JUST Weddle's Cancer Regimens (I am so tired SOS)

Question 1

HER2+ drug regimen for non-metastatic breast cancer (2 possibilities)

Answer 1

• DOCEtaxel + CARboplatin + TRAStuzumab + PERtuzumab
• PAClitaxel + TRAStuzumab

Question 2

HER2- chemotherapy regimen for non-metastatic breast cancer (2 possibilities)

Answer 2

• DOXorubicin + CYClophosphamide + PAClitaxel
• DOCEtaxel + CYClophosphamide

Question 3

Chemo regimen for stage III low-risk colon cancer

Answer 3

CapeOx 3 months

Question 4

Chemo regimen for stage III high-risk colon cancer

Answer 4

FOLFOX 6 months

Question 5

Chemotherapy regimens for metastatic colon cancer (3 possibilities)

Answer 5

• FOLFOX +/- bevacizumab
• CapeOx +/- bevacizumab
• FOLFIRI +/- bevacizumab

Question 6

Treatment options for localized prostate cancer (3 possibilities)

Answer 6

• active surveillance
• radiation
• surgery

Question 7

Treatment options for m₀HSPC (2 possibilities)

Answer 7

• observation
• ADT (LHRH)

Question 8

Treatment options for m₀CRPC

Answer 8

ADT + enza/apa/darolutamide

Question 9

Drug regimens for low-volume m₁HSPC (four possibilities)

Answer 9

• ADT
• ADT + abiraterone + prednisone
• ADT + enza/apalutamide
• Sipuleucel T

Question 10

Drug regimens for high-volume m₁HSPC (4 possibilities)

Answer 10

• ADT
• ADT + abiraterone + prednisone
• ADT + enza/apalutamide
• ADT + docetaxel

Question 11

Drug regimens for m₁CRPC (there’s a ton of options ngl)

Answer 11

ADT continued, plus:

• sipuleucel T
• docetaxel
• carbazitaxel
• radium-223
• mitoxantrone
• abiraterone + prednisone
• enzalutamide
• genomic testing

Question 12

Treatment regimen for limited SCLC

Answer 12

RT + cisplatin + etoposide

Question 13

Treatment regimen for extensive SCLC

Answer 13

duvalumab/atezolizumab + carboplatin + etoposide

Question 14

Drugs to be used if SCLC relapse < 6 months (3 possibilities)

Answer 14

• PO/IV topotecan
• lurbinectidin
• clinical trial

Question 15

Treatment regimen for NSCLC resectable + non-squamous

Answer 15

surgery + cisplatin + pemetrexed

Question 16

Treatment regimen for NSCLC resectable + squamous (2 possibilities)

Answer 16

• surgery + cisplatin + gemcitabine
• surgery + cisplatin + docetaxel

Question 17

Treatment regimen for NSCLC unresectable + non-squamous (4 possibilities)

Answer 17

• carboplatin + pemetrexed + RT
• cisplatin + pemetrexed + RT
• carboplatin + paclitaxel + RT
• cisplatin + etoposide + RT

Question 18

Treatment regimen for NSCLC unresectable + squamous (2 possibilities)

Answer 18

• paclitaxel + carboplatin + RT
  
  • etoposide + cisplatin + RT

Question 19

Drug for NSCLC unresectable maintenance

Answer 19

durvalumab

Question 20

Metastatic NSCLC EGFR mutant

Answer 20

osimertinib

Question 21

Metastatic NSCLC ALK mutant

Answer 21

alectinib

Question 22

Metastatic NSCLC ROS-1 mutant

Answer 22

crizotinib

Question 23

Metastatic NSCLC BRAF mutant

Answer 23

dabrafenib + trametinib

Question 24

Metastatic NSCLC NTRK mutant

Answer 24

larotrectinib

Question 25

Metastatic NSCLC RET mutant

Answer 25

selpercatinib

Question 26

Metastatic NSCLC MEK14 mutant (2 possibilities)

Answer 26

* capmatinib * tepotinib

Question 27

Metastatic NSCLC KRAS G12C mutant

Answer 27

sotorasib

Question 28

Metastatic NSCLC + non-squamous + PD-L1 \> 50%

Answer 28

cemiplimab

Question 29

Ideal 3-drug combo for metastatic NSCLC + squamous

Answer 29

pembrolizumab + carboplatin + paclitaxel

Question 30

Metastatic NSCLC + non-squamous

Answer 30

carboplatin + pemetrexed + pembrolizumab

Question 31

Drug regimen for stage III melanoma (3 possibilities)

Answer 31

* nivolumab * pembrolizumab * dabrafenib/trametinib (if BRAF mutant)

Question 32

Metastatic PD-1 positive melanoma (2 possibilities)

Answer 32

* nivolumab * pembrolizumab

Question 33

Metastatic BRAF-positive melanoma (3 possibilities)

Answer 33

* dabrafenib + trametinib * vemurafenib + cobimetinib * encorafenib + binimetinib

Question 34

Chemotherapy regimen for MOST ovarian cancers

Answer 34

paclitaxel + carboplatin

Question 35

Chemotherapy regimen for stage IIIC ovarian cancer

Answer 35

IP cisplatin + paclitaxel (also an IV dose of paclitaxel but who cares)

Question 36

Maintenance PARP drug for BRCA ovarian cancer

Answer 36

olaparib

Question 37

Maintenance PARP drug for ovarian cancer regardless of BRCA status

Answer 37

niraparib

Question 38

Regimen for stage IA/IB seminomatous testicular cancer (assume orchiectomy has already happened) (3 possibilities)

Answer 38

* surveillance * radiation * carboplatin

Question 39

Regimen for stage IIA/IIB seminomatous testicular cancer (assume orchiectomy has already happened) (3 possibilities)

Answer 39

* radiation with iliac lymph nodes * BEP x 3 * EP x 4

Question 40

Regimen for stage IIC/III good-risk seminomatous testicular cancer (assume orchiectomy has already happened) (2 possibilities)

Answer 40

* BEP x 3 * EP x 4

Question 41

Regimen for stage IIC/III intermediate- or poor-risk seminomatous testicular cancer (assume orchiectomy has already happened) (2 possibilities)

Answer 41

* BEP x 4 * VIP x 4

Question 42

Regimen for stage IA/IB non-seminomatous testicular cancer (assume orchiectomy has already happened) (3 possibilities)

Answer 42

* surveillance * RPLND * BEP x 1

Question 43

Regimen for stage IIC/III good-risk non-seminomatous testicular cancer (assume orchiectomy has already happened) (2 possibilities)

Answer 43

* BEP x 3 * EP x 4

Question 44

Regimen for stage IIA/IIB non-seminomatous testicular cancer (assume orchiectomy has already happened) (3 possibilities)

Answer 44

* RPLND * BEP x 3 * EP x 4

Question 45

Regimen for stage IIC/III intermediate- or poor-risk non-seminomatous testicular cancer (assume orchiectomy has already happened) (2 possibilities)

Answer 45

* BEP x 4 * VIP x 4

Question 46

What does BEP stand for?

Answer 46

bleomycin, cisplatin, etoposide

Question 47

What does VIP stand for?

Answer 47

etoposide, ifosfamide (+ mesna), cisplatin