Labor & Analgesia Pt. 2 (Exam III) Flashcards

(67 cards)

1
Q

Name the anatomy pertinent to an epidural/spinal.

A
  1. Skin
  2. Subcutaneous tissue
  3. Supraspinous ligament
  4. Interspinous ligament
  5. Ligamentum flavum
  6. Epidural space
  7. Dura mater
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2
Q

What three interspinous spaces are typical for epidural placement?

A

L2-3
L3-4
L4-5

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3
Q

What are the disadvantages of a continuous epidural? 5

A
  • 10 - 15 min onset of analgesia (slow)
  • Higher drug requirement
  • ↑ Maternal LAST risk
  • ↑ fetal drug exposure
  • Risk of sacral “sparing” slow blockade.
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4
Q

What is the standard “test dose” used for epidurals?

A

Lidocaine 1.5% w/ 1:200k epi (3mls)

Change in HR indicates intravascular epinephrine.

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5
Q

What would intrathecal placement of an epidural present like when injecting your test dose?

A

Leg numbness & warmth (Lidocaine 1.5% going intrathecal). Heavy and high spinal risk.

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6
Q

Can a test dose be administered during a contraction?

A

No because then the change in HR can’t be solely attributed to the test dose.

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7
Q

What are the disadvantages of a CSE (combined spinal epidural) ? 4

A
  • ↑ risk of fetal bradycardia
  • ↑ risk of PDPH
  • ↑ risk of neuraxial infection
  • Uncertainty of proper epidural catheter placement (until spinal wears off).
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8
Q

Why can fetal bradycardia sometimes occur with CSE ?

A
  • Due to sympathetic blockade & maternal HoTN.
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9
Q

What is a Dural Puncture Epidural?

A

Similar to CSE but no medications are injected into the spinal space.

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10
Q

What are the advantages of a Dural Puncture Epidural? 4

A
  • Faster onset than regular epidural
  • Transdural migration of medications injected into epidural space
  • More rapid anaglesia
  • ↓ risk of maternal HoTN and fetal bradycardia compared to CSE.
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11
Q

When is a continuous spinal utilized?

A

After a “Wet Tap”.

Accidental placement of epidural Tuohy into the spinal space.

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12
Q

What are the disadvantages of a continous spinal? 2

A
  • Large dural puncture = PDPH
  • Risk of other provider mistaking catheter for an epidural catheter instead of a spinal.
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13
Q

What types of pain do epidural local anesthetics treat?

examples of each.

A
  • Visceral Pain: lower uterine & cervical distention
  • Somatic Pain: Fetal birth canal descent
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14
Q

Which two LA’s are most commonly used for labor?

A

Bupivacaine & Ropivacaine

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15
Q

What is a differential block? What neurons are spared?

A
  • Separation of motor & sensory effects
  • Sparing of A-α motor neurons
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16
Q

What are the advantages of Bupivacaine? 4 (Hint: Compared to Lidocaine/Chlorprocaine)

A
  • Differential Block
  • Long duration
  • No tachyphylaxis
  • Safety (↓ placental transfer)
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17
Q

What are the disadvantages of neuraxial bupivacaine? 2

A
  • Slow onset time (10 - 15 min)
  • Risk of CV & neuro toxicity
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18
Q

How can the latency time of bupivacaine/ropivacaine be improved?

A

Addition of a lipophillic opioid.

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19
Q

What are the advantages of Ropivacaine? (To bupivacaine) 2

A
  • Differential Block (even better than bupivacaine).
  • Safety (less toxic than bupivacaine)
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20
Q

What are the disadvantages of ropivacaine? 2

A
  • Slow onset (10 - 15 minutes)
  • CV & Neuro toxicity
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21
Q

Why is lidocaine not routinely used for labor analgesia? 3

A
  • Poor differential block
  • Tachyphylaxis risk
  • ↑ placental transfer / ion trapping
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22
Q

What is neuraxial lidocaine useful for? 2(3)

A
  • Identification of non-functional catheter
  • Need for rapid sacral analgesia
  • Instrumented vaginal delivery/perineal repair
  • Emergent operative delivery
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23
Q

What dose of neuraxial lidocaine is used for emergent operative delivery?

A

2% Lidocaine 10 - 20 mls w/ 2mls of Na⁺Bicarb

Bicarb (2mls) w/ 18mls of 2% Lido

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24
Q

What will bicarbonate do when paired with lidocaine in neuraxial anesthesia?

A

Speed up onset

Good for emergent operative delivery.

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25
What dose of lidocaine is used for identification of a non-functional catheter?
5 - 10mls of 2% Lidocaine
26
What are the advantages and disadvantages of Chloroprocaine? 1:2
Advantages: -Rapid onset Disadvantages: - Short duration - Poor differential blockade
27
What are the disadvantages of chloroprocaine? With adjuncts?
- Short duration of action - Interferes with bupivacaine/opioids
28
When is neuraxial chloroprocaine useful?
Emergent instrumented or operative delivery and/or perineal repair
29
What are the benefits of neuraxial opioids? 4
- ↓ LA dosage (20 - 30% reduction) - ↓ latency - ↑ analgesia - ↑ duration of analgesia
30
Which opioids will have a faster onset? Examples (2)
Lipophillic (fentanil, sufentanil, etc)
31
Which neuraxial opioids will have a later onset (but provide postoperative pain relief) ?
Hydrophillic *Morphine*.
32
What is the dose of neuraxial clonidine?
75 - 100 mcg
33
What are the advantages of neuraxial clonidine? 4
- Analgesic - ↓ LA requirement - ↑ block quality/duration - No motor blockade
34
What are the disadvantages of neuraxial clonidine?
- Maternal HoTN & bradycardia - Maternal sedation
35
What is the typical dose of neuraxial dexmedetomidine?
0.25 - 0.5 mcg/mL
36
What is precedex used for in neuraxial anesthesia? 3
- ↓ latency - ↑ duration of block - ↓ LA requirement
37
What adverse effects can occur with higher concentration of neuraxial dexmedetomidine?
Maternal sedation & anxiolysis
38
What is the MOA of neuraxial Precedex? 2
- Suppressed C-fiber transmission - Hyperpolarization of postsynaptic dorsal horn neurons.
39
What is a PCEA? And benefits (2)?
Patient controlled epidural anesthetic - Less motor blockade - Less dosing by provider
40
What is the main factor in determination of LA dosing for a spinal?
**Patient height & level of anesthesia desired**.
41
How many mg of bupivacaine is being administered to a patient receiving 1.7mls of 0.75% bupivacaine?
1.7 x 7.5 = 12.75mg Bupivacaine
42
Can opioids be used as a solo agent for neuraxial anesthesia?
Yes Analgesia w/ no numbness, motor blockade, or sympathectomy. *More commonly used as an additive however*.
43
What is the dose of hyperbaric bupivacaine?
0.75%
44
What is the dose of isobaric bupivacaine?
0.5%
45
What is the isobaric dose of spinal ropivacaine?
0.5% *Not commonly used*.
46
What is the dose of spinal dexmedetomidine?
2.5 - 10mcg
47
What is the purpose of spinal dexmedetomidine ? 2
- Prolongs analgesia - ↓ latency
48
What is the purpose of intrathecal epinephrine? 2
- Prolonged analgesia - increased motor blockade (with higher dosing)
49
What would a higher dose of spinal epinephrine (100 - 200mcg) do?
↑ motor blockade
50
How is neuraxial hypotension typically treated?
- IV fluids - Positioning - Vasopressors (last)
51
What is the most common complaint associated with neuraxial opioids?
Pruritus
52
Why does pruritus occur with neuraxial opioid administration?
Central μ-opioid receptors
53
What dose of diphenhydramine (Benadryl) is used for neuraxial opioid pruritus?
Trick question. Itching is not due to histamine release. Benadryl will not work.
54
What drug is used to treat neuraxial opioid pruritus?
Centrally acting μ-opioid antagonist - Naloxone 40 - 80mcg IV - Naltrexone 6mg PO Partial Agonist-Antagonist - Nalbuphine 2-5mg IV - Butorphanol 1-2mg IV
55
What are the conservative treatment options for a "wet tap"?
- Caffeine - Laying down (positioning)
56
What are the more invasive treatment options for PDPH?
Epidural blood patch
57
Should CSF be reinjected after wet-tap occurs with a Tuohy needle?
**No**. ↑ risk for infection/pneumocephalus
58
Why is bupivacaine 0.75% not used for epidural blocks?
Risk for CV toxicity if injected
59
What are the mild/moderate signs/symptoms of LAST? 4
- Tinnitus - Circumoral numbness - Restlessness - Difficulty speaking
60
What is the treatment for LAST?
1.5 mL/kg Lipid emulsion bolus & benzodiazepines
61
What are the signs/symptoms of a high spinal? 4
- Agitation - Dyspnea - Inability to speak - Profound hypotension - Apnea
62
How is a high spinal treated?
- Ventilation assistance - Volume resuscitation - Vasopressors
63
Pinky/hand numbness is associated with what spinal level?
C8
64
Cardioaccelerator fibers originate from what spinal levels?
T1-T4
65
Diaphragmatic ennervation comes from which spinal levels?
C3-C5
66
Thumb numbness is associated with what spinal level?
C6
67
What are the signs/symptoms of a subdural block?
- Unexpectedly high blockade w/ patchiness - Profound HoTN - Minimal motor blockade - Horner's syndrome - Apnea - LOC changes