L101: Kidney 1 Flashcards

(40 cards)

1
Q

What type of organ are the kidneys?

A

Excretory

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2
Q

What are the two main functions of the kidneys?

A
  • Filter blood and produce urine;
  • Maintain internal homeostasis*.
  • fluid, BP, acid/ base, erythropoietin, Ca, Vit D, electrolytes
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3
Q

What is the function of the ureters?

A

Convey urine

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4
Q

What is the function of the bladder?

A

Store urine

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5
Q

What is the function of the urethra?

A

Void urine

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6
Q

What supplies blood to the kidneys?

A

Abdominal aorta (via renal arteries)

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7
Q

What drains the blood from the kidneys?

A

Inferior vena cava (via renal veins)

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8
Q

At what anatomical feature do arteries and veins join to the kidneys?

A

The hilum of the kidneys

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9
Q

What is the peritoneum?

A

A serous membrane forming the lining of the abdominal cavity

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10
Q

What is the name of the structure that supports and protects the kidneys?

A

Renal fat pad

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11
Q

In the macroscopic structure of the kidney, what are the three main parts?

A
  • Pelvis;
  • Medulla;
  • Cortex.
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12
Q

Which part of the kidney contains the majority of nephrons?

A

Cortex - 85%

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13
Q

Where is urine concentrated, to prevent excess water loss, in the kidneys?

A

Medulla

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14
Q

What happens in the pelvis of the kidney?

A

Collection of urine which is then funnelled into the ureter

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15
Q

How much blood is processed by the kidneys per minute?

A

1.2L

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16
Q

The kidneys are highly vascular organs, what is the main sequence of blood flow from the renal artery?

A
  • Afferent arterioles -
  • Glomerular capillaries -
  • Efferent arterioles -
  • Peritubular capillaries.
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17
Q

How are the peritubular capillaries adapted for their function?

A

Vasa recta are U-shaped for greater absorbance

18
Q

What are the two types of nephron?

A
  • Cortical (short, LofH, 85%);

- Juxtamedullary (long, 15%).

19
Q

In the kidneys, where does filtration occur?

A

In the renal corpuscle

20
Q

What are the major components of the renal corpuscle?

A
  • Bowman’s capsule;

- Glomerulus.

21
Q

In the kidneys, where does reabsorption and secretion occur?

A

In the renal tubule

22
Q

What are the major components of the renal tubule?

A
  • PCT;
  • L of H;
  • DCT.
23
Q

What is a glomerulus?

A

A network of fine capillaries within the Bowman’s capsule

24
Q

How does the structure of the capillaries of the glomerulus assist ultrafiltration?

A
  • Surrounded by a single layer of endothelial cells (fenestrated - pores);
  • Basement layer;
  • Podocytes with pedicels
25
What cannot pass through the ultrafiltration barrier?
- Large cells inc. rbc; - Negatively charged molecules; - Large proteins; - Serum albumin.
26
What is the Bowman's capsule?
- Cuplike structure surrounding the glomerulus; - Bowman's space allows for filtered components to be captured; - Visceral (inner) layer; - Pareital (outer) layer.
27
How is the visceral layer of the Bowman's capsule specialised?
Podocytes, with pedicel projections that wrap around the glomerular capillaries
28
What are the major components of the filtration barrier?
- Fenestrated glomerular endothelium; - Basement membrane; - Pedicels of podocytes.
29
What can pass through the ultrafiltration barrier?
- Water; - Glucose; - Amino acids; - Urea; - Creatinine; - Ions: Ca2+, Cl-, HCO3-, K+, PO4, Na+.
30
What constitutes to hydrostatic pressure within the glomerulus?
Wider afferent arteriole to efferent arteriole
31
What is glomerular filtration rate (GFR)?
The rate at which blood is filtered through the glomerulus into the Bowman's capsule
32
What forces favour glomerular hydrostatic pressure? | i.e. push fluid out of the glomerulus
- Glomerular hydrostatic pressure; | - Capsular osmotic pressure.
33
What forces counteract glomerular hydrostatic pressure? | i.e. push fluid into the glomerulus
- Glomerular osmotic pressure; | - Capsular hydrostatic pressure.
34
What primarily drives GFR?
Glomerular hydrostatic pressure
35
What primarily counteracts GFR?
Capsular hydrostatic pressure
36
What counteracts capsular hydrostatic pressure?
Glomerular osmotic pressure
37
What is normal, healthy GFR?
125mL/ min, 180L/ day.
38
How does CKD effect GFR?
CKD decreases GFR - insufficient blood clearance and waste removal - accumulation of waste in the blood
39
What blood component can be measured as an estimate of kidney function?
Creatinine
40
How does the level of creatinine change in the blood of a patient with CKD?
Creatinine levels increase as CKD progresses (lower blood clearance)