L.16 Cancer Screening Programmes Flashcards

(62 cards)

1
Q

What is the main purpose of the cancer screening programmes in Ireland?

A

To reduce cancer burden, provide optimal care, maximise patient involvement and quality of life, and enable system improvements.

These goals follow the 2006 strategy and address rising cancer incidence, infrastructure gaps, and emerging therapies.

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2
Q

Define cancer screening.

A

Early detection of life-threatening disease in asymptomatic populations.

This definition highlights the focus on identifying cancer before symptoms appear.

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3
Q

List the three population-based cancer screening programmes currently in place.

A
  • Breast
  • Cervical
  • Colorectal

These programmes are designed for early detection in specific populations.

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4
Q

Are there current recommendations for population-wide prostate and lung cancer screening in Ireland?

A

No current recommendation for population-wide programmes.

Ongoing research is essential to refine methods and technologies for these types of cancer.

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5
Q

What are the principles of effective screening according to Wilson & Jungner (1968)?

A
  • Disease must be a significant health problem
  • Natural history well understood with a detectable early stage
  • Test should be appropriate, acceptable, and done at suitable intervals
  • Early treatment should offer advantage
  • Adequate diagnostic & treatment facilities must be available
  • Benefit of screening should outweigh potential harm
  • Programme costs should be justified by benefits

These principles ensure that screening is effective and justifiable, particularly for asymptomatic individuals.

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6
Q

What is one objective of cancer screening programmes?

A

Prevent disease development within the target population.

Other objectives include detecting cancer early when treatment is effective and sometimes screening for risk factors or genetic markers.

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7
Q

Fill in the blank: The first step in implementing a cancer screening programme is to decide the type of screening: _______ vs risk factor identification.

A

early detection

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8
Q

What should be ensured in evidence-based practice when implementing a cancer screening programme?

A
  • Research international best practices
  • Consult WHO/EU guidelines
  • Assess local data on prevalence & outcomes
  • Review HIQA HTA reports

These steps help in making informed decisions and improving screening effectiveness.

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9
Q

True or False: The benefit of screening should outweigh potential harm.

A

True

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10
Q

What is a key aspect of the natural history of a disease in effective screening?

A

It must be well understood with a detectable early stage.

This understanding is crucial for developing effective screening tests.

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11
Q

What is Sensitivity in test performance?

A

Ability to detect true positives

Formula: True Positive / (True Positive + False Negative)

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12
Q

What is Specificity in test performance?

A

Ability to correctly identify disease-free individuals

Formula: True Negative / (True Negative + False Positive)

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13
Q

What does Positive Predictive Value (PPV) indicate?

A

Likelihood that a positive test indicates actual disease

Formula: True Positive / (True Positive + False Positive)

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14
Q

What are key indicators of Programme Performance?

A
  • Reduction in mortality & morbidity
  • High population uptake (coverage)
  • Regular audits to monitor & improve outcomes

These indicators help assess the effectiveness of screening programmes.

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15
Q

What are the main cancer types involved in histology and cytology?

A
  • Breast Cancer Screening (mammography, biopsy)
  • Cervical Cancer Screening (HPV testing, cytology)
  • Colorectal Cancer Screening (FOBT, FIT, colonoscopy, biopsy)

These methods are critical for early detection.

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16
Q

What is the role of the National Cancer Control Programme (NCCP) in Ireland?

A

Oversee population-based cancer screening programmes aimed at early detection, prevention, and reduction of cancer-related mortality

The NCCP follows evidence-based recommendations.

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17
Q

List the current cancer screening programmes in Ireland.

A
  • Breast Screening — BreastCheck
  • Cervical Screening — CervicalCheck
  • Colorectal Screening — BowelScreen

These programmes are designed for early detection.

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18
Q

What potential future cancer screening programmes are under consideration in Ireland?

A
  • Prostate Cancer Screening
  • Lung Cancer Screening

These programmes are being reviewed based on emerging research and cost-benefit analyses.

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19
Q

What is BreastCheck?

A

A breast cancer screening program for women aged 50–69 years

Originally targeted women aged 50–64, but extended to 69 by 2021.

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20
Q

What is the aim of BreastCheck?

A

Detect breast cancer in the asymptomatic, pre-clinical phase

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21
Q

What is the rationale for BreastCheck?

A
  • High prevalence of disease
  • Early detection improves treatment outcomes
  • Mortality reduction by 20–30%
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22
Q

What screening method does BreastCheck use?

A

Mammography (X-ray imaging of the breast)

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23
Q

What system is used for organizing BreastCheck screenings?

A

Organised call and recall system for eligible women

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24
Q

What is the diagnostic follow-up procedure in BreastCheck?

A
  • Trucut biopsy of suspicious lesions
  • Histopathological examination for definitive diagnosis
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25
What role does histopathology play in BreastCheck?
* Morphological assessment of biopsies and excisions * Frozen sections for intraoperative consultation * Biomarkers for prognosis and treatment decisions
26
What biomarkers are assessed in BreastCheck?
* Oestrogen and Progesterone Receptor Status (ER/PR) * HER2 status (with FISH for equivocal cases)
27
What is CervicalCheck?
A cervical cancer screening program for women aged 25–60 years
28
What is the aim of CervicalCheck?
Early detection of pre-malignant and malignant cervical lesions
29
What is the rationale for CervicalCheck?
* High prevalence of HPV-related disease * Effective treatment available at pre-invasive stages * Mortality reduction up to 80%
30
What screening method was initially used in CervicalCheck?
Cervical cytology (Pap smear)
31
What is the current primary screening method for CervicalCheck?
HPV testing (since March 2020)
32
How is cytology used in CervicalCheck now?
As triage for HPV-positive cases
33
What evidence guided the evolution of CervicalCheck?
HIQA HTA Report (2017) recommended HPV testing as primary screening
34
What specimen types are used for histology in CervicalCheck?
* LLETZ (Large Loop Excision of the Transformation Zone) * LEEP (Loop Electrosurgical Excision Procedure) * Cone biopsy, hysterectomy specimens * Complete uterine and adnexal tissues (fallopian tubes, ovaries)
35
What are some special considerations for CervicalCheck?
* Updated cytology reporting standards * CervicalCheck controversy led to programme reviews and reforms
36
What is the target population for colorectal cancer screening?
Adults aged 55–74 years (initially 60–69) and high-risk groups with family history of colorectal cancer ## Footnote High-risk groups include individuals with hereditary nonpolyposis colorectal cancer (HNPCC)
37
What is the aim of colorectal cancer screening?
Detect pre-cancerous polyps and early-stage colorectal cancers
38
What are the reasons for colorectal cancer screening?
* High disease burden * Screening reduces incidence and mortality
39
What method is used for colorectal cancer screening?
Faecal Immunochemical Test (FIT)
40
How often is colorectal cancer screening conducted?
Every 2 years
41
What is the next step for individuals with positive FIT results?
Colonoscopy
42
When was the national colorectal cancer screening programme established?
2012
43
What was the goal for the number of screens by 2015 in the colorectal cancer screening programme?
500,000 screens
44
Under which recommendation does the colorectal cancer screening continue?
Recommendation 5 of the National Cancer Strategy (2017–2026)
45
What is the current position on prostate cancer screening?
No national screening programme due to insufficient evidence
46
What does the National Cancer Strategy 2017–2026 recommend regarding prostate cancer screening?
Does not recommend implementation
47
What are some challenges faced in prostate cancer screening?
* Poorly understood natural history of prostate cancer * Controversies in optimal treatment of localized disease * Balancing benefits vs. side effects of treatment
48
What screening methods have been explored for prostate cancer?
* Digital Rectal Examination (DRE) * Prostate-Specific Antigen (PSA) testing * Transrectal Ultrasound (TRUS)
49
What ongoing studies are being conducted regarding prostate cancer screening?
Ongoing RCTs (Europe and USA)
50
What did the European Randomised Study of Screening for Prostate Cancer find?
A 20% reduction in prostate-specific deaths but at high costs and with potential harms
51
What is the current position on lung cancer screening?
No formal screening programme due to limited evidence
52
Who is the focus of lung cancer screening efforts?
High-risk groups, particularly heavy smokers
53
What screening method has been evaluated for lung cancer?
Low Dose Helical Computed Tomography (LDCT)
54
What did studies in the USA about lung cancer screening show?
A 20% mortality reduction in heavy smokers
55
What is a significant issue with lung cancer screening?
High false positive rate (~25%) leading to unnecessary invasive procedures
56
What methods have been found ineffective in reducing lung cancer mortality?
* Sputum cytology * Chest X-rays
57
What role do biomarkers play in cancer screening?
Identifying high-risk groups for specific cancers
58
What mutations are associated with high-risk groups for breast cancer?
BRCA1, BRCA2 mutations
59
What mutations are associated with high-risk groups for colorectal cancer?
HNPCC (Lynch Syndrome) mutations
60
What is the current use of genetic testing in cancer screening?
Offered to individuals/families at high risk
61
Is genetic testing recommended for population-wide screening?
Not yet recommended
62
What does Recommendation 6 of the National Cancer Strategy 2017–2026 support?
Further research into biomarker-driven screening strategies