L6: Organic Psychiatry Flashcards
(100 cards)
What are 3 causes of organic mental disorders?
- Coarse brain disease
- Identifiable general medical conditions
- Intoxication and withdrawal from substances
What is dementia?
Syndrome characterised by an appreciable deterioration of cognition in an alert person
It results in impaired performance of daily activities
How common is dementia?
5% of persons
> 65 years have moderate or severe dementia 20% of persons
> 80 years have moderate or severe dementia
Prevalence doubles approximately every 5 years after the age of 60 years
What are 5 reasons why to investigate cognitive decline?
- 10-20% of patients with dementia have a potentially reversible condition e.g. hypothyroidism
- Intercurrent medical problems are common
- Benchmark for future comparison (CT head)
- Baseline normal values prior to treatment (haematology & biochemistry)
- * No correlation between cerebral atrophy on CT and cognitive function
What are 5 characteristics of hypothyroidism?
- Weight gain
- Bradycardia
- Ankle jerks
- Dry skin
- Cognitive decline
What are 4 causes of dementia?
- Alzheimer’s Disease 60 % of cases
- Cerebrovascular Disease 5-20% of cases
- Mixed AD & CVD
- Other e.g. Parkinson’s disease, brain tumor, HIV, head injury, hypothyroidism, neurosyphilis, hydrocephalus
What are 5 risk factors for AD?
- Old Age
- Family
- History of AD
- Down’s Syndrome
- Apolipoprotein E - allele 4
- Less education?
Alzheimer’s Disease focuses on _____, ______ and _____ lobes
frontal; temporal; parietal
What are 3 characteristics of the clinical picture of dementia?
- Gradual deterioration
- Usually obvious in physios and other members of society compared to family members
- Disease is subtle
- Occurs over a few months to a few years
- Gradual decline after one or more clinical events is common e.g. pneumonia, fractured hip
What are 3 changes in dementia?
- Cognition
- Level of functioning
- Personality and behaviour
What are 7 characteristics of decreased cognition in dementia?
- Loss of recent memory - progresses to involve more remote memories
- Overlearned tasks are preserved
- Language - difficulty with word-finding
- Calculation, handling money
- Comprehension of written material
- Recognition of people
- The capacity to reason, learn new information and solve problems is gradually lost
What are 3 characteristics of the level of functioning in dementia?
- Impaired ability to perform personal care tasks
- Reduced capacity to perform activities of daily living
- Reduced capacity to engage in social activities
What are 6 characteristics of personality and behaviour in dementia/
- Indifference or regression (filters out nasty comments)
- Unable to change behaviours
- Lack of insight Impaired planning and judgment
- Agitation, aggression, restlessness, wandering
- Hallucinations, delusions
- False unshaken belief
- Eg. wife is having an affair (completely refractory) Disturbances of sleep
What are 12 characteristics of vascular dementia?
- Abrupt onset
- Stepwise deterioration
- Fluctuating course
- Nocturnal confusion
- Relative preservation of personality
- Depression and emotionality
- Somatic complaints
- History of hypertension
- History of strokes
- Evidence of associated atherosclerosis
- Focal CNS symptoms
- Focal CNS signs
What are 6 risk factors for vascular dementia?
- Old Age
- Family History of Dementia or Stroke
- High Blood Pressure
- Low levels of High Density Lipoprotein Cholesterol (HDLC)
- Tobacco Smoking
- Alcohol Abuse
What are 5 dementia-related behaviour problems?
- Wandering
- Agitation
- Inappropriate sexual behaviour
- Delusions occur in 30-57% of patients with AD
- Hallucinations in 10-28% of patients
What are 5 causes of behaviour problems in dementia?
- 50% of dementia patients have at least one co-existing medical illness
- Sensory impairment
- Medication
- Psychiatric illness
- Environmental and social factors
Consider behaviour as communication
How does medication act as a behaviour problem?
- Takes longer to excrete medication in an older person
- Half life = amount of time taken to excrete half of drug
- Half life in an adult = 24 hrs
- Half life in an 80 year old = 80 hrs Eg. taking valium
What are 4 characteristics of “Acute Confusional State” in delirium?
- Usually transient (In end of life = can be permanent) disturbance of attention and cognition
- Abnormal psychomotor behaviour
- Altered sleep-wake cycle
- 16-35% of elderly inpatients have delirium on admission to hospital or develop delirium within three days
What are 7 clinical features of delirium?
- Clouding of consciousness
- Impairment of attention and memory
- Psychomotor agitation (1/3 of patients) or retardation ( 2/3 of patients)
- Abnormal affect or mood
- Hallucinations, delusions (Sometimes can be very lucid)
- Disorganised thinking
- “Sundown” effect
What are 6 reasons of why delirium has clinical significance?
- Common condition, but often misdiagnosed
- High mortality (~ 20%)
- Presenting clinical syndrome of serious physical illness
- May lead to self-harm or dangerous behaviour
- Recalled as a distressing experience by at least half of patients
- May be mistaken for other conditions
Delirium shows that the body is extremely ____. Everyone can have delirium but with a ____ (larger/smaller) brain in older people, there is ____(more/less) reserve. If a young person has delirium, they are very ____.
sick; smaller; less; sick
What are 8 causes of delirium?
- Brain disease or systemic disease affecting the brain
- Intoxication or withdrawal (esp. alcohol)
- Dehydration
- Drugs - prescribed or illicit (including withdrawal) Infection
- Electrolyte imbalance Na = 112g –> clouding of consciousness
- Malignancy (disease process and treatment)
- Endocrine
- Cerebral reserve
What are 7 features of management in delirium?
- Recognition and treatment of the cause
- Maintenance of intake, electrolyte balance etc.
- Ensure safety of patient and staff
- Consistent, low-stimulus environment with familiar staff, objects
- Night lighting
- Low-dose haloperidol or risperidone
- Alcohol Withdrawal Scale to titrate diazepam if alcohol withdrawal (plus thiamine)




