L10 - Tumor Virus

Question 1

Describe the steps to the life cycle of viruses.

Answer 1

1. Viral entry:
   - Interaction between virus and host cell receptor
   - Endocytosis into endosome
   - replication of viral genome: NP-coated (-) strand RNA enters nuclei and used to make (+) strand which can further be used to make (-) strand
2. Viral replication:
   - virus take control of host cell’s replication mechanism
   - susceptibility vs permissibility (determines outcome of infection)
3. Viral shedding:
   - after exhausting all the host cell’s resources, virus progeny are released
4. Viral latency/lysogenic virus:
   - virus hide within the cell and remains inactive until external stimulus

Question 2

Describe how viruses respond to temperature changes.

Question 3

Why cant viruses replicate independently?

Answer 3

Viral genome lacks genetic elements (centromere)

Question 4

What is pleiotropy?

Answer 4

Used to describe proto-oncogene where a single gene activation is sufficient for cellular transformation