L5 Cell Adhesion Molecules

Question 1

Cadherins bind to?

Answer 1

Cytoplasmic Actin

Question 2

Selectins bind to?

Answer 2

Carbohydrates

Question 3

Cadherins are what type of adhesion proteins?

Answer 3

Calcium Dependant

Question 4

Selectins are what type of Adhesion proteins?

Answer 4

Calcium Dependant

Question 5

Desmogleins and Desmocollins are what type of molecules? Found where?

Answer 5

Cadherins - found in desmosomes

Question 6

What are 3 common types of Cadherins and where are they found?

Answer 6

E- Cadherin - epithilial cells
P-Cadherin - Placenta
N-Cadherin - nervous System

Question 7

What are 3 common types of Selectins and what are their associations?

Answer 7

P-selectins - Platelets
E-selectins - endothelial cells
L-Selectins - leukocytes

Question 8

What is the function of Catenins?

Answer 8

link cytoplasmic end of cadherin to the cytoskeleton actin.

Question 9

How many forms does Catenin have? name them

Answer 9

3 forms, alpha,beta , gemma.

Question 10

Integrins are what type of Adhesion proteins?

Answer 10

Calcium independant

Question 11

Ig superfamily molecules are what type of Adhesion molecules?

Answer 11

Calcium independant

Question 12

N-CAM is what type of molecules

Answer 12

immunoglobulin superfamily molecule

Question 13

I-CAM is what type of molecule?

Answer 13

immunoglobulin superfamily molecule

Question 14

CAM-2 Is what type of Molecule?

Answer 14

immunoglobulin superfamily molecule

Question 15

What are the functions of Integrins? (multiple)

Answer 15

bind extracellular matrix and cytoskeleton actin. Act as bi-directional signalling molecules.

Question 16

E-Cadherins bind via what sequence?

Answer 16

HVA-sequence

Question 17

Integrins Bind via which Sequence with fibronectin and laminin?

Answer 17

RGD-sequence

Question 18

What is the function of I-CAM and CAM-2

Answer 18

Facilitates transendothelial migration of leukocytes

Question 19

Integrins use what to link hemidesmosomes to the basal domain?

Answer 19

Extracellular Tonofilaments(intermidate filaments).

Question 20

What are the components of the Basal lamina

Answer 20

Laminin, Fibronectin, Type 4 collagen, entactin, and proteoglycans.

Question 21

Laminin binds to what?

Answer 21

Has binding sites for integrins, type 4 collagen, entactin, proteoglycans.

Question 22

Fibronectin binds to what?

Answer 22

Heparin (entactin), integrins, collagen, and fibrin.

Question 23

Type 4 collagen is produced by what?

Answer 23

Epithelial cells

Question 24

Zonula Adherens have what characteristics

Answer 24

Are belt-like structure made from cadherins (desmogleins and desmocollins) and associate with cytoskeletal actin. Keeps tissues together

Question 25

Zonula Occludens have what characteristics?

Answer 25

A belt-like security barrier that is impermeable and stops para-cellular transport. maintains environment.

Question 26

Gap Junctions have what characteristics?

Answer 26

Are built from 6 units of connexons. Is a pore that enables rapid exchange of ions between cells. helps with multicell coordination.

Question 27

Macula adherins have what characteristics?

Answer 27

spot-like junction that reinforce tissue integrity. often associated with intracellular intermediate filaments(tonofilaments)

Question 28

What are some genetic mutation associated with integrins

Answer 28

Skin diseases and leukocyte adhesion deficiency.

Question 29

What are the 2 main functions of tight junctions?

Answer 29

Determine epithelial cell polarity and prevent passage of substances between cell layers

Question 30

What are the three anchoring junctions typically found under the tight junctions?

Answer 30

Zonula Adherens Macula Adherens Hemidesmosome

Question 31

Zonula adherens has what characteristics?

Answer 31

beltlike junction that is associated with actin microfilaments. mediated by cadherens via catenins.

Question 32

Macula Adherens has what characteristics?

Answer 32

Spotlike junction associated with keratin intermediate filaments. provide strength and rigidity to the cell layer.

Question 33

Autoimmune disease that targets desmoglein causes what effect in that individual?

Answer 33

Blistering occurs due to weak linkages in macula adherens.

Question 34

Hemidesmosome structure is composed from what?

Answer 34

Inner cytoplasmic plate - bound to tonofilaments | outer membrane plaque - bound via anchoring filaments and integrin.

Question 35

Gap junctions are composed of what protein?

Answer 35

Connexins - 6 monomeners put together

Question 36

What is the function of Gap junctions?

Answer 36

provides direct celltocell communication and cell coupling.

Question 37

How many Chains that constitute Laminin and what are their names?

Answer 37

3 chains, Alpha, beta, gemma

Question 38

Where is Laminin Located?

Answer 38

the Basal Lamina

Question 39

Fibronectin is produced by...

Answer 39

Fibroblasts