L34 - Distribution Part 1 Flashcards
(3 cards)
Drug distribution (definition)
The reversible transfer of a drug from one site to another within the body.
Perfusion rate (definition)
- Rate of blood flow to a tissue/organ.
- Key factor in kinetics of drug distribution.
An “average” person has…
- 5L of blood
- 3L of plasma
- Cardiac output of 5.5 L/min (at rest)
Most if not all blood in the body is pumped through the heart per min. —> drug distribution = quick in systemic circulation