L1.2 haematopoesis Flashcards
(49 cards)
whats in normal peripheral blood
platelts, white cells, RBC
what is haematopoiesis (HMP)
blood cell production
where does HMP occur in infants
in all bone-bone marrow
where does HMP occur in adults
bone marrow- axial sketelton
pathway from LTHSC to mature cells
LTHSC>multipotent progenitors>oligopotent progenitors>lineage commited proginators> mature cells
stem cell meaning
can divide infinetiityl, self renew and give rise to specialised, diff cells
what is multi potent cells
rise to diff cell depending on the organ they devrive from
what is pluripotent cells
rise to any kind of cells regardless of organ and location
what technique can detect stem cell and progenitor
functional assay
what technique can detect precursor and mature cells
by routine marrow staining
when does HMP start after fertilisation
after 17 days
types of blood cells
RBCS, platelets, WBC
types of WBC s
lymphoid and myeloid cells
types of lymphocyates
T, B, NK cells
where does T cells develop
start in bone marrow then migrate to thymus to develop
where does b cells develop
in bone marrow
where does NK cell develpo
bone marrow
how to distinguish stages of granulocyte maturation stages
N:c ratio
what are monocyte maturation stages
monoblast>promonocyte>monocyte
what is innate immunity
barriers that keep harmful materials from entering your body
what does neutrophils contain to get rid of bacterial infections
lysosome and myeloperoxidase
what infection are eosinophils involved in
parasite infections - not phagoctic
what do monocytes become after migrating to tissues from bloof
macrophages
are monocytes phagoctic
yes
