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HLS Immunity > Lec 1 > Flashcards

Lec 1 Flashcards

1
Q

What is the steam cell that give rise blood cell?

A

Hematopoietic steam cell

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2
Q

Hematopoietic steam cell differentiate to?

A

Lymphoid steam cell & myeloid steam cell

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3
Q

Myeloid stem cell give ?

A

RBCs , all leukocytes except lymphocytes,platelet by differentiated to megakaryocyte

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4
Q

Lymphoid stem cell give ?

A

Lymphocytes (B & T & NK cells

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5
Q

What is the typical immune response ?

A

Innate & acquired immunity

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6
Q

Innate divided to ?

A

Internal & external immune response

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7
Q

What is the external immune response ?

A

Skin , mucous membranes , secretion

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8
Q

What is the internal innate immune response ?

A

Phagocytic cell , antimicrobial proteins , inflammatory response , NK cell (lymphocytes)

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9
Q

What is the acquired immunity ?

A

This immunity is due to lymphocytes and divided to :
Humoral response which cause by antibodies (B cell)
Cell mediated response which caused by cytotoxic T cell

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10
Q

Which type of leukocyte responsible in innate & acquired immunity?

A

Lymphocytes and eosinophils

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11
Q

What is the hematopoiesis?

A

Blood formation

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12
Q

What is the macrophages ?

A

Monocytes that migrate to tissues

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13
Q

What is the count of monocytes?

A

5% of WBCs

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14
Q

What is the kupffer cell?

A

Monocytes that migrate to liver OR macrophages in liver

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15
Q

What is the osteoclasts, microglia , intestinal macrophages, alveolar macrophages ?

A

It is macrophages in bone , brain ,intestine and lung respectively

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16
Q

What is the main function of monocytes?

A

Phagocytosis .Also , antigen presentation

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17
Q

What is the big eaters cell?

A

Macrophages

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18
Q

What is the most abundant WBCs?

A

Neutrophils (50-60% of WBCs)

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19
Q

What is the Polymorphonuclear cell and why it called that?

A

Neutrophils because it have segmental nucleus

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20
Q

How long lifespasm of RBCs?

A

120 day

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21
Q

How long lifespasm of neutrophils?

A

7 houres

22
Q

What is the mature neutrophils called?

A

Segmental neutrophils

23
Q

What is the process that leukocytes invade to tissue?

A

Diapedesis

24
Q

Inflammation doesn’t affect diapedesis?

A

F , it increased it

25
Q

Which cell have powerful phagocytosis?

A

Macrophages have more powerful phagocytosis than neutrophils

26
Q

Does neutrophils have lipase to digest phagocytes ?

A

Noooo , just macrophages

27
Q

What is the process which neutrophils used to kill microbes after phagocytosis?

A

Killing by oxidizing agent

28
Q

Which WBCs increased in bacterial infection ?

A

Neutrophils because it have fastest response to bacteria

29
Q

Which WBCs increased in virus infection ?

A

Lymphocytes

30
Q

Which WBCs increased in allergy?

A

Eosinophils

31
Q

What is the substance that found in basophils granules?

A

Vasoactive amines (histamine-serotonin-heparin)

32
Q

How many loops found in neutrophils?

A

2-5 loops

33
Q

How many loops found in basophils

A

2

34
Q

What is mast cell

A

Basophils that migrate to tissue

35
Q

What is the granulocytes ?

A

WBCs that contain granules (neutrophils, basophils, eosinophils)

36
Q

Which WBCs increased in parasitic infections ?

A

Eosinophils

37
Q

What is the main function of basophils?

A

Secrete vasoactive amines

38
Q

What is the main function of eosinophils

A

Released histamine & attack parasite

39
Q

Where is B cell maturation?

A

In bone marrow

40
Q

Where is T cell maturation ?

A

I’m thymus

41
Q

Developed of lymphocytes to B or T cells depend on ?

A

Site of maturation

42
Q

Where T & B cell formed and where it maturation

A

Firstly, lymphocytes formed in bone marrow and it doesn’t known that if it T cell or B cell until it maturation , if it maturation in bone marrow , B cell will form . And if it maturation in thymus , T cell will form

43
Q

T cell divided to ?

A

T helper cell which helped B cell to produce antibodies

T cytotoxic cell which kill foreign bodies

44
Q

Which cell secret antibodies?

A

B cell

45
Q

What is the function of total count of blood cell?

A

This indicate the degree of response to infection .
Differential count will provide specific diagnosis of infection , such as increase neutrophils mean bacterial infection and so on

46
Q

If one type increased , does the other type decreased ?

A

No , the proportional decreased just but the number of it will still

47
Q

What is the count of lymphocytes

A

24-40%

48
Q

What is the count of monocytes

A

5-9%

49
Q

What is the count of eosinophils

A

2-4%

50
Q

What is the count of basophils

A

0.5-1%

HLS Immunity (1 decks)

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