Lec 2 Final Flashcards
(42 cards)
Immune system may attack the same MO differently according to ?
Location
Intracellularity does not apply to MO still within immune cell phagosomes ( T or F )
True
What are the phagocytes that play an important role against extracellular microbes?
1-neutrophils
2- monocytes - macrophages
Name 3 receptors that found on the surface of the phagocytes
1- Pattern recognition receptors
2- Complement receptors CR1/CR3
3- Ig receptors FcγRI and FcγRIIa
Phagocytosis and intracellular killing is important in facing:
1- Bacteria
2- Fungi (Candida spp)
3- Protozoa (Plasmodium spp, Toxoplasma spp.)
The formation of the MAC is important for killing bacteria with thin cell walls, such as Listeria monocytogenes ( T or F )
False, the answer is Neisseria
Who is responsible in opsonizing polysaccharide-rich encapsulated bacteria ?
T-independent antigens
Name the antibodies that provide protection through steric hindrance
IgG, IgM, or IgA
Secretion of IL-1, IL-6 andIL-23 will stimulate ?
ILC3s and TH17 cells
Secretion of IL-12 will stimulate ?
LC1s and TH1 cells
What triggers the development of TH1 cells?
IL-12
What are the main products produced by TH1 cells?
IFNγ and express CD40L
What is the role of TH1 cells in macrophage function?
TH1 cells are potent activators of macrophage function, particularly for macrophages that are resistant to intracellular killing. This includes pathogens such as Mycobacterium tuberculosis, Mycobacterium leprae, and Histoplasma spp.
What can be the consequence of TH1 cell activation?
Activation of TH1 cells can lead to granulomatous inflammation
What is the association between TH1 cells and Leishmania infection?
Elimination and recovery from Leishmania infection.
What cytokines do TH2 cells secrete?
IL-4 and IL-5
What is the effect of IL-4 and IL-5 secretion by TH2 cells?
inhibits macrophage function.
What is the role of TH2 cells in antibody isotype switching?
involved in isotype switching of IgE and IgG4.
What cytokines trigger the development of TH17 cells?
IL-1, IL-6, and IL-23
What is the main cytokine secreted by TH17 cells?
IL-17
What is the role of TH17 cells in immune response?
Recruiting neutrophils - maintenance of tight junctions
What types of pathogens are TH17 cells important in fighting off?
Candida spp ( a type of fungus )
Name the intracellular microbes
1- Listeria monocytogenes
2- Cryptococcus neoformans
3- Plasmodium spp
4- Toxoplasma spp
Adaptive arm attacks the infected cells which express class I HLA molecules ( T or F )
True
