L34 - Distribution Part 1

Question 1

Drug distribution (definition)

Answer 1

The reversible transfer of a drug from one site to another within the body.

Question 2

Perfusion rate (definition)

Answer 2

• Rate of blood flow to a tissue/organ.
• Key factor in kinetics of drug distribution.

Question 3

An “average” person has…

Answer 3

• 5L of blood
• 3L of plasma
• Cardiac output of 5.5 L/min (at rest)

Most if not all blood in the body is pumped through the heart per min. —> drug distribution = quick in systemic circulation