Lab 3 & 4 Flashcards
Cushing’s disease
Hyperadrenocorticism
syn. 1. Hypercortisolemia
2. cushing’s syndrome
Clinical signs of Hyperadrenocorticism
Polyuria; polydipsia
polyphagia
panting
abdominal distention
hepatomegaly
muscle weakness
pot bellied appearance
dermatologic signs of Hyperadrenocorticism
Symmetric truncal alopecia
Hyperpigmentation
Comedones
Thin skin
poor hair regrowth
Diagnostic process for Hyperadrenocorticism
- Urinalysis
2, Chemistry Panel - CBC
- Lddst
- ACTH stimulation test
- Urine-cortisol-to-creatinine ratio
Urinalysis (Hyperadrenocorticism)
specific gravity < 1.008
Protenuria may be noted and quantified with urine protein-to-creatinine ratio
Chemistry Panel (Hyperadrenocorticism)
increased alkaline phosphatase (ALP) activity
CBC (Hyperadrenocorticism)
stress leukogram (neutrophilia, lymphopenia, monocytosis and eosinopenia)
Forms of Hypoadrenocorticism
- Primary Hypoadrenocorticism
- Atypical Hypoadrenocorticism
- Secondary Hypoadrenocorticism
Adrenal destruction is purported to spare the glomerulosa layer, resulting in an isolated glucocorticoid deficiency.
Atypical Hypoadrenocortcicism
results from immune-mediated destruction of adrenal cortical tissue. the adrenal glands don’t make enough of the hormones cortisol and aldosterone
Primary Hypoadrenocorticism
refers to a central (anterior pituitary) deficiency of ACTH, resulting in isolated glucocorticoid inusfficiency
Secondary Hypoadrenocorticism
Primary hypoadrenocorticism is reported in what ages in dogs
young to middle-aged female dogs
Atypical Hypoadrenocorticism is primary seen in what group
Occurs at older ages
Clinical signs of mineralocorticoid insufficiency
-Low sodium concentrations
-high potassium concentrations
Glucocorticoid insufficiency
Lethargy/weakness
Shaking
Polyuria / Polydipsia
Vomiting / diarrhea
Abdominal pain
Inappetence/ weight loss
Gold standard for diagnosis or all forms of hypoadrenocorticism
ACTH stimulation test
Treatment for hypoadrenocorticism
Aggressive IV isotonic crystalloids
- Monitoring of packed cell volume / total solids, serum electrolytes, and blood glucose on every 6-8 hours until values have normalized and patients is clinically stable
What to avoid in emergency setting for Hypoadrenocorticism
- avoid administration of prednisone, prednisolone and cortisone acetate
- avoid SC admin of DOCP
- avoid PO admin of any medication
