lec 3 h.influenza Flashcards
(25 cards)
which type of bacteria is hemophilus influenza?
Gram negative coccobacili capnophillic
can be either encapsulated or non capsualated
H.Influenza is cultured under:
-Enriched chocolate agar = hematin and NAD
-bloood agar in prescence of staph aureus
Epidemiology of H.influenza:
nasopharyngeal, meningitis most common from in children
H.influenza type B and what it infects:
most virulent encapsulated type
can infect CNS,epiglottis and soft tissues
-Disease begins with fever and lethargy.
H.influenza type B pathogenisis:
-Normal flora invades deeper tissues
-attachment by pilli
-capsule role is to defect C3b deposition
-Endotoxin- septecemia
-Has no exotoxin.
True about the immunity of H.Influenza:
-PRP antibodies
-peak is between 6-18 months
-similar to meningococci
Clinical manifestations of H.influenza
Meningitis
acute epiglottis
cellulitis and arthritis
otitis media
pneumonia
acute and chronic bronchitis
Diagnosis of h.influenza:
clinical findings
gram stain
serotyping
treatment of h.influenza:
DOC: ampicillin or amoxicillin
if resistant, 3rd gen of cepahlosporin
Bordetella pertussis type:
slow growing Gram negative small coccobacilli
require NAD and charcoal
Attachment proteins of B.pertussis:
-(filamentous hemoagglutinin) FHA
-pilli
-pertacin in outer membrane
Extracellular products of B.pertussis:
ADP ribolysation
Adenalate cyclase toxin, cAMP increase
interferes with cellular signalling
Whooping cough of B.pertussis
Transmission: airborne
Fatal in infants <1 year
pathogenisis of whooping cough:
‘-humans affected only
-cilliated columnar epithelium, attached by pilli, FHA,OMP
-cillia damage by tracheal cytotoxin
-adenylate cyclase and PMN’s
Gene regulation of whooping cough:
-Incubation period, 7-10 days
-catrrhal, paroxysmal, convalescent
-lymphocytosis
Diagnosis of whooping cough:
-nasopharyngeal swabbing, NOT THROAT
-charcoal blood agar with cephalosporin
-drops of mercury colonies
-DFA, agglutination
treatment and prevention of Whooping cough:
supportive in late stages
clarithromycin or erythromycin in early
DTP and DTaP
Corynebacteria diptheriae :
type, respire, transmission, Incubation period
-small pleomorphic catalse-positive rods
-facultative anaerobes
-droplet spread
IP- 2-4 days
what kind of toxin does Coryne.dip have?
AB toxin (diptheria toxin): inhibits protein synthesis
Clinical manifestation of Coryne.dip
pharyngitis
resp obstruction
bulls neck
acute myocarditis
ulcers and postules
Diagnosis of C.d
clinically
potassium tulerite medium (tinsdale)
Treatment of C.d
Toxin neutralization
Beta lactams
erythromycin
vaccination with inactivated toxin
pharyngitis or tonsillitis caused by:
Adenoviruses
Peritonsillar abscess caused by;
Group A streptococci
