Lec 12 - Latent and Persistent virus Flashcards
diff between latent and persistent virus
latent virus = maintained in inactive state in the cell, undetectable unless disease is reactivated
persistant virus = long term infections with constant low levels of virus production
all latent viruses are persistant viruses
what type of cells are typically infected by persistant viruses
cells of the immune system (means it can destroy it alongside also)
or
neurones
example of a cellular protein that my be blocked to prevent apoptosis
Bcl-2
what type of cells, that flag the virus to immune system, can be destroyed by persistant viruses
cytotoxic t lymphocytes (CTL)
prevents hosts t cells from detecting viral infected cells
which protein is responsible for antigen presentation (and is inhibited by persistent viruses in diff ways)
MHC class 1
and 2
which virus inhibits Bcl2
sindbis virus
therefore prevents apoptosis
diff in sindbis virus injection into adult mice vs neonates
in adult = causes non cytopathic persistant infection as expected
in neonates = death
- lack proteins that prevent apoptosis
what does CTL interact with to be activated
their TCR interacts with MHC Class I on cells
what virus good at intefering with trafficking of MHC Class I protein
human cytomegalovirus
cytomegalovirus is usally inapperent, but what could reactivate viral replication
immunosupprestion
HIV infection
how can cytomegalovirus affect pregnant women
the virus can cross placental barrier and infect the fetus
= developmental issues - vary depedning on which gestational period the mum gets infected
which 2 proteins from cytomegalovirus cause MHC Class I to be injected from ER to cytoplasm
US2
US11
they displace the heavy chain as its on the way to the membrane
which protein in HIV inhibits transcription of MHC I
tat protein
which HIV prtein internalises MHC protein into the cell frmo the membrane
Nef
what else can Nef protein internalise
CD4
