L 6

Question 1

Osteoinduction

Answer 1

Mesnechymal osteoprogentior cells within graft area differentiated into OSB to form bone

Question 2

Bone matrix

Answer 2

bone matrix–>bone inductive proteins–> host cells–> OSB

Question 3

BMP Bone morphogenic protein

Answer 3

Initiates osteoinduction
BMP2 and 7 only commercially available

higher cortical vs cancellous bone

Question 4

Osteoconduction

Answer 4

New bone from host derived or transplanted osteoprognetori cells along bio framework

Provide only passive framework or scaffolding does not produce bone

Question 5

Osteogensis

Answer 5

Form new bone from osteoprogenitor cells

have osteoindcutve and conductive properties

Question 6

osteogenesis only in

Answer 6

autogenous only

Question 7

Phase 1 osteogenis

Answer 7

Transplanted cellular bone produces new osteoid
Considerable cell death may not lead to impressive regeneration
Most active within 4 weeks

Question 8

Amount bone generated depends on

Answer 8

survival amount of transplanted OSB

Relies on external blood supply to diffuse through
BMPs brought in cause surrounding bone to develop into new bone

Question 9

Phase II osteogenesis

Answer 9

Angiogeneis and fibroblastic proliferation from graft bed after grafting

Osteogenesis from host CT soon begins
will only grow in wherever phase I lived

Initial woven bone resorbed and replaced by lamellar bone; as initial graft resorbed BMPs released from matrix

begins at 2 weeks peaks at 6 weeks

Question 10

Autograft

Answer 10

Gold standard
Same inidvidual

possible osteogenic properties

2 surgical sites

Question 11

Calvarium

Answer 11

good for nasal or large facial fractures thin

can’t go deep mostly cortical bone grafts

Question 12

Rib

Answer 12

Can harvest with cartilage for TMJ

costochondral grafts good to restore TMJ in growing patients

Question 13

Pedicel grafts

Answer 13

fibula radial forearm

Question 14

Antioer poster iliac creast

Answer 14

Young patient with ameloblastoma of mandible

Question 15

if mostly cortical bone

Answer 15

may not have osteogenic potential

Question 16

Free Flap

Answer 16

lots of bone different no phase i or 2

have to reanastamose BV

Question 17

Allograft/Homograft

Answer 17

Same species (cadaver) Highly processed
what perio uses

Osteoconductive-good framework minimal induction

Question 18

Allograft advantages

Answer 18

replaced by patients own bone
no do not site morbitidy
readily available

Question 19

Allograft disadvantages

Answer 19

No viable cells for phase I osteogenisis
longer cosnolidation period
encapsulation
disease transmision
graft host ruction
expenisve

Question 20

Xenograft

Answer 20

Different species
Osteoconductive; possible carrier for inductive properties
Less processed than allograft
limitless no donor site morbidity

expense
longer consolidation period
diseae
patient acceptance

Question 21

Alloplast

Answer 21

Synthetic not of human or animal think plastic

Osteocondcutive- carries inductive proteins
silicon glass bead calcium phosphate hydroxypatie

Question 22

alloplast disadvanted

Answer 22

prolonged consolidation
foreign body
encapsulation
cost

Question 23

Recombinate Graft

Answer 23

recombinant BMPs 2 and 7

Question 24

BMP 2

Answer 24

approved for sinus floor augmentation and mandibular defect graft

good site because protected by walls

Question 25

Recomb disadvantages

Answer 25

does not hold shapes flattens out expesnive swelling sterility

Question 26

socket grafting

Answer 26

small volume allograft or xenograft sufficient | osteocondcution adequate to produced desired healing

Question 27

Sinus floor augmentation

Answer 27

small defects--> allogenic or xenogeneic Larger--> BMP carrier or autogenous bone iliac crest or tibia

Question 28

Only grafting for implants

Answer 28

autogenous intraoral donor sites or iliac crest Resotre both vertical and horizontal ridge drefcines