Kidneys Flashcards

(134 cards)

0
Q

What is the anatomical location of kidneys?

A

Retroperitoneal

Flank area

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1
Q

Renal Embryology

A

Kidneys usually develop by 15 weeks gest age in pelvis and then ascend to lumbar region.
Migration is not complete until 5-6 years old

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2
Q

Which muscles are posterior to the kidneys?

A

Psoas muscle, and Quadrates Lumbordum muscles.

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3
Q

What covers the kidneys?

A

Gerota’s Fascia

Which also covers the peritoneal fat, renal capsule and adrenal glands

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4
Q

What is the normal adult kidney measurement?

A

9-12 cm in length
4-6 cm in diameter
2.5-4 cm in depth (AP)

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5
Q

Neonatal kidney measurements?

A

3.5-5 cm in length
2-3 cm in diameter
1.5-2.5 cm in depth

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6
Q

What are the 3 distinct regions of the renal parenchyma?

A

Cortex, medulla (medullary pyramids) and renal pelvis

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7
Q

What is the pathway of urine through the collecting system?

A

Urinary sinus- minor calyces- major calyces- renal pelvis- ureter- bladder

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8
Q

What is the echogenicity of a normal kidney?

A

Renal cortex is homogenous and either isoechoic or hypoechoic to liver or spleen
Medullary pyramids are usually hypoechoic to anechoic in appearance.
Collecting system/ sinus appears highly echogenic due to fat and only becomes hypoechoic or anechoic when there is blockage

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9
Q

What is the anatomical relationship of the renal artery in respect to the IVC?

A

Right renal artery passes posterior to IVC

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10
Q

What is the anatomical relationship of the renal veins?

A

Right renal vein is shorter than left
Left renal vein courses anterior to aorta but posterior to SMA

*renal veins are inferior to renal arteries

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11
Q

What does the renal arterial vasculature consist of?

A

Renal artery, segmental artery, interlobar artery, arcuate artery, interlobular artery

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12
Q

What is the pathway of blood through the kidney?

A

Segmental arteries- interlobar a.- arcuate a.- interlobular a.- afferent arteriole- glomerular filtration- efferent arteriole- peritubular capillaries- interlobular v.- arcuate v.- interlobar v.- renal v.- IVC

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13
Q

What is the functional unit of the kidney?

A

Nephron

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14
Q

What is the excretory function of the kidney?

A

Removal of waste from blood by the glomerulus

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15
Q

What is the regulatory function of the kidney?

A

Balances fluid and electrolyte contents of blood through re-absorption and secretion by the renal tubules

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16
Q

Which components of blood are too large to pass through the nephron’s membrane?

A

Blood cells such as RBC, WBC, Platelets, and plasma proteins such as albumin and globulin.

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17
Q

What is Aldosterone?

A

Hormone secreted by adrenal glands.
Increases tubule permeability to increase reabsorption of sodium.
Adjusts fluid uptake in the event of dehydration and hemorrhage

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18
Q

Which is the most specific indicating lab function test for kidney dysfunction?

A

Serum Creatinine

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19
Q

What other lab function test are there for renal evaluation?

A

BUN- also rises with renal dysfunction

Uric Acid level- increases with renal failure and causes gout

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20
Q

Why do RBC increase when renal dysfunction is present?

A

Kidney secretes erythropoietin to stimulate RBC production from bone marrow in the presence of hypernephroma, RCC and renal cysts

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21
Q

What is the most common anomaly of the genitourinary tract?

A

Duplicate collecting system
1 in 157 adults
Most common in women

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22
Q

What types of duplicate collecting systems are there?

A

Incomplete: 2 pelvis, 1 ureter
Complete: 2 pelvis, 2 ureter * may become obstructed due to ureterocele

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23
Q

What is the sonographic appearance of duplicate collecting system?

A

Complete separation of normal renal sinus echodensities
Cause of isolated hydronephrosis
Can mimic cyst but cyst usually in cortex

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24
What is prominent or hypertrophic column of Bertin?
Considered a variant Double thickness of cortical tissue between 2 pyramids can create or mimic a pseudocyst
25
Sonographic findings with column of Bertin
Renal sinus is clearly defined Largest dimension is less than 3 cm It is continuous or contiguous with the renal cortex Echogenicity is close to that of the cortex
26
What is Dromedary Hump?
A variant Bulging of the mid section of left kidney Same echogenicity as cortex
27
What is horseshoe kidney?
Anomaly Lower pole of kidneys are fused at the midline of body 1 in 400 IVP and CT are good for identification of horseshoe kidney in adjunct to ultrasound
28
What Is pelvic kidney?
Anomaly Non-visualization of a kidney in renal fossa Ectopic kidney. Failed to ascend to upper quadrant. Note: transplanted kidneys are in the pelvis
29
What is Renal Agenesis?
Anomaly No kidney formation. Will have unilateral large kidney due to contra-lateral compensation
30
What is another name for Junctional Parenchymal Defect?
Fetal Lobation Typically occurs on the anterior surface of the upper pole of kidney
31
What is Supernumerary Kidney?
Anomaly Very rare Complete duplication of kidney Extra kidney with its own blood supply. Usually ectopically placed and shares ureter
32
What is crossed renal ectopia?
When a kidney ascends to the contralateral side. You will see 2 kidneys on one side of abdomen and none on the other One ureter crosses midline to enter other side of bladder
33
What is crossed fused renal ectopia?
Unilateral fused kidney The developing kidneys fuse while in the pelvis and one kidney ascends to its normal position, carrying the other one with it across the midline
34
What is extrarenal pelvis?
An extra renal pelvis that lies outside the renal sinus. | Sonographically appears as a cystic collection medial to the renal hilum
35
What is posterior urethral valve?
``` Common cause of urinary obstruction in a male infant due to a flap of mucosa that has a slit-like opening in the opening of the area of the prostatic urethra. You will see a large bladder Hydroureter Hydronephrosis Possible urinoma ```
36
What is Renal Sinus Lipomatosis?
Excessive fatty infiltration of the renal pelvis associated with obesity, or Parenchymal atrophy
37
What are the indications for a Renal Ultrasound?
``` Hematuria Oligouria (scanty urine) Flank pain Increased serum creatinine Palpable mass in lumbar region Chronic UTI Obstruction of the GU tract such as nephrolithiasis ```
38
How does renal infection develop?
Secondary to respiratory infection, its prevalence can cause mortality. Usually originates from bladder and spreads to kidneys. E-colimis the most common bacteria responsible for 85% UTI Women are more susceptible due to shorter urethra. Urinary stasis from voiding interference enhances bacterial growth (pregnancy, urolithiasis, benign prostatic hypertrophy- BPH)
39
Where can renal infection originate from?
Urethra, lymphatics, vascular. | Skin, bone and heart infections can disseminate to the nephron's via blood
40
Who is more susceptible to renal infection and why?
Women due to shorter urethra Women with increased sexual activity Pregnancy due to increased pressure on bladder and ureters
41
What is Acute Pyelonephritis (APN), and what is its etiology?
Sudden Renal Plevis inflammation Abrupt onset. Usually caused by gram-negative bacilli from intestinal tract Causes suppuration (puss) Unilateral or bilat Focal or diffused infection Can lead to micro abcess formations in kidney Associated with UTI
42
What are the clinical findings of APN?
``` Flank pain Fever and chills Urinary frequency Elevated WBC Dysuria (painful/difficult urination) Pyuria (puss in urine) ```
43
What are the sonographic findings of APN?
Kidneys may have normal appearance in early stages. | As infection progresses, the kidneys may show abnormal echopatterns (focal or diffused)
44
What is the focal appearance of APN?
Enlarged, hypoechoic kidney with absence of sinus echoes
45
What is the diffused appearance of APN?
Enlarged echogenic kidney due to multiple abscess Cortex also becomes echogenic if there is abscess formation The sinus will blend with the parenchyma
46
What is Acute Focal Bacterial Nephritis?
Focal wedge-shaped area or a hypoechoic renal lobe without renal enlargement
47
What is Emphysematous Pyelonephritis?
Emphysema- presence of air on tissue Intrarenal gas accumulates causing a dirty ringdown reverberation artifact Common in diabetes, immune-suppressed patients and those with UTI
48
What is Chronic Pyelonephritis (CPN) | And what causes it?
A silent, insidious, progressive disorder From recurrent infections like UTI, obstructive lesions or vesico-ureteral reflux Inflammation leads to scarring which can contribute to tubular dysfunction and parenchymal atrophy.
49
What is the clinical presentation of CPN?
``` Flank pain Oliguria HTN Foul smelling urine Slight increase in WBC Mild fever and chills Proteinuria (urine will be smoky) ```
50
What are the lab findings for CPN?
Poor renal function (decreased GFR) Proteinuria Increased blood creatinine Increased BUN
51
What are the sonographic findings of CPN?
Kidneys will atrophy as the disease progresses (<8 cm) Increased parenchymal echoes due to fibrosis Echogenic Zone extends beyond normal areas of the sinus
52
What are other names for Renal Abscess?
Carbuncle | Perinephric Abscess
53
How does a Carbuncle occur?
Bacterial infections such as staph. Aureus or Gram Negative Bacilli spread to kidneys via blood or the ascending route from bladder. Abscess results in flank pain, Fever and chills
54
What are the sonographic findings of a renal abscess?
``` Echogenic Renal mass Thick wall Irregular margins Reverberation or shadow artifact from gas-producing organisms Septations Possible acoustic enhancement ```
55
What is Xanthogranulomatous Pyelonephritis?
Due to chronic infection and obstruction of the uretero-pelvic junction from a staghorn calculus (blocking renal pelvis)
56
What will you find with Xanthogranulomatous pyelonephritis?
``` Renal enlargement Parenchymal abcess Staghorn calculus Papillary necrosis Possible hydronephrosis ```
57
What is Pyonephrosis?
Purple to material in the collecting system Associated with renal obstruction Percutaneous or surgical drainage is required Echogenic debris in a dilated renal collecting system is seen on ultrasound
58
Etiology of Acute and Chronic Glomerulonephritis?
An antigen-antibody inflammatory response (autoimmune reaction) in the glomerulus, secondary to streptococcal infection Leads to increased peritubular capillary permeability and cell proliferation resulting in leakage of proteins and RBC into the filtrate (ends up in tubules which congest area and slow down filtration process Decreases GFR Fluid and waste retention occurs, leading to ARF if prolonged Chronic conditions can lead to CRF
59
What is the clinical presentation of Glomerulonephritis?
Flank pain Hematuria Edema (beginning at face) HTN leading to headache, nausea, fatigue and stroke
60
What are the lab findings of Glomerulonephritis?
Increased creatinine Increased BUN Azotemia (abnormally high levels of nitrogen-containing compounds in the blood such as urea, creatinine) RBC in urine
61
What are the sonographic findings of Glomerulonephritis?
Enlarged Echogenic kidney Cortex will have equal echogenicity to sinus followed by increased cortical echogenicity Post treatment of primary streptococcal infection will return the kidney's size and echogenicity back to normal
62
What causes ARF?
``` Prinmary cause is Acute Tubular Necrosis (ATN) Decreased GFR Acute Glomerulonephritis Prolonged circulatory shock or trauma Septicemia Burns Interstitial nephritis Urinary tract obstruction Bilat renal artery occlusion or DVT Heart failure and Hypotension Tumors ```
63
What are the 2 phases of ARF?
Oliguria: Decreased urine output Tissue breakdown Diuretic phase: Few days to 6 weeks after onset Increased urine output Indicates nephron recovery
64
What are the clinical findings of ARF?
``` Oliguria Hypertension Muscle fatigue GI bleed Infections ```
65
What are the sonographic findings of ARF?
May be normal in early stages Kidneys may also enlarge bilat Homogenous echogenic pattern Increased RI with hypoperfusion
66
What is the etiology of CRF?
``` Decrease in GFR Hypotension Diseases such as: AGN (acute glomerulonephritis) CPN (chronic pyelonephritis) Renal vascular disease Diabetes Toxins Polycystic disease ```
67
Clinical presentation of CRF
``` Early stage: Polyuria Nausea HTN Increased BUN & Creatinine Later stage: Oliguria Dry skin Impotence Encephalopathy CHF ```
68
What is the sonographic appearance of CRF?
Small, shrunken, echogenic kidney which is definitive of end stage renal failure Kidney measures < 8 cm in length Cortical thinning < 1 cm
69
What is Mycetoma?
Fungal ball Candidiasis is another name Most common renal fungal disease as a result from hematogenous seeding or ascend from bladder Usually seen in immune suppressed patients such as AIDS fungal balls appear as hyperechoic, non shadowing masses
70
When performing renal biopsy where should the needle be directed?
Lateral aspect of lower pole | 10 degree cephalad angulation
71
What is the RI used for and what is its formula?
Used to evaluate renal transplants, access suspected hydronephrosis, medical renal disease and suspected renal neoplasm RI= PSV-EDV/PSV
72
Where is a simple renal cyst found?
``` Commonly encountered in patients over 40 years old Found in 50% of patients over 50 Origin is usually unknown Serous fluid filled Usually solitary ```
73
What are the sonographic findings of a simple cyst?
Normal characteristics of a simple cyst Range in size 98% accuracy with ultrasound Mural growth may indicate malignancy
74
What types of simple cysts are there?
``` Cortical/single Cortical/multiple Pyelogenic cyst Parapelvic Peripelvic ```
75
Where does a pyelogenic cyst arise from?
Renal pelvis, infundibulum or calyces (calyceal diverticulum) Show appearance of a simple cyst in ultrasound
76
What is a parapelvic cyst?
Cysts that bulge into the central sinus of the kidney which may cause symptoms and can be mistaken for hydronephrosis
77
What is a Peripelvic cyst?
Lymphatic cysts in the central sinus. Identical ultrasound appearance of parapelvic cysts
78
Note on renal cysts
Cortical cysts: originate from uriniferous tubules Pyelogenic cysts: calyceal diverticula Parapelvic cysts: parenchymal cysts Peripelvic cysts: lymphatic cysts
79
Are hemorrhagic cysts associated with neoplasm?
Yes 31% | They can also be associated with trauma
80
Clinical symptoms of hemorrhagic cyst
Abdominal pain Back and flank pain Hematuria
81
What is MOC (Milk of Calcium)
Low grade inflammation and partial or complete blockage of a calyceal diverticulum Quite common and represents calcium carbonate crystals
82
Sonographic appearance of MOC
Anechoic area near calyx Echogenic mobile foci or gravity dependent wall Acoustic shadowing
83
What is Medullary Sponge Kidney?
``` Congenital autosomal recessive defect Common/innocuous Localized to medullary collecting ducts Dysplastic cystic dilation of pyramids Bilateral, multiple cystic dilation Occurs in adults ```
84
What are complications of Medullary Sponge Kidney?
Calcifications in dilated cysts Infection Urinary calculi
85
Sonographic appearance of Medullary Sponge Kidney
Hyperechoic medullary pyramids bilaterally Ectastatic collecting tubules No shadowing
86
Acquired cystic disease
Patients on chronic hemodialysis develop bilat renal cysts Hemorrhage often occurs into acquired cysts, resulting in pain, Hematuria and echogenic collections of cysts Higher incidence of renal cell carcinoma
87
What is Tuberous Sclerosis?
Multi-systemic disorder associated with renal cyst formation and multiple angiomyolipomas (sebaceous cysts) Patients present clinically with mental retardation, seizure and cutaneous lesions
88
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
``` Cause is unknown Inherited Autosomal Dominant defect Potter III disease Latent until 3-4th decade Bilat disease Cystic origin: convulated tubules, bowman's capsule Incidence: 1-1000-2000 Leads to renal failure and requires transplant ```
89
Clinical findings of ADPKD
Flank pain Back pain HTN Hematuria
90
Lab findings of ADPKD
Increased BUN Increased creatinine Hematuria Proteinuria
91
Complications of ADPKD
Destruction of residual tissue Advanced stages lead to renal failure and HTN Associated with Berry's Aneurysm: cerebral arterial/circle of Willis
92
What is the treatment for ADPKD?
Transplant
93
Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Unknown cause Theory states dilation of collecting tubules due to hyperplasia of interstitial portions Inherited Autosomal Recessive defect Potter I Common in infants Bilateral kidney involvement Associated with renal dysfunction and hepatic fibrosis
94
Clinical findings of ARPKD
Oligohydramnios in utero | Cannot produce urine due to a,punt of cysts
95
Ultrasound appearance of ARPKD
BEEK: Bilateral, Echogenic, Enlarged Kidneys Absence of renal parenchyma Abscess of renal sinus
96
Multicystic Dysplastic Kidney
Cause by atresia of uretero-pelvic junction during fetal development Most common cause of abdominal mass in newborn It can be unilateral or bilat Bilateral case can be fatal within 24 hrs of delivery Potter II
97
Clinical findings of MDK
Oliguria | Anuria if bilat
98
Sonographic appearance of MDK
Cysts of varying shapes and size Absence of communication between cysts Absence of renal sinus and parenchyma Renal architecture is gone
99
Renal Adenoma etiology
``` Most prevalent benign renal tumor From tubular epithelium Can only be distinguished from malignancy by histology Treated as malignant 3:1 ratio male over female Occurs usually in 6-7th decade ```
100
Clinical presentation of Renal Adenoma
Painless Hematuria
101
Ultrasound appearance of renal Adenoma
``` Similar to RCC Variable echogenicity Highly vascular May have internal echoes 1 cm in size mostly Rarely >3 cm ```
102
Angiomyolipomas (Renal Hematoma)
Fat, blood vessels and smooth muscle Cortical lesions More common in women 40-60 years old
103
Clinical findings of angiomyolipomas
May be asymptomatic May have flank pain Hematuria HTN
104
Sonographic appearance of angiomyolipomas
Echogenicity is greater than or equal to renal sinus fat Solitary Posterior displacement of structures behind these masses may be seen as a result of the slower acoustic velocity in these fatty Tumors (propagation speed artifact) Multiple associated with tubular sclerosis
105
Other names for Renal Cell Carcinoma
Hypernephroma
106
Etiology of RCC
``` Most common solid renal mass in adult 80-85% of adult renal tumor Unilateral Most common in men and African American 5-7th decade ```
107
Clinical findings of RCC
Pain Hematuria Palpable mass
108
Sonographic appearance of RCC
Unilateral, encapsulated solid mass Hyperechoic in cortex relative to adjacent normal tissue Multilocular cyst and hemorrhagic components may be present due to necrosis and hemorrhage Calcifications are common METS to liver, lymph nodes, adrenals and contralateral kidney
109
Stages of RCC
1: inside kidney 2: outside of kidney 3: goes to IVC 4: goes to lymph nodes and other organs
110
What is the treatment for RCC?
Nephrectomy
111
Associated findings with RCC
``` Von Hipple-Lindau syndrome Acquired cystic kidney disease ADPKD Tuberous Sclerosis Other syndromes associated with multiple cysts in kidneys ```
112
When RCC suspected, what other areas should be investigated?
``` Ipsilateral renal vein IVC Contralateral kidney and renal vein Retroperitoneum Liver for METS ```
113
Transitional Cell Carcinoma
Over 90% of TCC malignancies involve the renal pelvis and ureter Majority of TCC arises in the bladder Avg age diagnosis 61 yrs old
114
Clinical findings of TCC
Painless Hematuria Hydronephrosis Central filling defect on excretory urogram
115
Sonographic findings of TCC
Irregular hypoechoic mass in the renal sinus Usually too small for US detection Clot or fungal ball pattern Hypoechoic to isoechoic collecting system mass Secondary calyectasis Multiple and bilat
116
Are papillomas bening but have high risk of developing to to TCC?
Yes
117
Renal lymphoma
Non-Hodgkin lymphoma is the most common type | Bilat enlarged hypoechoic renal masses
118
What is Wilm's tumor?
``` Nephroblastoma Most common tumor in babies Malignant Arising from immature renal cells Less than 3 years old Large asymptomatic mass Mets is common to lungs, liver, bones, lymph nodes, adrenals and retroperitoneum IVC and renal veins should be evaluated for tumor extension Must be differentiated from adrenal neuroblastomas ```
119
Other names for kidney stones
Nephrolithiasis Urolithiasis Calculi
120
What causes nephrolithiasis?
Hot climates that promote dehydration, leading to concentrated urine and increases isolated precipitates of dissolved salts such as calcium oxylate, calcium phosphate
121
Risk factors for urolithiasis
``` Hereditary Renal dysfunction Bacteria Calyceal scarring Calyceal obstruction of collecting system Urine stasis ```
122
Clinical features of renal stones
``` Hematuria Oliguria Renal colic Nausea Vomiting Fever Pyuria Anuria Abdominal distention ```
123
Sonographic appearance of renal calculi
Echogenic foci Posterior acoustic shadowing Possible hydronephrosis Hydroureter
124
What is nephrocalcinosis?
Calcifications of the kidney
125
What kind of nephrocalcinosis are there?
Cortical nephrocalcinosis and | Medullary nephrocalcinosis
126
Cortical Nephrocalcinosis Predispositions?
``` Hyperparathyroidism Vitamin D intoxication Chronic glomerulonephritis AIDS Malignancies Acute cortical necrosis ```
127
What is pelvocaliectasis?
Non-obstructive dilation of the collecting system
128
Where should RI be?
0.7
129
Grades of hydronephrosis
``` Grade 1 Mild hydro Dilated renal pelvis Grade 2 Moderate hydro Dilated calyces Grade 3 Severe hydro Dilated pelvis, calyces and cortical thinning or loss of renal parenchyma ```
130
What causes ureteric obstruction?
``` Pregnancy Fibroids Bening prostatic hypertrophy BPH Tumors Mass effect ```
131
What is Ureteropelvic Junction (UPJ) obstruction?
Common congenital anomaly. | Associated with a contralateral multicystic Dysplastic kidney
132
Where is the most common site of renal obstruction in an adult?
Ureterovesicle junction (ureter/bladder junction)
133
What causes UVJ obstruction?
Renal calculi Pelvic tumors Trauma Infection