Lec 11-12 Vasculitis Flashcards
(32 cards)
What are clinical feat of small vessel vasculitis?
skin lesions universal
limited internal organ involvement
What are clinical feat of medium vessel vasculitis?
- skin lesions less prominent
- varied but marked internal organ involvement
What are clinical feat of large vessel vasculitis?
minimal skin disease
prominent symptoms related to ischemia/ organ infarct
What is hypersensitivity vasculitis?
serum sickness
can be drug induced by penicillin, sulfa
have low grade fever , polyarthralgias/arthritis, maculopapular purpuric rash
What do you see in hep C vasculitis? 2 signs?
dependent palpable purpura
peripheral neuropathy
membranoporliferative glomerulonephritis
serum cryoglobulins + RF
What is henoch-schonlein purpura?
self limited small vessel vasculitis in kids; follows URI
What is classic triad of henoch shonlein purpura?
- palpable purpura on buttocks/legs
- srthralgias
- GI –> ab pain, melena
What do you see when you biopsy the purpura of HSP?
IgA complex deposition = have IgA + C3 in vessel wall
What is bechet’s syndrome?
syndrome of recurrent mucosal ulcers in mouth and genitals
have uveitis, arthritis, cutaneous vasculitis
What is treatment for bechet?
colchicine
What is relapsing polychondritis?
episodic cartilaginous inflammation of both auricles; polyarthritis; saddle nose; malar rash
associates w/ SLE, IBD
WHat is treatment of small vessel vasculitis?
eradicate the antigen; NSAIDS; steroids; immunosuppression
What are three causes of infections medium vessel vasculitis?
Hep B
Hep C
HIV
What is buerger’s disease?
medium vessel vasculitis
heavy smoking –> intermittent claudication of extremity vessels
Who gets buerger disease?
male heavy smokers < 40
WHat is pathology of buergers?
PMN infiltration of vessel wall w/ thrombosis, intact elastic lamina
What is pathology of polyarteritis nodosa?
- associated with Hep B
- focal lesions at bifurcations esp renal arteries
- lungs spared
- fibrinoid necrosis
- non granulomatous
What is treatment for PAN?
corticosteroids
cyclophosphamide
What is microscopic polyangiitis?
small vessel necrotizing vasculitis involving lungs, kidney, skin, pauci-immune glomerulonephritis
What type of ANCA associated with microscopic polyangiitis?
MPO-ANCA/p-anca = anti-myeloperoxidase
What is treatment for microscopic polyangiitis?
cyclophosphamide
corticosteroids
What is triad of wegeners?
- focal necrotizing vasculitis
- necrotizing granulomas in lung and upper airway
- necrotizing glomerulonephritis
What parts of body involved in wegener’s?
- upper respiratory tract [differs from microscopic polyangiitis]
- lower respirator tract
- renal
What are symptoms of churg strauss?
asthma, sinusitis, palpable purpura, peripheral neuropathy
can also involve heart, GI, kidneys [pauci-imune glomerulonephritis]
eosinophilia
