Lec 14/15

Question 1

erythropoietin is a?

Answer 1

166 amino acid glycoprotein

Question 2

define Recombinant DNA

Answer 2

modified DNA strand that is produced when a small piece of DNA is added to the genome (DNA molecule) of another organism

Question 3

t/f biotechnology encompasses any technique that uses living organisms in the production or modification of products.

Answer 3

true

Question 4

T/F oral administration can be used for most protein drugs

Answer 4

false, not for most protein drugs

Question 5

define basal insulin

Answer 5

insulin normally supplied to pancreas with or w/o food

Question 6

define bolus insulin

Answer 6

insulin produced in response to glucose

Question 7

basal insulins are intermediate/long acting or rapid/short acting?

Answer 7

intermediate/long acting

Question 8

bolus insulins are intermediate/long acting or rapid/short acting?

Answer 8

rapid/short acting

Question 9

lispro, aspart, and glulisine are which type of insulin?

Answer 9

rapid-acting

Question 10

regular humulin or novolin are which type of insulin?

Answer 10

short-acting

Question 11

isophane is which type of insulin?

Answer 11

intermediate-acting

Question 12

glargine and detemir are which type of insulin?

Answer 12

long-acting

Question 13

short-acting (Humulin R) insulin may be stored at room temperature for how many days?
can it be frozen?

Answer 13

28 days

no

Question 14

t/f rapid-acting insulin should be given right before or right after a meal

Answer 14

true

Question 15

what is Lipohypertrophy?

Answer 15

a lump under skin caused by accumulation of extra fat that typically occurs due to SC injections of insulin

Question 16

growth hormone deficiency occurs due to?

Answer 16

pituitary gland not producing enough growth hormone

Question 17

what is the name of the drug used as growth hormone replacement therapy?

Answer 17

somatropin

Question 18

Lepirudin (refludan) is what drug class?

Answer 18

anticoagulant drugs

Question 19

tissue plasminogen activator is a protein involved in the breakdown of?
what is it used for?

Answer 19

blood clots

acute myocardial infarction, stroke, and pulmonary embolism

Question 20

alteplase (activase) is what drug class?

Answer 20

tissue plasminogen activator

Question 21

what is hemophilia?

Answer 21

a bleeding disorder

Question 22

antihemophilic factor (kogenate, recombinate) is what drug class?

Answer 22

clotting factor

Question 23

Colony Stimulating Factors (CSF) are glycoproteins that stimulate stem cells in
bone marrow to form a specific kind of white blood cell called?

Answer 23

neutrophil

Question 24

filgrastim (neupogen, imumax, grafeel) is what drug class?

what is it used for?

Answer 24

Colony-Stimulating Factor

cancer treatment

Question 25

Erythropoietin (EPO) is a glycoprotein hormone that stimulates the production of _________ by stem cells in bone marrow EPO is mainly produced by?

Answer 25

red blood cells | the kidneys

Question 26

``` epoetin alfa (epogen, procrit) is what drug class? what is it used for? ```

Answer 26

Erythropoietin | anemia

Question 27

Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by?

Answer 27

identical immune cells that are clones of a unique parent cell

Question 28

what is hybridoma technology?

Answer 28

produces identical antibodies in almost unlimited quantities

Question 29

rituximab (rituxan) drug class? | use?

Answer 29

MAb | treat cancers of WBCs such as leukemias and lymphomas

Question 30

Trastuzumab (Herceptin) drug class? | use?

Answer 30

MAb | block growth of tumors by binding to HER2 receptors

Question 31

Bevacizumab (Avastin) drug class? | use?

Answer 31

MAb | stop new blood vessels from forming to treat certain cancers

Question 32

``` Ibritumomab Tiuxetan (Zevalin) drug class? use? ```

Answer 32

MAb | delivers radiation drug to cancer cells to treat B cell non-Hodgkin's lymphoma

Question 33

Ado-trastuzumab Emtansine (Kadcyla) drug class? | use?

Answer 33

deliver chemo drug to cancer cells to target HER2 protein to treat breast cancer

Question 34

``` Satumomab Pendetide (OncoScint) drug class? use? ```

Answer 34

MAb | used to diagnose cancer

Question 35

Muromonab-CD 3 (Orthoclone OKT3) drug class? | use?

Answer 35

MAb | prevent organ rejection

Question 36

Adalimumab (Humira) drug class? use? what cytokine does it block?

Answer 36

MAb treat rheumatoid arthritis TNF

Question 37

what is measured in the urine by pregnancy tests?

Answer 37

hCG

Question 38

``` Fomivirsen Sodium (Vitravene) drug class? use? ```

Answer 38

MAb | treats retinitis by blocking translation of CMV gene