L13 drugs

Question 1

metyrosine

Answer 1

indiction: hypertension
MOA: Competitive inhibition of tyrosine hydroxylase

Question 2

Reserpine

Answer 2

indication: Hypertension
MOA: Inhibits VMAT uptake of monoamines

Question 3

Bretylium

Answer 3

Indication: Ventricular Arrhythmia
MOA: Inhibit action potential generation and calcium dependent synaptic vesicle fusion

Question 4

Cocaine

Answer 4

indication: Analgesia in surgery
MOA: Blocks monoamine reuptake

Question 5

Amphetamine or

Ephedrine

Answer 5

Indication: Narcolepsy, ADHD
MOA: Reverse monoamine reuptake transporters

Question 6

Naloxone,

Naltrexone

Answer 6

Indication: Opioid overdose or dependence
MOA: Non-peptide blockers of opioid receptors in CNS

Question 7

SSRIs

Answer 7

indication: Depression/anxiety
MOA: Selective inhibition of serotonin reuptake transporter

Question 8

ACE inhibitors

e.g., lisinopril

Answer 8

Indication: Hypertension
MOA: Inhibits peptide cleavage of Angiotensin I to Angiotensin II

Question 9

Phenylephrine

Answer 9

indication: Hypotension during surgery
MOA: Direct agonist of adrenergic receptor

Question 10

MAO inhibitors

Answer 10

indication: Depression
MOA: Blockade of cytoplasmic metabolism of monoamines

Question 11

L-DOPA

Answer 11

indication: Parkinson’s Disease
MOA: Precursor of dopamine, stimulates dopamine production

Question 12

Carbidopa

Answer 12

indication: Parkinson's Disease 
MOA: Blocks L-DOPA conversion to
dopamine. (does not cross BBB, so
protects peripheral adrenergic
neurons from producing too much
dopamine and norepinephrine)

Question 13

Tyramine

Answer 13

indication: Ingested in diet, not therapeutic
MOA: Competes with NE for transport
into synaptic vesicle