea, diarrhea, **visual disturbances, edema, bradycardia, hepatotoxicity, fatigue, neuropathy, hypophosphatemia, hypokalemia, decreased GFR, cytopenias, upper respiratory infection, **QTc prolongation

Question 14

Dabrafenib

Answer 14

Melanoma, NSCLC, thyroid
BRAF
Cutaneous squamous cell carcinoma, arthralgia, rash, pruritus, photosensitivity, fatigue, nausea/vomiting, diarrhea, cardiomyopathy, ocular toxicity, hyperglycemia

Question 15

Dacomitinib

Answer 15

NSCLC
EGFR
Le + toxique
Hair loss, nail changes, stomatitis, nausea/vomiting, constipation, myalgia, hyperglycemia, diarrhea, rash, cough

Question 16

Encorafenib

Answer 16

Melanoma, colorectal cancer
BRAF
Arthralgia, cutaneous squamous cell carcinoma rash, pruritus, photosensitivity, fatigue, nausea/vomiting, diarrhea, ocular toxicity, hyperglycemia

Question 17

Entrectinib

Answer 17

NSCLC, Solid tumors w/NTRK fusion
ROS1, ALK, NTRK
Edema, fatigue, constipation, anemia, neutropenia, thrombocytopenia, increased serum creatinine, diarrhea, myalgia, **visual disturbance, **QTc

Question 18

Erdafitinib

Answer 18

Bladder
FGFR
Fatigue, hand/foot syndrome, stomatitis, diarrhea, nausea/vomiting, arthralgia, increased AST/ALT, anemia, thrombocytopenia

Question 19

Erlotinib

Answer 19

SCLC, Pancreatic
EGFR
Fatigue, **rash, pruritus, diarrhea, mucositis, stomatitis, anemia, conjunctivitis, keratoconjunctivitis sicca, cough, hepatotoxicity

Question 20

Everolimus

Answer 20

Metastatic Breast, pNET, RCC, SEGA
mTOR
Mucositis, rash, nausea, edema, cytopenias, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, infection, electrolyte abnormalities, urinary tract infection and infection (BB), creatinine increases, art

Question 21

Gefitinib

Answer 21

NSCLC
EGFR
Acneiform rash, diarrhea, conjunctivitis, hepatotoxicity, GI perforation, interstitial lung disease, eye disease, cough, fever

Question 22

Imatinib

Answer 22

ALL, CML, GIST, MDS
BCR-ABL, C-KIT, PDFGR
Edema, fatigue, insomnia, rash, cytopenias, hepatotoxicity, muscle cramps and pain, arthralgia, myalgia, periorbital edema, increased lacrimation, creatinine increases, cough, fever

Question 23

Lapatinib

Answer 23

Metastatic Breast
EGFR (HER-1), HER-2
Acneiform rash, diarrhea, hepatotoxicity, cardiotoxicity (LVEF decline), dyspnea, epistaxis, insomnia, QTc prolongation

Question 24

Larotrectinib

Answer 24

Solid tumors w/NTRK fusion
NTRK gene fusion
Neurotoxicity, nausea/vomiting, anemia, neutropenia, fatigue, increased AST/ALT, cough

Question 25

Lenvatinib

Answer 25

Thyroid, RCC, endometrial VEGFR-1,2,3, PDGFR, KIT, RET HTN, fatigue, peripheral edema, diarrhea, stomatitis, decreased appetite, arthralgia/myalgia, hand-foot syndrome, dysphonia, headache, proteinuria, urinary tract infection, hemorrhage, arthralgia, myalgia, cough, epistaxis, renal insufficiency, hyperkeratosis, increased amylase/lipase, hepatotoxicity

Question 26

Neratinib

Answer 26

EGFR, HER2 Breast Diarrhea, hepatotoxicity, stomatitis, dyspepsia, transaminitis, nail disorders

Question 27

Niraparib

Answer 27

Ovarian PARP Fatigue, peripheral edema, rash, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, dyspepsia, headache, dysgeusia, insomnia, urinary tract infection, cytopenias, musculoskeletal pain, myalgia, cough, dyspnea

Question 28

Olaparib

Answer 28

Ovarian, Breast, CRPC PARP, homologous recombination repair Fatigue, peripheral edema, rash, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, dyspepsia, headache, dysgeusia, urinary tract infection, cytopenias, musculoskeletal pain, myalgia, , upper respiratory infection,cough, dyspnea

Question 29

Osimertinib

Answer 29

NSCLC EGFR Acneiform rash, diarrhea, conjunctivitis, interstitial lung disease, **QTc prolongation, **cardiomyopathy, fatigue, hyponatremia, hypermagnesemia, cytopenias, eye disorder, cough, venous thromboembolism, pneumonia

Question 30

Palbociclib

Answer 30

Metastatic Breast CDK4/6 Cytopenias, upper respiratory infection, nausea, stomatitis, diarrhea, fatigue, decreased appetite, alopecia, rash, neuropathy, fever, blurred vision, increased lacrimation, dysgeusia, pulmonary embolism

Question 31

Pazopanib

Answer 31

RCC, Sarcoma EGFR, PDGFR, C-KIT Hypertension, diarrhea, nausea, fatigue, hand-foot syndrome, neutropenia/thrombocytopenia, cardiotoxicity (LVEF decline and QTc prolongation) hypothyroidism, hair discoloration, hepatotoxicity, dyspnea, dysphonia

Question 32

Pemigatinib

Answer 32

Cholangiocarcinoma FGFR Occular toxicity, hyperphosphatemia, alopecia, nail disorders, hand-foot syndrome, transaminitis, arthralgia, increased creatinine

Question 33

Pexidartinib

Answer 33

Tenosynovial giant cell tumor CSF1R, KIT, FLT3 Hepatotoxicity, edema (including periorbital), hypertension, hair discoloration, increased LDH, increased cholesterol, dysgeusia, myelosuppression

Question 34

Regorafenib

Answer 34

Colon, GIST VEGFR-1,2,3, KIT, RET, PDGFR, BRAF Hypertension, fatigue, hand-foot syndrome, diarrhea, mucositis, hemorrhage, impaired wound healing, GI perforation, hepatotoxicity, proteinuria, dysphonia, alopecia, electrolyte abnormalities, hypothyroidism, cytopenias, hepatotoxicity (BB), fever

Question 35

Ribociclib

Answer 35

Breast CDK4/6 Fatigue, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, cytopenias, creatinine increases, upper respiratory infection, cough, dyspnea, hepatotoxicity, creatinine increases

Question 36

Ripretinib

Answer 36

GIST PDGFR, KIT, VEGFR2, BRAF Hypertension, edema, alopecia, hand-foot syndrome, diarrhea, transaminitis, arthralgia, dyspnea, cardiotoxicity, increased CPK, increased INR, prolonged aPTT

Question 37

Rucaparib

Answer 37

Ovarian, CRPC PARP Fatigue, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, dyspepsia, dysgeusia, cytopenias, myalgia, creatinine increases, upper respiratory infection, cough, dyspnea, hepatotoxicity, creatinine increases

Question 38

Selpercatinib

Answer 38

NSCLC, thyroid RET, VEGFR Hypertension, hepatoxicity, QT prolongation, hemorrhage, hypersensitivity, hypertension, edema, diarrhea, hypothyroidism, leukopenia, thrombocytopenia

Question 39

Selumetinib

Answer 39

NF-1 MEK CPK elevations, cardiotoxicity, bleeding, dermatologic toxicity, diarrhea, stomatitis, nausea/vomiting, ocular disorders, pyrexia,

Question 40

Sonidegib

Answer 40

Basal Cell Carcinoma Hedgehog pathway Fatigue, alopecia, hyperglycemia, weight loss, hepatotoxicity, elevated amylase/lipase, dysgeusia, diarrhea, anemia, lymphocytopenia, elevated CPK, muscle spasm, musculoskeletal pain, creatinine increases, pruritus, embryofetal death (BB)

Question 41

Sorafenib

Answer 41

RCC, Hepatocellular, Thyroid PDGFR, VEGFR, RAF HTN, diarrhea, nausea, fatigue, hand-foot syndrome, neutropenia/thrombocytopenia, cardiotoxicity (LVEF decline and QTc prolongation) hypothyroidism, hair discoloration, hepatotoxicity, hypophosphatemia, hypocalcemia, voice disorder, peripheral neuropathy, elevated amylase/lipase, stomatitis

Question 42

Sunitinib

Answer 42

RCC, GIST, pNET PDGFR, VEGFR HTN, diarrhea, nausea, fatigue, hand-foot syndrome, rash, neutropenia/thrombocytopenia, cardiotoxicity (LVEF decline and QTc prolongation) hypothyroidism, hair and skin discoloration, hepatotoxicity, mucositis, glossalgia, hyperglycemia, creatinine increases, electrolyte abnormalities, cough, dyspnea, fever

Question 43

Talazoparib

Answer 43

Breast PARP Fatigue, rash, nausea/vomiting, diarrhea, abdominal pain, decreased appetite, dyspepsia, headache, dysgeusia, cytopenias, musculoskeletal pain, myalgia, cough, dyspnea

Question 44

Temsirolimus

Answer 44

RCC mTOR Mucositis, rash, nausea, edema, cytopenias, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, hypophosphatemia, hypokalemia, nail disease, pruritus, hepatotoxicity, infection, weakness, back pain, arthralgia, creatinine increases, fever, dyspnea, cough, conjunctivitis

Question 45

Trametinib

Answer 45

Melanoma, NSCLC, thyroid MEK Hypertension, cardiomyopathy (decreased LVEF, CHF), nausea, diarrhea, fatigue, rash, peripheral edema, lymphedema, acneiform rash, hand-foot syndrome, hypoalbuminemia, stomatitis, anemia, hemorrhage, hepatotoxicity

Question 46

Tucatinib

Answer 46

Breast HER2 Diarrhea, hepatotoxicity, hand-foot syndrome, rash, stomatitis, increased creatinine

Question 47

Vandetanib

Answer 47

Medullary Thyroid EGFR, VEGFR, RET Hypertension, QTc prolongation (BB), CHF, acneiform rash, diarrhea, colitis, fatigue, hepatotoxicity, hemorrhage, photosensitivity, ocular toxicity, hypocalcemia, hypoglycemia, creatinine increases, upper respiratory tract infection, depression

Question 48

Vemurafenib

Answer 48

Melanoma BRAF Cutaneous squamous cell carcinoma, arthralgia, myalgia, rash, pruritus, hyperkeratosis, alopecia, peripheral edema, photosensitivity, fatigue, nausea/vomiting, diarrhea, QTc prolongation, hepatotoxicity, ocular toxicity, creatinine increases, cough, fever

Question 49

Vismodegib

Answer 49

Basal Cell Carcinoma Hedgehog pathway Fatigue, arthralgia, muscle spasms, alopecia, dysgeusia, ageusia, nausea/vomiting, diarrhea, weight loss, decreased appetite, amenorrhea, hyponatremia, hypokalemia, azotemia, embryofetal death (BB)

Question 50

Bevacizumab

Answer 50

Cervical, Colon, Glioblastoma, NSCLC, Ovarian, RCC VEGFR Hypertension, proteinuria thromboembolism, fatigue, hyperglycemia, abdominal pain, hemorrhage, gastrointestinal hemorrhage, postop wound complication

Question 51

Ziv-aflibercept

Answer 51

Colon VEGFR Hypertension, fatigue, voice disorder, hand-foot syndrome, weight loss, diarrhea, stomatitis, decreased appetite, abdominal pain, proteinuria, cytopenias, hemorrhage, hepatotoxicity, infection, weakness, creatinine increases, epistaxis, dyspnea, thromboembolic events, hyperpigmentation, hemorrhoids, urinary tract infection, oropharyngeal pain, rhinorrhea

Question 52

Tepotinib

Answer 52

``` NSCLC IV MET exon 4 skipping MET inh Hépatotox Interstitial lung disease + pneumonite Toxicité embryo-foetale ```

Question 53

Lorlatinib

Answer 53

ALK inh NSCLC | Hyperchol, HyperTG, ILD, Pneumonite, Hépatotox

Question 54

Sotorasib

Answer 54

NSCLC KRAS G122C 2e ligne Inh RAS GTPase Hépatotox, ILD, pneumonite