KC Trauma Flashcards
(248 cards)
What is the definition of massive transfusion. What is predictive of requiring an MTP?
> 10 u of pRBCs over 24 hours
Predictive with 2+ of: penetrating injury, +ve FAST, SBP <90, HR >120
Describe a balanced transfusion protocol in adults and pediatrics?
Adults 1:1:1 ratio of pRBCs, platelets, plasma, or 2:1:1
Peds 10 ml/kg:10 ml/kg/25 ml/kg pRBC, platelets, FFP
*10 each for kids probably fine - varied sources not in Rosens
Summarize the literature used to dervive massive transfusion ratios
PROPPR (JAMA 2015)
Bottom line: Among patients with trauma suffering hemorrhagic shock, there was no difference in mortality at 24 hours or 30 days between a 1:1:1 and 1:1:2 administration of plasma, platelets, and red blood cells.
Population: 690 patients at 12 Level 1 trauma centres in NA. Multisite RCT. Inclusion: trauma from field, at least 1 u PRBC, espected to need massive transfusion. Exclusion: Trauma from another facility, expected to die within 1 hour, already received 3uPRBC, pregnant, younder than 15, thoracotomy, more than 5 mins cpr
Intervention: 1:1:1
Control: 1:1:2
Outcome: Primary 24h + 30 day mortality; no difference. Secondary outcomes of hemostasis time, vent free days, surgery, adverse events; no difference. Rate of death due to exsanguination was 9.2% in 1:1:1 vs. 14.6% in 1:1:2 which WAS statistically significant
What are the indications for trauma team activation
Note: guidelines likely differ depending on province and EMS trauma activation protocols:
- Physiologic: GCS <13, systolic <90, RR <10 or >30
- Anatomic: open or depressed skull fracture, penetrating anywhere except the distal extremities, chest wall deformity, pelvic fracture, two or more proximal long bone fractures, pulseless extremity, amputation proximal to wrist or ankle
- Mechanism: falls >20 feet (children 2-3x height of child), high risk auto crash (intrusion, ejection, death in vehicle), auto vs. pedestrian/bicyclist >30 km/hr, motorcycle crash
- Population: older adults, children, patients with bleeding disorder, burns, pregnancy
List 6 side effects of massive transfusion
Hypothermia, hypomagnesium, hypocalcemia (calcium forms complexes with citrate in blood), hypo OR hyperkalemia, alkalosis (from citrate), coagulopathy (due to hemodilution)
Summarize the CRASH 2 trial
CRASH 2 (Lancet, 2010)
Bottom line: TXA improves survival when given early in trauma with known or suspected significant hemorrhage
Population: 20,207 trauma patients with or at risk for hemorrhage, 274 hospitals in 40 countries, multicentre RCT. Exclusion: clear indication or contraindication for TXA
Intervention: TXA 1 g over 10 mins then 1g/8 hour infusion
Control: matching placebo
Outcome: Primary death in hospital at 4 weeks 14.5% in TXA vs. 16.0% in placebo STATISTICALLY SIGNIFICANT. No change in secondry outcomes, incuding VTE, surgical intervention, need for transfusion, death due to bleeding or specific causes
*What are 3 acute complications that can result from mild traumatic head injuries/repeated head injuries?
- Post-concussive syndrome
- Seizures
- Post-traumatic transient cortical blindness
- Impairment in
- physical (headache, dizziness, vertigo, nausea, fatigue, sensitivity to noise & light),
- cognitive (difficulties with attention, concentration, and memory), and
- psychosocial functioning (irritability, anxiety, depression, emotional lability)
Definition of mild traumatic brain injury
GCS 13-15 with a transient disruption in 1) loss of consciousness 2) loss of memory of the events 3) alterations in mental state at the time of accident 4) focal neurologic deficit
LOC <30 minutes, Loss of memory <24 hours, altered can be confused or “seeing stars”
Definition of moderate and severe brain injury
Moderate 9-12, severe <8
*6 Steps in return to play for an athlete suffering a concussion.
- Stage 1/ No activity: Symptom-limited physical and cognitive rest
- Stage 2/ Light aerobic exercise: Walking, stationary cycling
- Stage 3/ Sport-specific exercise: Running drills, no contact
- Stage 4/ Non-contact training drills: Passing drills in football, no contact
- Stage 5/ Full-contact practice: Normal training activities, after medical clearance
- Stage 6/ Return to play: Normal game play
*Young man falls from roof at a party. Three abnormalities on CT given 3 slices (apparently very obvious)
- epidural hemorrhage
- Skull fracture
- Midline shift / loss of ventricles
*He is muttering incomprehensible words, opens his eyes to command, and withdraws to pain. What’s his GCS
E3 V3 M4
*Head trauma, dilated pupil with contralateral paresis. What type of herniation is this?
Uncal herniation
The uncus herniates medially into the tentorial notch, causing compression on the 3rd nerve then brainstem as it progresses:
- Ipsilateral blown pupil/CN III palsy (anisocoria, ptosis, impaired extraocular movements)
- Consciousness, decreased
- Hemiparesis, contralateral
Mnemonic = ICH
Mnemonic = ICH
*Head trauma, If they had ipsilateral CN3 and paresis, describe how this could happen?
Kernohan’s notch syndrome: contralateral cerebral peduncle is forced against the opposite edge of the tentorial hiatus giving ipsilateral paresis - “false localizing”
*Four treatments for increased ICP
- Raise head of the bed (30 degrees), remove constricting devices ex. C collar
- Osmotically active agent — mannitol 1g/kg or hypertonic saline (3%) 300ml
- Intubate and hyperventilate, target PaCO2 35 (although not good evidence)
- Neurosurgical consult for decompressive craniotomy or EVD to relieve pressure
*Recognize SDH and explain pathophysiology
Bleeding between dura and brain, from acceleration-deceleration injuries (bridging vessels), often in elderly/alcoholics with brain atrophy
*Recognize EDH and explain pathophysiology
bleeding between inner skull and dura, from direct trauma (venous or arterial), usually young people
*For SDH describe the following:
i. Does this injury cross the midline
ii. What is the shape?
iii. Does it respect the suture?
- usually not (under dura can not cross falx)
- Crescent moon
- Cross sutures
Surgical indications for OR in SDH
Thickness >10 mm
Midline shift >5 mm
Worsening GSC by >2
Persistently high ICP
Pupil change
*For EDH describe the following:
i. Does this injury cross the midline
ii. What is the shape?
iii. Does it respect the suture?
- May cross midline (above the dura)
- Biconvex, lenticular
- Does not cross sutures
Surgical indications for OR in EDH
Volume >30 cm3
Thickness >15 mm
Midline shift >5mm
Pupil change + coma
Explain the Canadian CT head rule
CT head required in Minor head injury plus:
1. GCS score < 15 at 2 hrs after injury
2. Suspected open or depressed skull fracture
3. Any sign of basal skull fracture (hemotympanum, racoon eyes, CSF otorrhea/rhinorrhea, battle sign)
4. Vomiting ≥ 2 episodes
5. Age ≥ 65 years
6. Amnesia before impact ≥ 30 min
7. Dangerous mechanism ** (pedestrian, occupant ejected, fall from elevation >3 ft or 5 stairs)
Inclusion criteria: minor head injury (blunt trauma to the head with a witness LOC, amnesia, or disorientation), initial GCS => 13, injury within 24 hours
Exclusion criteria: age <16, minimal head injury (no LOC, amnesia, or disorentation), unclear hx of trauma (ex. seizure of syncope), obvious penetrating skull injury or depressed skull fracture, acute focal neurologic deficit), unstable vital signs, seizure, bleeding disorder, return for the same head injury, pregnant
List when the Canadian CT head rule does not apply
See above
What is normal ICP? What is considered high? What is our target MAP in resuscitation with a known high ICP?
5-15mmHg
Remember MAP - ICP = CPP
Between MAP of 60 and SBP of 150 brain undergoes autoregulation
CPP < 40 = lose of autoregulation
so if ICP is 20, want MAP of 80 to have CPP of 60