Labs & Tutorials

Question 1

Rhesus factor pattern of inheritance?

Answer 1

Autosomal dominant

Question 2

5 categories of antibiotics, based on their mode of action:

Answer 2

1. Inhibition of the bacterial cell wall (peptidoglycan) synthesis (penicillin , ampicillin, methicillin, cephalosporins)
2. Destruction of the cell membrane
   - Polymyxins (polymyxins B and E)
   - Polyenes (amphotericin B, nystatin)
3. Inhibition of protein synthesis by binding to prokaryotic ribosomes (streptomycin, chloramphenicol, tetracycline, erythromycin)
4. Inhibition of nucleic acid synthesis (rifampicin, metronidazole)
5. Growth supplement analogues

Question 3

Antibiotics that inhibit the bacterial cell wall (peptidoglycan) synthesis (4)

Answer 3

• transpeptidase is responsible for peptidoglycan synthesis in bacterial cell wall
• used for Gram (+) bacteria only

penicillin , ampicillin, methicillin, cephalosporins

Question 4

Polymyxins (2)

Answer 4

Antibiotics that destruct PM

• used for Gram (-) bacteria
• polymyxins B and E

Question 5

Polyenes (2)

Answer 5

Antibiotics that disrupt PM

• used for fungi
• amphotericin B, nystatin

Question 6

Antibiotics that inhibit protein synthesis by binding to prokaryotic ribosomes (4)

Answer 6

• Used only for bacteria

streptomycin, chloramphenicol, tetracycline, erythromycin

Question 7

Antibiotics that inhibit nucleic acid synthesis in mycobacteria (1)

Answer 7

rifampicin

Question 8

Antibiotics that inhibit nucleic acid synthesis in anaerobes (1)

Answer 8

metronidazole

Question 9

Antibiotics that are growth supplement (folic acid) analogues (1)

Answer 9

sulfonamides

Question 10

Antibiotics that are growth supplement (folic acid) analogues (1)

Answer 10

sulfonamides