Lec 2 Flashcards
(22 cards)
What is the cause of B12 deficiency?
Low intake , damaged to parietal cell which produced IF , fall receptor to get B12 after bind to IF
What is the haptocorrin?
Protein which bind to B12 in stomach to prevent acidity from destroy it
Where haptocorrin separated from B12 and by what ?
In duadenum by protease enzyme which secreted from pancreas
Where IF bind to B12 ?
In duadenum after destroyed haptocorrin
Where IF and B12 separated from other ?
Terminal ilium which B12 bind to receptor in it (the site of absorption B12)
What is the rout of administration of B12 supplement?
Orraly if there dietary deficiency and IM or sC of there pernicious anemia because there is deficiency in IF so destruction B12 in stomach
What is mean by folic acid mask B12 .deficiency?
If we have B12 deficiency there are some neurological effect , so if we give folic acid we treated megaloblastic anemia but neurological effect not treatment
Which cyanocoblamine or hydroxocoblamine is more effected ?
Hydroxycoblamine because it have rapid ones of action and long duration of action due to bind to protein in blood
Erythropoietin produced in ? And what is the function of it ?
Kidney , regulated RBCs proliferation
Where we use erythropoietin?
Anemia caused by RF
Anemia caused by viral infection ( virus effected kidney)
Anemia caused by metastasis cancer to kidney
What is darbepoetin?
Long acting version of erythropoietin
What is the characteristic of darbepoetin on erythropoietin?
Decreased clearance & long half life (3 time more)
What is the rout of administration of darbepoetin?
IV in renal hemodialysis or SC
What is the side effect of erythropoietin?
Vasoconstriction mainly in arterioles so there are increase in peripheral resistance which lead to hypertension
And may increased blood viscosity which lead to thrombosis
This two event increased if HB elevated more than 12 by erythropoietin administration so we must stopped it if we rich 12
What is the value of HB elevated in 2 week treatment of Erythropoietin?
Less than 1 gram per dL in 2 week
Painful crisis come with any type of anemia and what is the cause?
With sickle cell anemia , this due to sickle cell obstruction blood vessel
What is the treatment of painful crisis?
Hydroxyurea
What is the effect of hydroxyurea ?
Increased in HbF and decreased in HbS
Also it depression bone marrow
What is the disease that hydroxyurea used in it ?
1-sickle cell anemia because it decreased of HbS
Myelogenous leukemia by depression of bone marrow (myelosupressive effect)
Polycythemia Vera (because it suppression bone marrow also)
What is the side effect of hydroxyurea?
Myelosuppression and vasculitis
In any cases we use pentoxifylline?
Sickle cell anemia with vasoocclusive crisis (vasoconstriction in peripheral blood vessel)
What is the effect of pentoiphelline?
Increased cAMP which lead to vasodilation and relax of smooth muscle which lead to decreased peripheral resistance also increased cAMP lead to prevent platelets agergation which lead to decrease viscosity
