L 35 Androgen & Estrogen Flashcards
(23 cards)
What drugs are therapeutic Estrogens?
Estradiol
Ethinyl- Estradiol
Estrone
Therapeutic Estrogens indications?
1 hypogonadism
postmenopausal
oral contraceptive
fertility
suppress ovulation = pt w/ intractable dysmenorrhea, hirustium
What is commonly used as oral contraceptives?
Ethinyal-estradiol
Main estrogen in premenopausal
Estradiol
Natural estrogen of conjugated estrogens
Estrone
Therapeutic Estrogens SE?
Nausea
Fluid Retention
Bleeding
Menstrual Flow change
Breast tender
Therapeutic Estrogen Contraindications?
pregnancy
incomplete bone
genital bleeding
stroke
thrombophlebitis
thromboembolitic
heart disease
Therapeutic Estrogen interactions?
St Johns Wort = loss of contraceptive or hormonal replacement
Letrozole MOA?
(-) Estrogen Synthesis
(-) Aromatase
Letrozole uses?
2nd line tx breast cancer when tamoxifen doesn’t work
Take Letrozole with?
drugs to prevent bone loss
What drugs are Anti- Estrogens?
Clomiphene
Fulvestrant
Clomiphene MOA?
weak agonist & strong antagonist for ER-a or ER-b
oppose (-) feed of endogenous estrogen
Inc LH & FSH
Clomiphene uses?
induce ovulation in ppl w/ intact HPO axis
Clomiphene SE?
multiple births
ovarian cysts
Fulvestrant MOA? Tx?
pure estrogen antagonist
tx tamoxifen resistant tumor
What drugs are hormone replacement therapy?
Ethinyl estridol
Mestranol
Menopause S/S?
hot flash
sleep change
emotional change
headache
heart palpitations
generalized itching
What drugs are Synthetic Progestins?
Norethindrone
Norethindrone acetate
norgestrel
norgestimate
levonorgestrel
medroxyprogesteerone
Mifepristone MOA? Use?
antagonize progesterone
1st tri to terminate pregnancy
What drug is extended regimen contraception?
levonorgestrel/ ethanol estradiol
Emergency contraceptives drugs?
levonorgestrel
levonorgestrel + ethinyl estridol
Adult Male Hypogonadism Tx?
Transdermal testestrone esters
