Kidney/Gastro Flashcards

(56 cards)

1
Q

Chronic kid disease

A

prog loss of renal function persisting for more than 3 months

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2
Q

Chronic kidney disease cause

A

diabetes, htn, Chronic glomerulonephritis Polycystic kidney disease

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3
Q

Chronic kid disease Pathophysiology

A

Progressive destruction/deterioration of nephrons Hypertrophy of remaining nephrons to compensate Homeostasis preserved until >50% nephron destruction

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4
Q

Best measure of overall kidney function

A

GFR

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5
Q

in early kidney disease, patients are

A

asymptomatic - 50% nephron destruction before symptoms

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6
Q

Chronic kid disease progression

A

nitrogenous waste builds up in the blood, leading to symptoms.

Kidneys perform fewer excretory, endocrine, metabolic functions. This is where patients get their symptoms.

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7
Q

Chronic kid disease conservative care

A

decrease nitrogenous waste intake (diet), manage HTN, manage fluids, electrolytes, Na, K.

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8
Q

Stage 1 and Stage 2 has more

A

conservative care

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9
Q

—— and —— are two major contributing factors

A

HTN, Diabetes

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10
Q

Stage 3 treatment

A

More aggressive conservative care.

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11
Q

Dialysis for

A

some stage 4 (depends on how pt is doing, risk factors), all for stage 5.

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12
Q

Hemodialysis done every

A

2-3 days for 3-4 hours per session. In between sessions, life is pretty normal. Day after is the best day for dental tx.

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13
Q

—– injected during dialysis process

A

heparin.

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14
Q

20% of US patients on

A

peritoneal dialysis

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15
Q

—— surgically created in forearm for hemodialysis

A

AV fistula. DO NOT EVER USE IT.

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16
Q

Avoid/adjust dosage of nephrotoxic drugs and those excreted by the kidneys if GFR < —-

A

60

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17
Q

No BP cuff on arm with

A

AV shunt.

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18
Q

If AV shunt infected, it will likely be a

A

staph infection

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19
Q

Peptic ulcer disease is

A

chronic.

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20
Q

Most peptic ulcers tend to be in the

A

duodenum.

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21
Q

Most common cause of peptic ulcer disease

A

Heliobactor pylori

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22
Q

Heliobactor pylori hang out

A

where the gastric epithelium meets the overlying mucous.

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23
Q

H pylori produces a —– that hyrdrolyzes urea to ammonia and CO2

24
Q

H pylori - host inflammatory response to —- causes damage

25
NSAIDs | Topical irritant, decrease -------- production, inhibit ----- secretion, decrease mucosal --------
prostaglandin mucous blood flow
26
• 2nd most common cause of peptic ulcer disease
NSAIDS
27
NSAID ulcers more often in
stomach
28
If older than 60, long term (more than 1 month) NSAIDs, simultaneous use of alcohol, steroids, aspirin
patient is at increased risk to develop peptic ulcer disease.
29
Peritoneal perf
worst case scenario - now gastrointestinal bacteria in sterile peritoneum. Life threatening.
30
Healed ulcers can
fibrose.
31
Pyloric stenosis
delayed gastric emptying - due to fibrosis potentially.
32
Peptic ulcer disease symptoms
Empty stomach or 90min-3h after eating
33
Worsening ulcer can lead to
angina symptoms
34
Peptic ulcer patients are treated by
attacking acid.
35
If infected with H pylori
use antibiotics with proton pump inhibitor
36
For peptic ulcer dental patients, avoid
NSAIDs, aspirin
37
For patients with peptic ulcer disease and pain, you can prescribe
Prescribe: acetaminophen, acetaminophen combinations
38
Ulcerative colitis
Mucosa | Large intestine and rectum
39
Crohn’s disease
Full-thickness bowel wall | Can involved any portion of alimentary canal
40
UC crohns, causes
idiopathic, immune disfunction in genetically susceptible people.
41
UC characterized by
remissions and exacerbations.
42
UC predisopses to
colon carcinoma. - 10x more likely.
43
----% of UC patients relapse in a year
50
44
In crohns disease ----- of small bowell occurs
thickening and stenosis Resections can be done.
45
Crohns - ----- year delay in diagnosis
3 - due to difficulty and variability in presentation
46
1st line for UC/crohns
antidiarrheal, antiinflammatory (antiinflamatory specific for GI).
47
2nd line for UC/crohns
immunosuppressive agents and antibiotics
48
Corticosteroids to induce
remission in moderately- severely ill patients
49
UC crohns, Avoid ---- drugs | ------
anti-inflammatory, Ibuprofen
50
Caution with antibiotics (Clindamycin)-monitor for signs/ symptoms of ---------
pseudomembranous colitis
51
Sulfasalazine (an anti-inflammatory for IBD) can cause ------------
leukopenia & thrombocytopenia
52
If patient is given broad spectrum antibiotic, normal gut bacteria is wiped out, making it predisposed to
Pseudomembranous colitis. (C. difficile) -amox, clindamycin
53
P. colitis - Timing: within ----- of antibiotic administration
4-10d
54
PCP—Treat C. difficile infection
Oral metronidazole | Vancomycin
55
For P. colitis - ------- dental care until -------
Delay elective free of disease symptoms
56
C. dificile not likely after
single dose of antibiotic following IE prophylaxis.