L.2

Question 1

The Gastrointestinal motility and secretion controlled by a great number of GIT hormones which ………….. secreted by……

Answer 1

polypeptides , special mucosal cells

Question 2

The special mucosal cells in the GIT are called :

Answer 2

enteroendocrine or APUD احفظوها على انو شخص اسمو (عبود)

Question 3

Hormonal regulation for GIT function They are classified into:

Answer 3

­• Gastrin family

­• Secretin family

• Other hormones

Question 4

­Gastrin family:

Answer 4

• Gastrin
• cholecystokinin (CCK)

Question 5

Secretin family :

Answer 5

• Secretin
• gastric inhibitory peptide (GIP)
• vasoactive intestinal peptide (VIP).

Question 6

The other hormones that regulation of GIT function :

Answer 6

• Motilin
• somatostatin
• gastrin releasing peptide (GRP or bombesin)

Question 7

What is the 3 forms of Gastrin that classified according to the number of A.A?

Answer 7

• G 14
• G17 (little gastrin )
• G 34 (big gastrin )

Question 8

The Gastrin  It is secreted by……. In…………

Answer 8

• G cells
• in the antral mucosa of the stomach

Question 9

The section of Gastrin is stimulated by Luminal factors which is :

Answer 9

• Gastric distension decreased gastric acidity (انتفاخ المعدة يعني ““اذا اكلت كتير وشبعت “” حتتقلل حموضة المعدة ) + ( Gastrin يقل يطلع ال acidityلمن ال )

• Presence of “protein digestive” products in the stomach

دي العوامل الي تخلي ال Gastrin يطلع

Question 10

The action of Gastrin :

من حيث ال stimulation

Answer 10

• Stimulation of gastric motility and secretion especially HCl معلومة للفهم —> (HCL اذا زاد , Gastrin hormone will stop)

• Stimulation of small intestinal motility

• Helps normal growth of GIT mucosa

Question 11

The action of Gastrin :

Answer 11

• “Contraction of lower esophageal sphincter” preventing reflux of gastric contents into
the esophagus بالفهم حتتبسط

• Relaxation of ileocecal sphincter | للتوضيح ( ileocecal open and the food pass through it to small intestine then to large intestine )

Question 12

How many amino acid is Cholecystokinin containing

Answer 12

33 amino acids

Question 13

Cholecystokinin It is secreted by……. in the……

Answer 13

• I cells
• duodenal and jejunal mucosa

Question 14

The section of Cholecystokinin is stimulated by :

Answer 14

• Protein digestive products
• Long chain fatty acids

Question 15

Thr Action of Cholecystokinin according the stimulation:

Answer 15

• Stimulation of enzymatic pancreatic secretion
(small in volume, poor in HCO3- and “rich”in enzymes).

• Stimulation of intestinal motility.

Question 16

The Action of Cholecystokinin :

Answer 16

• Contraction of pyloric sphincter

• Contraction of gall bladder

• relaxation of the sphincter of Oddi which causes evacuation of the gall bladder

• Inhibition of gastric emptying and secretion

Question 17

The Cholecystokinin Augmenting the action of :

Answer 17

secretin

Question 18

How many amino acid is Secretin containing ?

Answer 18

22 amino acids

Question 19

Secretin It is secreted by……. in the……

Answer 19

• S cells
• duodenal and jejunal mucosa.

Question 20

The section of Secretin is stimulated by :

Answer 20

• Arrival of acid chyme with PH < 4.5 to the duodenum

•Protein digestive and Fatty acids

Question 21

The Secretin Augmenting the action of :

Answer 21

Cholecystokinin (CCK)

Question 22

Gastric inhibitory peptide (GIP) It is secreted by……. in the……

Answer 22

• K cells
• mucosa of the duodenum and jejunum

Question 23

Gastric inhibitory peptide (GIP) It’s secreted in response to presence of :

Answer 23

• Fat
• Carbohydrates

Question 24

The action of Gastric inhibitory peptide (GIP) :

Answer 24

• It decreases the gastric emptying into the duodenum.

when the upper small intestine is over supplied with food products

يعني ال GIP يقول للstomach كفااية اكل

Question 25

Vasoactive intestinal peptide (VIP) It is secreted from……

Answer 25

upper part of small intestine

Question 26

The action of Vasoactive intestinal peptide (VIP) :

Answer 26

• vasodilation of intestinal blood vessels • Regulation of gastrointestinal motility •Stimulation of pancreatic NaHco3 secretion. • Inhibition of gastric secretion

Question 27

Motilin It is secreted by…….. scattered in……

Answer 27

• special cells (mo cell) • small intestine

Question 28

The action of Motilin :

Answer 28

• Stimulation of antral and duodenal motility • Contraction of lower esophageal sphincter.

Question 29

Somatostatin It’s Secreted from……. and……..

Answer 29

• stomach • upper part of the small intestine

Question 30

The action of Somatostatin :

Answer 30

Inhibition of secretion of gastrin and secretin

Question 31

‏The Action of Secretin according the stimulation:

Answer 31

• Stimulation of aqueous pancreatic secretion (large in volume, rich in HCO3- and poor in enzymes) • Contraction of pyloric sphincter. • Inhibition of gastric motility and secretion. "Secretin loves bicarbonate and hates acidity"