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Flashcards in L5 - Pain Deck (25):
1

What is phantom pain?

When amputees still feel pain in amputated limb

2

What is analgesia?

Incapability of feeling pain

3

What did Heinbecker do?

Took a heat stimulus to a hand
Recorded neurons in wrist
When heat actually got painful, nociceptor started firing a lot

4

What do A-d respond to?

Sharp pain
Mechanoreceptor

5

What to c fibres respond to?

Heat, pressure, noxious chemicals (ache feeling)

6

What is Na channel 1.7?

Has cell bodies in DRG
TTX blocks channel and get no current
Important in burning pain

7

What is erythromelalgia?

Experience a burning pain in their warm feet caused by a mutation

8

What mutation is in Na channel 1.7 to cause erythromelalgia?

F1449V
Opens channels so lots of pain stimuli

9

What mutation can give no pain?

W897X in Na 1.7

10

What does aspirin do?

Blocks cyclooxygenase making the prostaglandin in inflammatory soup
- Modifies Ser-530

11

What are NSAIDS and what are the two examples/

non steroidal anti inflammatory drugs
Ibuprofen
Paracetamol

12

What does ibuprofen do?

Inhibitor of cylooxygenase

13

What does paracetamol do?

COX-3 inhibitor

14

What does capsaicin do?

Activaties TRPV1 channels

15

What do capsaicin patches do?

Blocks creation of action potential

16

What happens in the substantia gelatinosa?

Sensory neurons come in through top and make connections and go down to dorsal horn
anatomically arranged

17

What are enkephalins sometimes called?

endogenous opioids

18

What does morphine do?

Analgesic in spinal cord

19

What are the features of Substance P?

11 aa peptide
Found in CNS and dorsal horn
example of a tachykinin

20

What does capsaicin block?

C fibres

21

What is TENS?

Stimulates large fibres dealing with pain

22

What are another category of pain modulators?

SSRIs and SNRIs as analgesics
Seretonin and adrenaline stay around

23

What part of the brain has nocioceptors?

meninges only

24

What part of the brain is to do with emotions and pain?

Anterior cingulate cortex (ACC)

25

What does the ACC require?

LTP