L11:Cestodes Flashcards

1
Q

How does the male system of cestodes develop

A

=>developes in proglottid
=>formation starts in the immature proglottid and completes in the mature proglottid
=> the organs disappear in gravid proglottid

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2
Q

Describe the morphology of adult cestodes

A

elongated, billatery symetrrical, dosroventrally flat and segemented

scolex: anterior, attachment structures
cyclophilidea has 4 suckers and maybe hooks
other pseudophyllidea has slits called bothria

neck: only unsegmented region posterior to scolex, origin of proglottid

strobila: chain of proglottid each are independant functioning units, move down as more are formed
so there are the immature newly formed, mature proglo with male and femal reprodutive organs and gravif with embryonated eggs

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3
Q

What are cestodes, general characteristics

A

=>monoecious, hermaphroditic
=>self and cross-fertilisation
=> genital pore where eggs exit
=> gravid proglottid detach from parent and disintegrate or exit the host
=> Male and female organs absent from gravid proglottid

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4
Q

What is the male reproductive system made of in cestodes

A
  1. one or many testes depending on species
  2. Vas efferents which is tubular structure that transports spermatozoa from testes
  3. A tightly coiled cas derefense for transporting sperm
  4. seminal vesicle to store the sperm
  5. cirrus sac cirrus - male copulatory system
  6. male genital pore that opens to common genital atrium
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5
Q

Where does the female reproductive system develop from

A

Form only in the mature proglottids and are functional from there

*only the egg-filled uterus remains in the gravid proglottid

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6
Q

What are the structures of the cestode female reproductive system

A
  1. single ovary where ova is produced
  2. oviduct
  3. vagina that carries the sperm to the ootype
  4. ootype which is a region in oviduct where fertilisation and egg assembly happen
  5. Vitellaria yolk gland where yolk and eggshells form
  6. Mehli gland that secretes essential eggshell material
  7. Tubular uterus that contains egg in branches
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7
Q

What are the general characteristics of cestodes reproductive system eggs

A
  • eggs are passed from the host are mostly embryonated
  • eggs contain hexacanth larvae called ONCOSPHORES

*oncosphere has 3 pair of hooks and encased in inner envelope surrounded by a second membrane called an embryophore

*the embryophore is also encased in outer membrane

*shell or capsule encapsulates the egg

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8
Q

whats an oncophores

A

eggs that contain hexacanth larva

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9
Q

What are the types of eggs in cestodes1

A
  1. operculated with immature embryo passed into the environment
  2. non-operculated with embryonated embryo when passed into the environment
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10
Q

Discuss how eggs pass into the environment generally with cestodes

A

Eggs remain viable in the external environment for weeks to months

released as operculated or non-operculated

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11
Q

What is the tegument, what is it composed of and key roles of each

A

skin that covers the entire external surface
=> microthrices microvilli for:
movement
surface area to absorb nutrients
sensory + secretory

glycocalyx carbohydrate layer covering tegument for:
protection from digestive enzymes, nutrient absorption, maintain surface membrane

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12
Q

Why is absorption so important

A

Flatworms don’t have a digestive tract so all nutrients are derived from host molecules, meaning they must cross tegument

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13
Q

What is the purpose of the osmoregulation/excretory system, what are the two key cells

A

maintains optimal hydrostatic pressure in the worm for extensory movements of the strobila and scolex with two components

The flame cells and the Collecting canals

flame cells: ciliated cells forming the basic unit of the excretory system

Collecting Canals: carry water to and away from scolex, running the length of strobila

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14
Q

What is the excretory system, cells, caviat in some species. What is the connection between osmo and exec system

A

some species the osmo/excre system is only excre because they cannot regulate osmotic pressure and change movement to environment

the excre system ensure survival as host can conserve water and eliminate salts, allowing them to maintain osmo pressure

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15
Q

What are the characteristics of the nervous system in cestodes?

A

brain is scolex and main nerve center of cestode

the nervous system is like ladder and the nerves run anteriorly and posteriorly in the body

many sensory organs arranged species-specifically

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16
Q

What is the basic life cycle of cestodes - 5

A

They are obligate parasites

include trophic transmission but not H.nana

life stages includes worms, larvae, eggs

adults stay in alimentary track of definite predator host

larval stage infect 1 or more intermediate vertebrate/invertebrate prey host

17
Q

What are two taenia species of medical of economic importance

A

Taenia saginata and solium

18
Q

What is T. saginata vs solium

A

most common tapeworm

Beef tapeworms
humans are only def host, causes taeniasis in humans

Cattle are intermediate hosts, causes bovine cysticercosis

pork tapeworm, worse than saginata
Humans are the only definitive host, causing taeniasis/cysticercosis. humans can be an accidental host

pork are only intermediate host, causing porcine cysticercosis

19
Q

Describe key characteristics of T. saginate and T.solium

A

T saginata
*scolex has 4 suckers without hooks
*mature adult worm are 5-10m long
*strobilla is 1-2K proglattids, with 50K-100K eggs

T solium
*scolex has 4 suckers and 2 circle hooks
*2-3 meters long, 700-1000 proglattids each with 50K eggs

20
Q

Breakdown Taenia life cycle

A

Eggs / gravid proglottid: infection
Oncospheres
Cysticerci larvae’s
Invaginayed scolex in intermediate and evaginate in defeinitie

21
Q

Describe Taenia species csystercisus

A

ovoid, fluid-filled and contains invaginated scolex

22
Q

Compare and contrast Taenia species life cycle

A

*In Cattles and Pigs cannot be ifnected with adult ingest because cysticerci will not evaginate in the gut

*humans cannot harbor cycsteri because eggs will not hatch in stomach for saginate

*BUT CAN be infected by solium because they can hatch in stomach

23
Q

Explain Taenia Solium Cysticercosis, why so bad? How infected, routes of transmission

A

?: caused by ingestion of eggs shed in feces of human tapworm carrier, immediately infectious and do not need a developmental period outside of the host

  1. humans and pigs are exposed from ingesting egg/gravig proglattid exposed via fecal oral route, person-perosn contact, autoinfection
  2. In intestine, oncospheres hatch from ingested eggs and invade the intestinal wall, go to blood, go to organs/tissue
  3. from tissue, they mature into cysterci and migrate to brain / nervous system
24
Q

What is the clinical presentation of T.saginata

A

*Saginata only 1-2 needed for infection but Solium needs 1
*not too bad, abdominal pains, loss of appetite, weight loss
*worse if patient already is malnutritioned
*Saginata: appendecitits/cholangtis
* Solium hooks may cause irritation => peritonitis

25
Q

Clinical presentation of cysticercosis, generally and 4 main complications

A

typical: skeletal muscles/brain, muscle spams, weakness

  1. immune system => inflammatory -> cyst encased in fibrous tissue => calcification
  2. Dead and dying cysts cause the host immune to parasite => fatal inflammatory response
  3. in brain/CNS => epilepsy => fatal
  4. extracebral cysticerosis can exert mechanical pressure => fatal
26
Q

Tanaea epidemiology

A

worlwide, migrants, low middle income, common contaminant is fertiliser

27
Q

Taenia diagnosis

A

Taeniasis:
* recover eggs proglottid from feces/clothing and identify head when expelled after treatment

Cysticercosis:
* immunodiagnostics with parasite antigen, seen on Xray or MRI

28
Q

Taenasis / cysticercosis treatment

A

T:
*praziquontal which disrupts caclium ion homeotstatis and increases permeability of worms membrane to calcium ions => uncontrolled muscle spasms => paralysis => dislodged from wall => poop
*albendazole causes degeneration of microtubles by stopping ATP production/glucose => energy gone

C:
*might not be required, anti parasitc/inflammatory drugs, surgery to remove