Lassila Clopidogrel Flashcards
1
Q
How long does it take for clopidogrel to start inhibiting platelets?
A
~10 days due to platelet lifespan
2
Q
What enzyme metabolizes the prodrug clopidogrel to its active form?
A
CYP2C19
3
Q
What warning is listed on the clopidogrel drug label?
A
CYP2C19 poor metabolizers (decreased active metabolite exposure) have an decreased effectiveness and higher CV event rates than normal function
4
Q
What are potential benefits for the patient?
A
ACS and PCI support use of geno-type guided strategy
