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4BBY1020 - Chemistry for the Biosciences > L20 > Flashcards

Flashcards in L20 Deck (2)
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1
Q

Chymotrypsinogen:

A

Precursor. Enzymatically inactive. Cleaved by trypsin but held together by disulphide bonds.

2
Q

Chymotrypsin:

A

Protease. Cuts polypeptides into smaller fragments. Contains 245 amino acids.
3D structure was determined by crystallography.
Mainly B-sheets and a few a-helices.
Made in pancreas and used in digestive system. Cleaves peptide bond near large hydrophobic amino acids by nucleophilic substitution forms acid and amine.