KNOW

Question 1

NK

Answer 1

antiviral, antitumor

Question 2

first innate to react

Answer 2

macrophage

Question 3

is a macrophage tissue resident

Answer 3

yes

Question 4

what do NK cells secrete

Answer 4

perforins and granzymes

Question 5

endosomal PRR

Answer 5

TLR

Question 6

cytosolic PRR

Answer 6

RIG1, NOD

Question 7

cell surface receptors

Answer 7

TLR (some), lectin

Question 8

macrophages secrete what and what do they do

Answer 8

IL-1B: increases vascular permeability, induces fever
TNFa: (same as IL-1B)
IL-6: induces release of acute-phase proteins, induces fever
CXCL8: recruit neutrophils (CHEMOKINE)

Question 9

rolling adhesion by

Answer 9

selectins bind carbs (sialyl groups)

Question 10

tight binding by

Answer 10

integrins (LFA1) on neutrofill and binding from iCAM (on endothelial surface)

Question 11

affected dendritic cell has

Answer 11

B7, binds to CD28

Question 12

instead of the interferons that kill, its the

Answer 12

perforin and granzymes

Question 13

after taking up virus, interferons

Answer 13

transcription and translation, TFa and beta

Question 14

how many hypervariable regions on one antibody

Answer 14

12

Question 15

where does maturation occur

Answer 15

primary/central lymphoid organs (thymus, bone marrow)

Question 16

where is antigen presented by dendritic cells to T cells

Answer 16

peripheral lymphoid organs (spleen, lymph node, tonsils)

Question 17

VDJ what recombines first

Answer 17

D and J first, V joins

Question 18

RAG1 and RAG2

Answer 18

make breaks at RSS coding regions, makes coding joint

Question 19

artemis

Answer 19

opens hairpin

Question 20

KU70/KU80

Answer 20

recruit DNA-PK

Question 21

tDt

Answer 21

add N-nucleotides, generates junctional diversity

Question 22

MHC I

Question 23

T cell- co stim and inhib

Answer 23

CD28 and B7 = co-stim
CTLA4 and B7 = inhib

Question 24

Immunological synapse TCR

Answer 24

MHC peptide complex, TCR< core rec, CD3 (iTAMs), post sitm molecules (B7, CD28)

Question 25

enzymatic steps in VDJ recombination

Answer 25

1. synapsis 2. cleavage 3. hairpin opening and end processing 4. joining

Question 26

Junctional diversity

Answer 26

N and P nucleotides

Question 27

TCR not expressed without

Answer 27

CD3