Kidney Pathology Flashcards

1
Q

what location do the kidneys develop?

A

in the pelvis within the 5th week of development

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2
Q

at what week does the kidney ascend to the abdomen?

A

the kidney ascends into the abdomen by the 9th week of development

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3
Q

what are genitourinary tract anomalies?

A

Bicornuate uterus and seminal vesicle agenesis

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4
Q

what are the most common complications of renal anomalies?

A

impaired renal function, infection and calculus formation

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5
Q

renal agenesis is also called?

A

Potter’s syndrome

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6
Q

Bilateral renal agenesis is predominantly in what gender?

A

males; it is very rare

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7
Q

what are the sonographic signs of renal agenesis

A
  • kidney and bladder not visualized
  • low amniotic fluid
  • decreased movement and development
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8
Q

with unilateral renal agenesis, which kidney usually does not develop?

A

the left kidney

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9
Q

what is typically seen in an ultrasound of unilateral renal agenesis?

A
  • enlargement of contralateral kidney
  • 70% genital anomaly
  • bicornuate uterus
  • seminal vesicle agenesis
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10
Q

what is a supernumerary kidney?

A

where there is the presence of an extra kidney with its own blood supply and ureter

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11
Q

what is an ectopic kidney?

A

where one kidney fails to ascend from the pelvis to its proper location during development

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12
Q

typically, where is the ectopic kidney located?

A

in the pelvis as a palpable mass

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13
Q

Pelvic kidney is prone to…

A

poor drainage, ureteral reflux, and hydronephrosis

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14
Q

what is a dromedary hump?

A

a single hump of lobulation on the lateral border of the kidney

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15
Q

what is a horseshoe kidney?

A

a developmental anomaly that occurs when the kidneys fuse together, creating a horseshoe-shaped structure in the lower abdomen.

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16
Q

where does a horseshoe kidney usually occur?

A

across the midline, anterior to the aorta

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17
Q

what symptoms can occur with horseshoe kidney?

A

horseshoe kidney is asymptomatic, but increases the risk for complications such as infection, stones, obstruction, and hematuria

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18
Q

how does horseshoe kidney appear on ultrasound?

A

a palpable mass anterior to the aorta

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19
Q

what is a hypoplastic kidney?

A

a hypoplastic kidney is a congenitally small kidney that may be normal or often incompletely developed

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20
Q

what is a duplex kidney?

A

where the developing kidney is divided into upper and lower sections. the lower section is usually larger

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21
Q

what is the most common renal anomaly?

A

double collecting system/ duplex kidney

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22
Q

define complete double collecting system

A

two collecting systems and two ureters that both enter the bladder

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23
Q

define incomplete double collecting system

A

two collecting systems and two ureters that unite distally before entering the bladder

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24
Q

which part of the kidney typically has problems?

A

the upper section of the kidney usually shows signs of hydronephrosis

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25
Q

which disease processes are associated with duplex kidney?

A

obstruction and reflux

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26
Q

duplex kidney is associated with ____ in females?

A

uterus didelphys (double uterus)

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27
Q

how does duplex kidney appear on ultrasound?

A

the duplex kidney is usually enlarged, and the renal sinus appears as two echogenic regions separated by normal renal tissue

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28
Q

how do you check for two ureters?

A

you check for two ureters by seeing if there are two ureters exiting the hilum of the kidney

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29
Q

what is an extrarenal pelvis?

A

an extrarenal pelvis is a renal pelvis that lies outside the renal sinus

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30
Q

how does an extrarenal pelvis appear on an ultrasound?

A

it appears as a cystic collection medial to the renal hilum

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31
Q

define ARPKD

A

Autosomal Recessive Polycystic Kidney Disease. this is found in infants and causes a dilation of the renal collecting tubules in the renal cortex. it is life- threatening.

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32
Q

what is the risk factor for a recessive gene?

A

it can be very likely to occur if both parents carry the gene for the disease.

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33
Q

what does ARPKD look like on ultrasound?

A

the cysts are too small to be seen on ultrasound. The kidney appears echogenic.

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34
Q

what is the survival rate of ARPKD?

A

survival rate is very low, most do not survive for very long.

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35
Q

what is ADPKD?

A

autosomal dominant polycystic kidney disease

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36
Q

what is the survival rate for a patient with ADPKD?

A

the survival rate is very high, but 50% of patients develop renal failure by 50 yoa

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37
Q

when do symptoms of ADPKD occur?

A

by the age of 50

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38
Q

what are the clinical signs of ADPKD?

A

infection, stones, or cystic rupture

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39
Q

how does ADPKD (PKD) appear on ultrasound?

A

multiple irregular cysts that consume the kidney’s tissue. the kidneys can also become enlarged. ADPKD can also be associated with liver, pancreas, and splenic cysts

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40
Q

Medullary cystic disease is a _____ gene.

A

dominant

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41
Q

where are medullary cysts located?

A

in the medulla of the kidney

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42
Q

what is the sonographic appearance of medullary cystic disease?

A

small echo-dense kidneys due to numerous small cysts under 2cm

43
Q

multicystic dysplastic kidney disease is ______

A

nonhereditary

44
Q

what is the most common cystic pathology of the kidney?

A

multicystic dysplastic kidney is the most common pathology of the kidney in neonates

45
Q

what are the symptoms for multicystic dysplastic kidney?

A

mostly asymptomatic, but can cause polyuria, hypertension, infection, etc.

46
Q

what are the sonographic signs for multicystic dysplastic kidney disease?

A

numerous visible cysts under 1cm within the renal parenchyma

47
Q

define acquired cystic dysplasia

A

acquired cystic dysplasia is renal cysts that are acquired over time.

48
Q

when does acquired cystic dysplasia occur?

A

typically, acquired cystic dysplasia will occur when a patient undergoes dialysis

49
Q

what is medullary sponge kidney?

A

a nonhereditary disease where there is cystic dysplastic dilation of te collecting tubules (papillary necrosis)

50
Q

medullary sponge kidney is associated with what disease?

A

Caroli’s disease

51
Q

what is the sonographic appearance of medullary sponge kidney?

A

the medullary pyramids appear echogenic and sponge-like

52
Q

what do 80% of medullary sponge kidney patients have by the age of 40?

A

tubular ectasia and calcium stones

53
Q

what is pyelonephritis

A

an upper UTI

54
Q

what age group does pyelonephritis affect?

A

women in early child-bearing age

55
Q

what are the clinical symptoms for pyelonephritis?

A

fever, flank pain, frequency, hematuria, and dysuria.

56
Q

what does a kidney with an infection look like on utrasound?

A

it can look enlarged

57
Q

acute renal failure is caused by…

A

decreased renal function, usually caused by acute tubular necrosis

58
Q

what are the clinical symptoms for acute renal failure?

A

elevated creatine, hematuria, hypertension, sepsis, and severe dehydration

59
Q

what is the sonographic appearance of acute renal failure?

A

normal or elarged kidney, hydronephrosis, and an abnormal resistive index (RI)

60
Q

define chronic renal failure

A

chronic renal failure develops over a long period of time where there is a decreased amount of renal function

61
Q

what are the clinical symptoms of chronic renal failure?

A

anemia, headaches, hypertension, weight loss, N/V, pruritis, polyuria, nocturia, and chronic UTIs

62
Q

what is the sonographic appearance of chronic renal failure?

A

chronic renal failure appears as a small kidney with a loss of cortical (cortex) thickness <2cm, and a hyperechoic cortex (loss of normal anatomy)

63
Q

list the pre-existing conditions for renal failure

A
  • hypertension
  • hypotension
  • CHF
64
Q

what are the renal causes for renal failure?

A
  • infection
  • nephrotoxicity
  • renal artery occlusion
  • renal mass or cyst
65
Q

what are other causes of renal failure?

A
  • lower urinary tract obstruction
  • retroperitoneal obstruction
66
Q

what are the 3 types of chronic renal failure?

A
  • nephron
  • vascular
  • interstitial
67
Q

how common are renal cysts?

A

50% of the population over 50 have renal cysts

68
Q

what are the two types of renal cysts

A

cortical and peripelvic cysts

69
Q

where are perapelvic cysts located?

A

located in the hilum but do not project into the renal pelvis

70
Q

what are the medical terms for kidney stones?

A

nephrolithiasis, renal calculi, and nephrocalcinosis

71
Q

what are kidney stones made of?

A

calcium or uric acid

72
Q

what might cause kidney stones?

A

change in pH or uric acid, hereditary, bacteria, or high calcium levels

73
Q

who is commonly affected by kidney stones?

A

white men from the age of 20-50

74
Q

what are the clinical symptoms of kidney stones?

A

hematuria, oliguria, flank pain, and pyuria

75
Q

what is the sonographic appearance of kidney stones?

A

kidney stones appear as echogenic foci with strong shadow posterior to the stone

76
Q

what is hydronephrosis?

A

where the renal pelvis and calyces become dilated due to obstructed outflow of urine

77
Q

what are some common causes of hydronephrosis?

A

stones, prostate hypertrophy, prostate CA, or pelvic malignancy

78
Q

what percentage of women present with hydronephrosis?

A

65% to 85%

79
Q

what is mild or grade 1 for hydronephrosis?

A

slight separation of the collecting system

80
Q

what is moderate or grade 2 for hydronephrosis?

A

dilation of some but not all calyces

81
Q

what is severe or grade 3 for hydronephrosis?

A

dilation of all calyces

82
Q

what is severe or grade 4 for hydronephrosis?

A

prominent dilation or thinning cortex

83
Q

where is a transplanted kidney placed?

A

in the pelvis/ iliac fossa

84
Q

in a transplant, where is the renal artery relocated?

A

the common iliac artery

85
Q

what are the clinical signs of a transplant rejection?

A

fever, pain, decreased output, and elevated creatine levels

86
Q

what are the sonographic signs of rejection?

A

fluid, swollen with loss of internal structures, hydronephrosis, etc.

87
Q

what is the most correctable cause of hypertension?

A

renal artery stenosis

88
Q

what is the most common cause of renal artery stenosis?

A

ateriosclerosis

89
Q

what are the clinical signs of renal artery stenosis?

A

rapid onset of hypertension, elevated BUN, elevated creatine, and flank pain

90
Q

what are the doppler signs of renal stenosis?

A

RI = >.7
RAR (renal artery ratio) is 3.5x greater than that of the aorta.
tardus parvus waveform may be present with stones

91
Q

when you have decreased blood flow to the kidneys, the kidney will be ____

A

enlarged

92
Q

what is the most common cause of renal failure?

A

acute tubular necrosis (ATN)

93
Q

what are the causes of ATN?

A

surgery, sepsis, hypotenstion, pregnancy complication, obstetric jaundice

94
Q

what is the sonographic appearance of ATN?

A

bilateral enlarged kidney and increased RI

95
Q

renal vein thrombosis is most common in _____

A

children

96
Q

renal vein thrombosis is associated with ______

A

trauma or tumor

97
Q

what are the clinical symptoms of renal thrombosis?

A

massive proteinuria, epigastric pain, hematuria, and dehydration

98
Q

what are the sonographic signs of renal thrombus?

A
  • size increase in acute phase and cortex decreases
  • later stages-kidney decreases
  • enlarged renal vein with no flow
  • renal artery will have retrograde and diastolic flow
99
Q

what is artery occlusion?

A

the absence of blood flow in the main renal artery

100
Q

what are the clinical symptoms of renal artery occlusion?

A

sudden hypertension, flank pain, elevated BUN, and elevated creatine

101
Q

what is the sonographic appearance of renal artery occlusion?

A

small kidney that is less than 1.5cm shorter than the other

102
Q

what is a renal infarction?

A

where part of the renal tissue undergoes necrosis from an arterial occlusion

103
Q

what are the causes of a renal infarction?

A

thrombosis, tumor, or occlusion

104
Q

what is the sonographic appearance of a renal infarction?

A

renal infarction appears as a triangular, echogenic mass in the renal parenchyma