L6- Receptor Pharmacology

Question 1

Agonist

Answer 1

Have affinity and efficacy

Question 2

Antagonist

Answer 2

Affinity no efficacy

Question 3

Can receptor activation have an inhibitory response

Answer 3

Yes

Question 4

Full agonist

Answer 4

100% response

Question 5

Partial agonist

Answer 5

50% response

Question 6

Neutral antagonist

Answer 6

0% response

Question 7

Inverse agonist

Answer 7

-50% response

Question 8

Chemical antagonism

Answer 8

One drug antagonises the action of another by chemically combining with it

Question 9

Pharmacological antagonism

Answer 9

When drugs counteract each other by acting on the same receptor type

Question 10

Physiological antagonism

Answer 10

When 2 drugs counteract each other by producing opposing effects on different receptors

Question 11

Effect of Increased agonist conc on response in regards to competitive antagonism

Answer 11

Restore response

Question 12

Cause of irreversible competitive antagonism

Answer 12

Covalent bonding

Question 13

Can agonists and antagonist have the same effect

Answer 13

Yes - depending on receptor location

Question 14

What does physiological response depend on

Answer 14

Ion permeability- GABA causes hyper polarisation (cl- ion)

Question 15

G protein coupled receptors

Answer 15

A signalling pathway which is activated depending on G protein coupling. Has 7 transmembrane domains

Question 16

Importance of GPCRs and examples of drugs

Answer 16

Involved in numerous physiological responses and a target for over half of all prescribed medicines. Eg hyoscine- Mach receptor antagonist
Promethasine-H1 receptor antagonist