L9 - Acid Base Balance Pt3 - The Renal System Flashcards
1
Q
What do renal mechanisms allow for?
A
Long term regulation allows direct secretion od acids or alkali’s.
2
Q
What are the 3 renal mechanisms?
A
HCO-3 handling/reabsorption
Urine acidification
Amonia synthesis
3
Q
Proximal Cell Model - Apical Membrane
A
Na/H exchanger - Na+ in H+ out
CO2 & H2O move in to create H2CO3 (carbonic acid)
4
Q
Proximal Cell Model - Basolateral membrane
A
Na/K Pump
HCO-3/Na+ co-transporter
5
Q
What is base conservation?
A
The conservation and retention of bicarbonate to act as a buffer
6
Q
How is ammonia made?
A
By the breakdown of glutamine to alpha-ketoglutarate in the cells
7
Q
What are the products of glutamine breakdown?
A
hydrogen ions, ammonia and alpha-ketoglutarate
