Key assets in MM

Question 1

Abecma: INN, company, MoA and Target

Answer 1

ide-cel, BMS, CAR-T, BCMA

Question 2

Abecma: what is it approved in?

Answer 2

5L+ RRMM

Question 3

Abecma: what trial gained its approval and when?

Answer 3

Phase 2 KarMMa trial, 2021

Question 4

Mezigdomide: company, MoA

Answer 4

BMS, CELMOD

Question 5

What drugs are approved in 5L+ RRMM (Drug names + INNs)

Answer 5

Blenrep (belantamab mafadorin), Abecma (ide-cel), Carvykti (cilta-cel)

Question 6

What drugs are approved in NDMM (TI)(Drug name + INN)

Answer 6

Darzalex, daratumumab

Question 7

What combinations are approved in 2L+ RRMM

Answer 7

XVd, Dara+Pd, Dara +Kd, IsaKd

Question 8

What combination is approved in 3L+ RRMM

Answer 8

Isa + Pd

Question 9

What combinations are approved in 2L+ including Amgen’s Kyprolis?

Answer 9

DKd, IsaKd

Question 10

Empliciti: INN, company, MoA and target

Answer 10

elotuzumab, BMS, CS1 mAb

Question 11

Iberdomide: company, MoA

Answer 11

BMS, CELMOD

Question 12

Pomalyst: INN, company, MoA

Answer 12

pomalidomide, BMS, IMiD

Question 13

Revlimid: INN, company, MoA

Answer 13

lenalidomide, BMS, IMiD

Question 14

zevor-cel: company, MoA and target

Answer 14

Cargsen, BCMA, CAR-T

Question 15

Pepaxti: INN, company, MoA

Answer 15

melflufen, oncopeptides, alkyliting agent

Question 16

Elranatamab: company, MoA and target

Answer 16

Pfizer, BCMA TCE

Question 17

Venclexta/Venclyxto: INN, company, MoA and target

Answer 17

venetoclax, Abecma, BCL2i (small molecule)

Question 18

Sarclisa: INN, company, MoA and target

Answer 18

isatuximab, Sanofi, CD38 mAb

Question 19

Darzalex: INN, company, MoA and target

Answer 19

daratumumab, JNJ, CD38 mAb

Question 20

Velcade: INN, company, MoA and target

Answer 20

bortezomib, Takeda, PI

Question 21

Ninlaro: INN, company, MoA and target

Answer 21

ixazomib, Takeda, PI

Question 22

Modakafusp alpha: company + target

Answer 22

Takeda + CD38

Question 23

Tecvayli: INN, company, MoA + Target

Answer 23

teclistamab, JNJ, BCMA TCE

Question 24

Nexpovio/Xpovio: INN, company + Target

Answer 24

selinexor, Karyopharm, XPOi (small molecule)

Question 25

Blenrep: INN, company, MoA + Target

Answer 25

belantamab mafadotin, GSK, BCMA ADC

Question 26

talquetamab: company, MoA + target

Answer 26

JNJ, GPRC5D, mAbs

Question 27

PHE885: company + target

Answer 27

Novartis + BCMA CAR-T

Question 28

What are Regeneron's BCMA TCE's?

Answer 28

RGN5458 and RGN5459

Question 29

alnuctamab: company, MoA and target

Answer 29

BMS, BCMA TCE

Question 30

What's the KarMMa-3 trial

Answer 30

Phase 3 trial of Abecma (ide-cel) vs. SoC in 3-5L RRMM

Question 31

What do the KarMMa trials evaluate (Drug name + INN)

Answer 31

Abecma (ide-cel)

Question 32

What do the DREAMM trials evaluate (Drug name + INN)

Answer 32

Blenrep (belantamab mafadotin)

Question 33

What do the MajesTEC-3 trials evaluate

Answer 33

teclistamab

Question 34

What do the MagnetisMM trials evaluate

Answer 34

elranatamab

Question 35

What do the MonumenTAL trials evaluate

Answer 35

talquetamab

Question 36

What do the TRIMM trials evaluate

Answer 36

talquetamab

Question 37

What does the PERSEUS trial evaluate

Answer 37

Phase 3, DVRd vs. VRd in TE NDMM

Question 38

What does the GRIFFIN trial evaluate

Answer 38

Phase 2, DVRd vs VRd in TE NDMM

Question 39

What do the PERSEUS and GRIFFIN trials evaluate

Answer 39

DVRd vs VRd in TE NDMM

Question 40

What's the difference between the PERSEUS and GRIFFIN trials

Answer 40

PERSEUS is Phase 3, GRIFFIN is Phase 2

Question 41

What does the ADVANCE trial evaluate

Answer 41

Phase 2, DKRd vs KRd

Question 42

What does the CEPHEUS trial evaluate

Answer 42

Phase 3, DKRd vs KRd

Question 43

What do the ADVANCE and CEPHEUS trials evaluate

Answer 43

DKRd vs KRd

Question 44

What's the difference between the ADVANCE and the CEPHEUS trials?

Answer 44

Advance is Phase 2, CEPHEUS is Phase 3

Question 45

What are the key quad trials

Answer 45

PERSEUS, GRIFFIN, ADVANCE, CEPHEUS , GMMG-HD7, ISKIA

Question 46

What do we want to know about the quad trials?

Answer 46

Timelines for readout

Question 47

What does the GMMGH7 trial study

Answer 47

IsaVRd vs VRd

Question 48

What does the ISKIA trial study

Answer 48

IsaKRd vs KRd

Question 49

Based on which trial was teclistamab FDA approved in October 2022

Answer 49

Phase 1/2 MajesTEC-1 trial in 4L+ RRMM

Question 50

In what line of therapy was teclistamab FDA approved? What type of approval was it

Answer 50

5L+ RRMM, accelerated approval

Question 51

What does the Phase 3 MajesTEC-9 trial evaluate? When was it posted?

Answer 51

Tec monotherapy vs. PVd or Kd in 2-4L RRMM; it was posted in October 2022

Question 52

Whats the earliest approval based on the MajesTEC-9 trial? In what

Answer 52

H1 2026, in 2L+ RRMM (tec monotherapy)

Question 53

What does the Phase 3 MajesTEC-3 trial evaluate?

Answer 53

Tec + Dara vs DPd or DVd in 2L+ RRMM

Question 54

What do the CAMMA trials evaluate?

Answer 54

cevostamab

Question 55

What's Roche's GPRC5D?

Answer 55

RG6234 (it was previously from Regeneron)

Question 56

RG6234: company, MoA

Answer 56

Roche, GPRC5D TCE

Question 57

What does the Phase 3 IMROZ trial evaluate

Answer 57

Sarlisa + VRd in TI NDMM

Question 58

What does the Phase 3 CANOVA trial evaluate

Answer 58

Ven _ d vs. Pd in 3L+ RRMM