L5: Tubular Function 2 Flashcards
The kidney is not a plasma membrane instead it is a membrane across ____ cells
epithelial
What are diuretics?
A diverse group of chemical compunds that promote Na excretion. When we lose sodium we pull water with it
Why are diuretics used in clinical medicine?
To treat ECF accumulation (edema)
How are diuretics classified?
According to site of action in tubule
PCT diuretics
I osmotic diuretics
carbonic anhydrase inhibitors
TAL diuretics
II loop diuretics
DCT diuretics
III thiazide diuretics
CD-principal cell diuretics
IV potassium sparing diuretics
Diuretic ___ urinary flow rate
increases
What is the purpose of diuretics
increase water excretion (alters NaR)
What is an antidiuretic?
reduces water excretion
Filtered load =
Filtered load = GFR x [P]s
Transcellular and paracellular
through , b/w
NHE3
important for Na and H exchange
SGLT2
sodium and glucose transport - 1:1 ratio
What is NHE3 regulated by? 2
SNS
ANg II
AngII is a vaso____ and also the #1 regulator of
const, NaR
SGLT2 is found on the __ membrane and GLUT2 is on the ____ membrane (90%)
apical, basolateral
The capacity of ___ is exceeded in DM and is related to ___
SGLT2, gluosuria (eating more sugars than the body can process)
Mutations in __ can cause glucosuria
GLUT2
Defect in PCT can lead to . Ex of defect
proteinuria - megalin receptor
There are numerous aa transporters on the ___ and ____
apical, basolateral
Proteins and peptides are ____ and released as ___
endocytosed, aa’s
NaR - Late PCT
Paracellular
mostly ___
diffusion
