Key Antibodies to Specific Diagnoses

Question 1

SLE

Answer 1

Anti-dsDNA

Question 2

PBC

Answer 2

Anti-mitochondrial antibodies (AMA)

Question 3

Chronic active hepatitis

Answer 3

Anti-smooth muscle antibody (ASMA)

Question 4

UC and PSC

Answer 4

pANCA

Question 5

Wegner’s granulomatosis

Answer 5

cANCA

Question 6

Coeliac

Answer 6

Anti-endomysial/ gliadin/ transglutaminase

Question 7

CREST/ scleroderma

Answer 7

Anti-centromere

Question 8

Sjogren’s syndrome

Answer 8

Anti-Ro and Anti-La

Question 9

Polymyositis

Answer 9

Anti-Jo

Question 10

Autoimmune hepatitis

Answer 10

Antinuclear antibody (ANA), anti-smooth muscle antibody (SMA)
Liver kidney microsomal antibody (LKM)
Anti-SLA (antibodies against soluble liver antigen)

Question 11

Rheumatoid arthritis

Answer 11

Anti-CCP (anti-cyclic citrullinated peptide)
Rheumatoid factor (RF)

Question 12

Hashimoto’s thyroiditis

Answer 12

Antithyroid peroxidase antibody or TPO Ab

Antimicrosomal antibody

Question 13

Autoimmune thyroiditis

Answer 13

Antithyroglobulin Antibody or TG Ab

Question 14

Grave’s disease

Answer 14

Thyroid Stimulating Immunoglobulin or TSI Ab

Question 15

Chickenpox - Varicella zoster virus (VZV)

Answer 15

IgM and IgG antibodies are measured to look for antibodies suggesting previous VZV infection and immunity.

Initial infection leads to the production of IgA, IgG and IgM antibodies. IgG remains high for many years after initial infection and may provide some immunity to repeated infection. The IgM response usually falls after several months

Immunocompromised and pregnant women require prophylaxis with zoster immune globulin (ZIG) and treatment with aciclovir